Effects of Acute Cardioselective and non-selective beta-adrenergic Blockade on Plasma Ammonia Levels in Exercising Dogs
The aim of this study was to assess plasma ammonia levels during acute treadmill exercise in dogs after intravenous administration of a single dose of different cardioselective (atenolol) and non-selective (sotalol and propranolol) β-adrenergic blocking drugs. The experiments were performed on 6 mal...
Gespeichert in:
| Veröffentlicht in: | Archives of physiology and biochemistry 1996, Vol.104 (1), p.14-19 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 19 |
|---|---|
| container_issue | 1 |
| container_start_page | 14 |
| container_title | Archives of physiology and biochemistry |
| container_volume | 104 |
| creator | Matthys, D Calders, P Kint, J Pannier, J L |
| description | The aim of this study was to assess plasma ammonia levels during acute treadmill exercise in dogs after intravenous administration of a single dose of different cardioselective (atenolol) and non-selective (sotalol and propranolol) β-adrenergic blocking drugs. The experiments were performed on 6 male mongrel dogs (20-25 kg) trained to run on a motor driven treadmill. After administration of saline or atenolol, there was no significant increase in plasma ammonia during exercise; propranolol and sotalol however, both non-selective β-blockers, produced a significant increase in plasma ammonia. Plasma levels of alanine and glutamine were not altered during exercise compared with resting values, and were not modified by the administration of β-blockers. It is not clear whether the different effects on exercise induced hyperammonemia are due to different effects on muscle ammonia formation or on the ammonia clearance by the liver. |
| doi_str_mv | 10.1076/apab.104.1.14.12872 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_8724875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78150659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-ac539a94d50f43d0700dbf7c220434273cada86f49e7be37bb035f1124a01f453</originalsourceid><addsrcrecordid>eNp9kE9vEzEQxVcIVErhEyAkHxC3DfbaG-8eQEpD-CNFggOcrVl7nLp47WDvtvTb4yihiEsv49HM7z2NX1W9ZHTBqFy-hT0MpRMLtmClNJ1sHlXnTApRC7akj0vPO1Zz0bZPq2c5X1NaoJ6dVWcFFZ1sz6vbjbWop0yiJSs9T0jWkIyLGX0ZuxskEAwJMdT_JgNOUINJGDDtnCaXPuqfYJDEQL55yCOQ1TjG4IBs8QZ9Ji6QzW9M2mUXduRD3OXn1RMLPuOL03tR_fi4-b7-XG-_fvqyXm1rLXg31aBb3kMvTEut4IZKSs1gpW4aKrhoJNdgoFta0aMckMthoLy1jDUCKLOi5RfVm6PvPsVfM-ZJjS5r9B4Cxjkr2bGWLtu-gPwI6hRzTmjVPrkR0p1iVB3iVoe4SycUU6yUQ9xF9epkPw8jmnvNKd-yf33aQ9bgbYJQQrjHOO1l3_CCvT9iLtiYRriNyRs1wZ2P6a-GP3zHu_8MrhD8dKUhobqOcwol4gf_8QcbrrKu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78150659</pqid></control><display><type>article</type><title>Effects of Acute Cardioselective and non-selective beta-adrenergic Blockade on Plasma Ammonia Levels in Exercising Dogs</title><source>Taylor & Francis</source><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><creator>Matthys, D ; Calders, P ; Kint, J ; Pannier, J L</creator><creatorcontrib>Matthys, D ; Calders, P ; Kint, J ; Pannier, J L</creatorcontrib><description>The aim of this study was to assess plasma ammonia levels during acute treadmill exercise in dogs after intravenous administration of a single dose of different cardioselective (atenolol) and non-selective (sotalol and propranolol) β-adrenergic blocking drugs. The experiments were performed on 6 male mongrel dogs (20-25 kg) trained to run on a motor driven treadmill. After administration of saline or atenolol, there was no significant increase in plasma ammonia during exercise; propranolol and sotalol however, both non-selective β-blockers, produced a significant increase in plasma ammonia. Plasma levels of alanine and glutamine were not altered during exercise compared with resting values, and were not modified by the administration of β-blockers. It is not clear whether the different effects on exercise induced hyperammonemia are due to different effects on muscle ammonia formation or on the ammonia clearance by the liver.