Activation of c-Jun-NH2-Kinase by UV Irradiation Is Dependent on p21ras

We have demonstrated previously that Jun-NH 2 -kinase (JNK) activation in vitro is potentiated by association with the p21 ras protein. To determine if in vivo activation of JNK also depends on p21 ras , we have used M1311 cells that carry the cDNA for the neutralizing antibody to p21 ras , Y13-259,...

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Veröffentlicht in:	The Journal of biological chemistry 1996-09, Vol.271 (38), p.23304
Hauptverfasser:	Adler, V, Pincus, M R, Polotskaya, A, Montano, X, Friedman, F K, Ronai, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium-Calmodulin-Dependent Protein Kinases - radiation effects Enzyme Activation - radiation effects Gene Expression Regulation JNK Mitogen-Activated Protein Kinases Mice Mitogen-Activated Protein Kinases Neutralization Tests Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - immunology Proto-Oncogene Proteins p21(ras) - metabolism Transcription, Genetic Transfection Ultraviolet Rays
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