Effect on breathing of ventral medullary surface cooling in neonatal goats
T. F. Lowry, H. V. Forster, L. G. Pan, P. J. Ohtake, I. Epshteyn, M. J. Korducki and R. A. Franciosi Department of Physiology, Medical College of Wisconsin, Milwaukee, USA. The present study was designed to determine whether neurons near the ventral medullary surface (VMS) that are important to cont...
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| creator | Lowry, T. F Forster, H. V Pan, L. G Ohtake, P. J Epshteyn, I Korducki, M. J Franciosi, R. A |
| description | T. F. Lowry, H. V. Forster, L. G. Pan, P. J. Ohtake, I. Epshteyn, M. J. Korducki and R. A. Franciosi
Department of Physiology, Medical College of Wisconsin, Milwaukee, USA.
The present study was designed to determine whether neurons near the
ventral medullary surface (VMS) that are important to control of breathing
in adult mammals are also important to control of breathing in neonates. In
7-day-old goats (n = 22), the VMS was surgically exposed under halothane
anesthesia. Stainless steel thermodes (2 x 2 mm) were used to cool (20
degrees C) and thereby create neuronal dysfunction of discrete VMS sites.
Bilateral cooling under anesthesia 0-2 or 2-4 mm lateral to the midline
between the exit of cranial nerves VI and XII resulted in a reduction (P
< 0.05) of breathing and most often in apnea. Cooling caudal or rostral
to this area did not have a consistent effect on breathing. In 7-day-old
goats (n = 8), 3 x 3-mm thermodes were chronically implanted bilaterally on
the VMS surface between the exit of cranial nerves VI and XII. The goats
recovered and were studied over several days thereafter. VMS cooling while
the goats were awake caused breathing to decrease (P < 0.05), but apnea
was never observed. The decrease was less (P < 0.05) than while the
goats were anesthetized. After 10 s of cooling, the hypopnea while the
goats were awake was uniform during eupnea, hypercapnia, hyperoxia, and
hypoxia, but after 10 s of cooling, the decrease was relatively greater (P
< 0.05) during hyperoxia and hypercapnia. These effects of VMS cooling
are qualitatively the same as in adult goats; thus the data are consistent
with mature VMS contribution to the control of breathing in neonatal goats. |
| doi_str_mv | 10.1152/jappl.1996.80.6.1949 |
| format | Article |
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Department of Physiology, Medical College of Wisconsin, Milwaukee, USA.
The present study was designed to determine whether neurons near the
ventral medullary surface (VMS) that are important to control of breathing
in adult mammals are also important to control of breathing in neonates. In
7-day-old goats (n = 22), the VMS was surgically exposed under halothane
anesthesia. Stainless steel thermodes (2 x 2 mm) were used to cool (20
degrees C) and thereby create neuronal dysfunction of discrete VMS sites.