</description><identifier>ISSN: 1381-3455</identifier><identifier>EISSN: 1744-4160</identifier><identifier>DOI: 10.1076/apab.104.1.14.12872</identifier><identifier>PMID: 8724875</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Ammonia - blood ; Animals ; Anti-Arrhythmia Agents - pharmacology ; Atenolol - pharmacology ; Biological and medical sciences ; Catecholaminergic system ; Dogs ; Drug Evaluation, Preclinical ; Evaluation Studies as Topic ; Heart Rate - drug effects ; Infusions, Intravenous ; Male ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Physical Conditioning, Animal - physiology ; Propranolol - pharmacology ; Sotalol - pharmacology</subject><ispartof>Archives of physiology and biochemistry, 1996, Vol.104 (1), p.14-19</ispartof><rights>1996 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-ac539a94d50f43d0700dbf7c220434273cada86f49e7be37bb035f1124a01f453</citedby><cites>FETCH-LOGICAL-c438t-ac539a94d50f43d0700dbf7c220434273cada86f49e7be37bb035f1124a01f453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1076/apab.104.1.14.12872$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1076/apab.104.1.14.12872$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,4010,4036,4037,23909,23910,25118,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3097923$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8724875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matthys, D</creatorcontrib><creatorcontrib>Calders, P</creatorcontrib><creatorcontrib>Kint, J</creatorcontrib><creatorcontrib>Pannier, J L</creatorcontrib><title>Effects of Acute Cardioselective and non-selective beta-adrenergic Blockade on Plasma Ammonia Levels in Exercising Dogs</title><title>Archives of physiology and biochemistry</title><addtitle>Arch Physiol Biochem</addtitle><description>The aim of this study was to assess plasma ammonia levels during acute treadmill exercise in dogs after intravenous administration of a single dose of different cardioselective (atenolol) and non-selective (sotalol and propranolol) β-adrenergic blocking drugs. The experiments were performed on 6 male mongrel dogs (20-25 kg) trained to run on a motor driven treadmill. After administration of saline or atenolol, there was no significant increase in plasma ammonia during exercise; propranolol and sotalol however, both non-selective β-blockers, produced a significant increase in plasma ammonia. Plasma levels of alanine and glutamine were not altered during exercise compared with resting values, and were not modified by the administration of β-blockers. It is not clear whether the different effects on exercise induced hyperammonemia are due to different effects on muscle ammonia formation or on the ammonia clearance by the liver.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Ammonia - blood</subject><subject>Animals</subject><subject>Anti-Arrhythmia Agents - pharmacology</subject><subject>Atenolol - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Dogs</subject><subject>Drug Evaluation, Preclinical</subject><subject>Evaluation Studies as Topic</subject><subject>Heart Rate - drug effects</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Propranolol - pharmacology</subject><subject>Sotalol - pharmacology</subject><issn>1381-3455</issn><issn>1744-4160</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9vEzEQxVcIVErhEyAkHxC3DfbaG-8eQEpD-CNFggOcrVl7nLp47WDvtvTb4yihiEsv49HM7z2NX1W9ZHTBqFy-hT0MpRMLtmClNJ1sHlXnTApRC7akj0vPO1Zz0bZPq2c5X1NaoJ6dVWcFFZ1sz6vbjbWop0yiJSs9T0jWkIyLGX0ZuxskEAwJMdT_JgNOUINJGDDtnCaXPuqfYJDEQL55yCOQ1TjG4IBs8QZ9Ji6QzW9M2mUXduRD3OXn1RMLPuOL03tR_fi4-b7-XG-_fvqyXm1rLXg31aBb3kMvTEut4IZKSs1gpW4aKrhoJNdgoFta0aMckMthoLy1jDUCKLOi5RfVm6PvPsVfM-ZJjS5r9B4Cxjkr2bGWLtu-gPwI6hRzTmjVPrkR0p1iVB3iVoe4SycUU6yUQ9xF9epkPw8jmnvNKd-yf33aQ9bgbYJQQrjHOO1l3_CCvT9iLtiYRriNyRs1wZ2P6a-GP3zHu_8MrhD8dKUhobqOcwol4gf_8QcbrrKu</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Matthys, D</creator><creator>Calders, P</creator><creator>Kint, J</creator><creator>Pannier, J L</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Effects of Acute Cardioselective