Serum Factors Inhibit Melanoma Cell Surface Expression of Type I and Type II IGF Receptors

Abstract We have identified one class of IGF-I-binding sites and two classes of IGF-II-binding sites at the surface of the melanoma cell line IGR39. By means of affinity labeling with 125I-IGF-I, a 290-300 kDa form was characterized. Using 125I-IGF-II, a 270 kDa polypeptide was labeled, correspondin...

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Veröffentlicht in:	Journal of receptors and signal transduction 1996, Vol.16 (1-2), p.115-134
Hauptverfasser:	Bellan, C., Remacle-Bonnet, M., Garrouste, F., Secchi, J., Luis, J., Pommier, G., Marvaldi, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels - metabolism Binding Sites Binding, Competitive Blood Proteins - pharmacology Blotting, Western Cell Line Culture Media, Serum-Free Gene Expression Regulation, Neoplastic - drug effects Humans Melanoma - metabolism Receptor, IGF Type 1 - biosynthesis Receptor, IGF Type 2 - biosynthesis
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