Bilateral cooling under anesthesia 0-2 or 2-4 mm lateral to the midline
between the exit of cranial nerves VI and XII resulted in a reduction (P
< 0.05) of breathing and most often in apnea. Cooling caudal or rostral
to this area did not have a consistent effect on breathing. In 7-day-old
goats (n = 8), 3 x 3-mm thermodes were chronically implanted bilaterally on
the VMS surface between the exit of cranial nerves VI and XII. The goats
recovered and were studied over several days thereafter. VMS cooling while
the goats were awake caused breathing to decrease (P < 0.05), but apnea
was never observed. The decrease was less (P < 0.05) than while the
goats were anesthetized. After 10 s of cooling, the hypopnea while the
goats were awake was uniform during eupnea, hypercapnia, hyperoxia, and
hypoxia, but after 10 s of cooling, the decrease was relatively greater (P
< 0.05) during hyperoxia and hypercapnia. These effects of VMS cooling
are qualitatively the same as in adult goats; thus the data are consistent
with mature VMS contribution to the control of breathing in neonatal goats.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1996.80.6.1949</identifier><identifier>PMID: 8806899</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Animals ; Animals, Newborn - physiology ; Biological and medical sciences ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Female ; Fundamental and applied biological sciences. Psychology ; Male ; Medulla Oblongata - physiology ; Respiration - physiology ; Sheep ; Temperature ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 1996-06, Vol.80 (6), p.1949-1957</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-554ba84ffffecb7e401d06a706c734a3d1a543de502d6135475306569ba08c383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3165743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8806899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lowry, T. F</creatorcontrib><creatorcontrib>Forster, H. V</creatorcontrib><creatorcontrib>Pan, L. G</creatorcontrib><creatorcontrib>Ohtake, P. J</creatorcontrib><creatorcontrib>Epshteyn, I</creatorcontrib><creatorcontrib>Korducki, M. J</creatorcontrib><creatorcontrib>Franciosi, R. A</creatorcontrib><title>Effect on breathing of ventral medullary surface cooling in neonatal goats</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>T. F. Lowry, H. V. Forster, L. G. Pan, P. J. Ohtake, I. Epshteyn, M. J. Korducki and R. A. Franciosi
Department of Physiology, Medical College of Wisconsin, Milwaukee, USA.
The present study was designed to determine whether neurons near the
ventral medullary surface (VMS) that are important to control of breathing
in adult mammals are also important to control of breathing in neonates. In
7-day-old goats (n = 22), the VMS was surgically exposed under halothane
anesthesia. Stainless steel thermodes (2 x 2 mm) were used to cool (20
degrees C) and thereby create neuronal dysfunction of discrete VMS sites.
Bilateral cooling under anesthesia 0-2 or 2-4 mm lateral to the midline
between the exit of cranial nerves VI and XII resulted in a reduction (P
< 0.05) of breathing and most often in apnea. Cooling caudal or rostral
to this area did not have a consistent effect on breathing. In 7-day-old
goats (n = 8), 3 x 3-mm thermodes were chronically implanted bilaterally on
the VMS surface between the exit of cranial nerves VI and XII. The goats
recovered and were studied over several days thereafter. VMS cooling while
the goats were awake caused breathing to decrease (P < 0.05), but apnea
was never observed. The decrease was less (P < 0.05) than while the
goats were anesthetized. After 10 s of cooling, the hypopnea while the
goats were awake was uniform during eupnea, hypercapnia, hyperoxia, and
hypoxia, but after 10 s of cooling, the decrease was relatively greater (P
< 0.05) during hyperoxia and hypercapnia. These effects of VMS cooling
are qualitatively the same as in adult goats; thus the data are consistent