and non-selective beta-adrenergic Blockade on Plasma Ammonia Levels in Exercising Dogs</title><author>Matthys, D ; Calders, P ; Kint, J ; Pannier, J L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-ac539a94d50f43d0700dbf7c220434273cada86f49e7be37bb035f1124a01f453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Ammonia - blood</topic><topic>Animals</topic><topic>Anti-Arrhythmia Agents - pharmacology</topic><topic>Atenolol - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Catecholaminergic system</topic><topic>Dogs</topic><topic>Drug Evaluation, Preclinical</topic><topic>Evaluation Studies as Topic</topic><topic>Heart Rate - drug effects</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Propranolol - pharmacology</topic><topic>Sotalol - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matthys, D</creatorcontrib><creatorcontrib>Calders, P</creatorcontrib><creatorcontrib>Kint, J</creatorcontrib><creatorcontrib>Pannier, J L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matthys, D</au><au>Calders, P</au><au>Kint, J</au><au>Pannier, J L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Acute Cardioselective and non-selective beta-adrenergic Blockade on Plasma Ammonia Levels in Exercising Dogs</atitle><jtitle>Archives of physiology and biochemistry</jtitle><addtitle>Arch Physiol Biochem</addtitle><date>1996</date><risdate>1996</risdate><volume>104</volume><issue>1</issue><spage>14</spage><epage>19</epage><pages>14-19</pages><issn>1381-3455</issn><eissn>1744-4160</eissn><abstract>The aim of this study was to assess plasma ammonia levels during acute treadmill exercise in dogs after intravenous administration of a single dose of different cardioselective (atenolol) and non-selective (sotalol and propranolol) β-adrenergic blocking drugs. The experiments were performed on 6 male mongrel dogs (20-25 kg) trained to run on a motor driven treadmill. After administration of saline or atenolol, there was no significant increase in plasma ammonia during exercise; propranolol and sotalol however, both non-selective β-blockers, produced a significant increase in plasma ammonia. Plasma levels of alanine and glutamine were not altered during exercise compared with resting values, and were not modified by the administration of β-blockers. It is not clear whether the different effects on exercise induced hyperammonemia are due to different effects on muscle ammonia formation or on the ammonia clearance by the liver.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>8724875</pmid><doi>10.1076/apab.104.1.14.12872</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1381-3455 |
| ispartof | Archives of physiology and biochemistry, 1996, Vol.104 (1), p.14-19 |
| issn | 1381-3455 1744-4160 |
| language | eng |
| recordid | cdi_pubmed_primary_8724875 |
| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Adrenergic beta-Antagonists - pharmacology Ammonia - blood Animals Anti-Arrhythmia Agents - pharmacology Atenolol - pharmacology Biological and medical sciences Catecholaminergic system Dogs Drug Evaluation, Preclinical Evaluation Studies as Topic Heart Rate - drug effects Infusions, Intravenous Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Physical Conditioning, Animal - physiology Propranolol - pharmacology Sotalol - pharmacology |
| title | Effects of Acute Cardioselective and non-selective beta-adrenergic Blockade on Plasma Ammonia Levels in Exercising Dogs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T12%3A02%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Acute%20Cardioselective%20and%20non-selective%20beta-adrenergic%20Blockade%20on%20Plasma%20Ammonia%20Levels%20in%20Exercising%20Dogs&rft.jtitle=Archives%20of%20physiology%20and%20biochemistry&rft.au=Matthys,%20D&rft.date=1996&rft.volume=104&rft.issue=1&rft.spage=14&rft.epage=19&rft.pages=14-19&rft.issn=1381-3455&rft.eissn=1744-4160&rft_id=info:doi/10.1076/apab.104.1.14.12872&rft_dat=%3Cproquest_pubme%3E78150659%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78150659&rft_id=info:pmid/8724875&rfr_iscdi=true |