Differential modulation of protein kinase C isozymes in rat parotid acinar cells: Relation to amylase secretion

We investigated the expression, distribution, and activation parameters of protein kinase C (PKC) isozymes in isolated rat parotid acinar cells. By analyzing cellular extracts by western blot analysis and for isozyme-specific RNA, the Ca 2+independent PKC-δ, -ϵ, and -ζ were detected in the cytosolic...

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Veröffentlicht in:	Biochemical pharmacology 1996-08, Vol.52 (4), p.569-577
Hauptverfasser:	Terzian, A.Roger, Zhang, Xuejun, Rubin, Ronald P.
Format:	Artikel
Sprache:	eng
Schlagworte:	amylase secretion Animals Biological and medical sciences Blotting, Western Fundamental and applied biological sciences. Psychology Isoenzymes - drug effects isozyme-specific mRNA Male Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus parotid acinar cells Parotid Gland - drug effects phorbol esters Phorbol Esters - pharmacology Polymerase Chain Reaction protein kinase C Protein Kinase C - drug effects protein kinase C inhibitors Rats Rats, Sprague-Dawley substance P Vertebrates: digestive system
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