with mature VMS contribution to the control of breathing in neonatal goats.</description><subject>Animals</subject><subject>Animals, Newborn - physiology</subject><subject>Biological and medical sciences</subject><subject>Cardiorespiratory control. Arterial mecano- and chemoreceptor</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medulla Oblongata - physiology</subject><subject>Respiration - physiology</subject><subject>Sheep</subject><subject>Temperature</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS0EKqXwByBlgRCbBDt-Zomq8lIlNrC2HMduU6VxsBNQ_x6HVhWrGememTtzAbhGMEOI5g8b1XVNhoqCZQJmLHakOAHTKOUpYhCdgqngFKacCn4OLkLYQIgIoWgCJkJAJopiCt4W1hrdJ65NSm9Uv67bVeJs8m3a3qsm2ZpqaBrld0kYvFXaJNq5ZoTqNmmNa1UfqZVTfbgEZ1Y1wVwd6gx8Pi0-5i_p8v35df64TDVmpE8pJaUSxNrRuOSGQFRBpjhkmmOicIUUJbgyFOYVQ5gSTjFklBWlgkJjgWfgbr-38-5rMKGX2zpoE6-M9wxBcoFzkiMSQbIHtXcheGNl5-tt_EUiKMcI5V-EcoxQCiiZHCOMYzeH_UMZ3z8OHTKL-u1BV0GrxnrV6jocMYwY5QRH7H6PrevV-qf2RnbrXahd41a70fif4y_lWojm</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Lowry, T. F</creator><creator>Forster, H. V</creator><creator>Pan, L. G</creator><creator>Ohtake, P. J</creator><creator>Epshteyn, I</creator><creator>Korducki, M. J</creator><creator>Franciosi, R. A</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Effect on breathing of ventral medullary surface cooling in neonatal goats</title><author>Lowry, T. F ; Forster, H. V ; Pan, L. G ; Ohtake, P. J ; Epshteyn, I ; Korducki, M. J ; Franciosi, R. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-554ba84ffffecb7e401d06a706c734a3d1a543de502d6135475306569ba08c383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Animals, Newborn - physiology</topic><topic>Biological and medical sciences</topic><topic>Cardiorespiratory control. Arterial mecano- and chemoreceptor</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medulla Oblongata - physiology</topic><topic>Respiration - physiology</topic><topic>Sheep</topic><topic>Temperature</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lowry, T. F</creatorcontrib><creatorcontrib>Forster, H. V</creatorcontrib><creatorcontrib>Pan, L. G</creatorcontrib><creatorcontrib>Ohtake, P. J</creatorcontrib><creatorcontrib>Epshteyn, I</creatorcontrib><creatorcontrib>Korducki, M. J</creatorcontrib><creatorcontrib>Franciosi, R. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lowry, T. F</au><au>Forster, H. V</au><au>Pan, L. G</au><au>Ohtake, P. J</au><au>Epshteyn, I</au><au>Korducki, M. J</au><au>Franciosi, R. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect on breathing of ventral medullary surface cooling in neonatal goats</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>80</volume><issue>6</issue><spage>1949</spage><epage>1957</epage><pages>1949-1957</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>T. F. Lowry, H. V. Forster, L. G. Pan, P. J. Ohtake, I. Epshteyn, M. J. Korducki and R. A. Franciosi
Department of Physiology, Medical College of Wisconsin, Milwaukee, USA.
The present study was designed to determine whether neurons near the
ventral medullary surface (VMS) that are important to control of breathing
in adult mammals are also important to control of breathing in neonates. In
7-day-old goats (n = 22), the VMS was surgically exposed under halothane
anesthesia. Stainless steel thermodes (2 x 2 mm) were used to cool (20
degrees C) and thereby create neuronal dysfunction of discrete VMS sites.
Bilateral cooling under anesthesia 0-2 or 2-4 mm lateral to the midline
between the exit of cranial nerves VI and XII resulted in a reduction (P
< 0.05) of breathing and most often in apnea. Cooling caudal or rostral
to this area did not have a consistent effect on breathing. In 7-day-old
goats (n = 8), 3 x 3-mm thermodes were chronically implanted bilaterally on
the VMS surface between the exit of cranial nerves VI and XII. The goats
recovered and were studied over several days thereafter. VMS cooling while
the goats were awake caused breathing to decrease (P < 0.05), but apnea
was never observed. The decrease was less (P < 0.05) than while the
goats were anesthetized. After 10 s of cooling, the hypopnea while the
goats were awake was uniform during eupnea, hypercapnia, hyperoxia, and
hypoxia, but after 10 s of cooling, the decrease was relatively greater (P
< 0.05) during hyperoxia and hypercapnia. These effects of VMS cooling
are qualitatively the same as in adult goats; thus the data are consistent
with mature VMS contribution to the control of breathing in neonatal goats.</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>8806899</pmid><doi>10.1152/jappl.1996.80.6.1949</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Animals, Newborn - physiology Biological and medical sciences Cardiorespiratory control. Arterial mecano- and chemoreceptor Female Fundamental and applied biological sciences. Psychology Male Medulla Oblongata - physiology Respiration - physiology Sheep Temperature Vertebrates: respiratory system |
| title | Effect on breathing of ventral medullary surface cooling in neonatal goats |
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