Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children : comparison of four anesthetic techniques using nitrous oxide with halothane or propofol
The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children. Eighty unpremedica...
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| Veröffentlicht in: | Anesthesiology (Philadelphia) 1996-07, Vol.85 (1), p.4-10 |
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| creator | VED, S. A WALDEN, T. L MONTANA, J LEA, D. E TEFFT, M. C KATARIA, B. K PUDIMAT, M. A NICODEMUS, H. F MILMOE, G. J |
| description | The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children.
Eighty unpremedicated children, aged 3-10 yr, were assigned randomly to four groups: group H/H, 0.5-2% halothane induction/halothane maintenance; group P/P, 3-5 mg.kg-1 propofol induction and 0.1-0.3 mg.kg-1.min-1 propofol maintenance; group H/P, 0.1-0.3 mg.kg-1.min-1 halothane induction/propofol maintenance; and group P/H, 3-5 mg.kg-1 propofol induction and 0.5-2% halothane maintenance. Nitrous oxide (67%) and oxygen (33%) were administered in all the groups. Other treatments and procedures were standardized intra- and postoperatively. Results of postoperative vomiting and recovery were analyzed in the first 6 h and beyond 6 h.
Logistic regression showed that vomiting occurred 3.5 times as often when halothane was used for maintenance of anesthesia (groups H/H and P/H) compared with the use of propofol (groups P/P and H/P; Odds Ratio 3.5; 95% confidence interval 1.3 and 9.4, respectively; P = 0.012). A significant association between vomiting ( < 6 h: yes/no) and discharge times ( > 6 h: yes/no) (Odd's Ratio = 3.6; 95% confidence interval: 1.02, 12.4, respectively) (P = 0.046) was shown. However, no significant differences among the groups in the incidence of vomiting beyond 6 h, recurrent vomiting, or hospital discharge times were shown.
After tonsillectomy and adenoidectomy procedures, despite reduced postoperative vomiting with use of propofol rather than halothane, along with nitrous oxide for anesthetic maintenance, the authors found no differences in "true" endpoints such as unplanned admissions or discharge times. Among the groups, the main factor that delayed hospital discharge beyond 6 h was vomiting within the first 6 h. |
| doi_str_mv | 10.1097/00000542-199607000-00002 |
| format | Article |
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Eighty unpremedicated children, aged 3-10 yr, were assigned randomly to four groups: group H/H, 0.5-2% halothane induction/halothane maintenance; group P/P, 3-5 mg.kg-1 propofol induction and 0.1-0.3 mg.kg-1.min-1 propofol maintenance; group H/P, 0.1-0.3 mg.kg-1.min-1 halothane induction/propofol maintenance; and group P/H, 3-5 mg.kg-1 propofol induction and 0.5-2% halothane maintenance. Nitrous oxide (67%) and oxygen (33%) were administered in all the groups. Other treatments and procedures were standardized intra- and postoperatively. Results of postoperative vomiting and recovery were analyzed in the first 6 h and beyond 6 h.
Logistic regression showed that vomiting occurred 3.5 times as often when halothane was used for maintenance of anesthesia (groups H/H and P/H) compared with the use of propofol (groups P/P and H/P; Odds Ratio 3.5; 95% confidence interval 1.3 and 9.4, respectively; P = 0.012). A significant association between vomiting ( < 6 h: yes/no) and discharge times ( > 6 h: yes/no) (Odd's Ratio = 3.6; 95% confidence interval: 1.02, 12.4, respectively) (P = 0.046) was shown. However, no significant differences among the groups in the incidence of vomiting beyond 6 h, recurrent vomiting, or hospital discharge times were shown.
After tonsillectomy and adenoidectomy procedures, despite reduced postoperative vomiting with use of propofol rather than halothane, along with nitrous oxide for anesthetic maintenance, the authors found no differences in "true" endpoints such as unplanned admissions or discharge times. Among the groups, the main factor that delayed hospital discharge beyond 6 h was vomiting within the first 6 h.</description><identifier>ISSN: 0003-3022</identifier><identifier>EISSN: 1528-1175</identifier><identifier>DOI: 10.1097/00000542-199607000-00002</identifier><identifier>PMID: 8694380</identifier><identifier>CODEN: ANESAV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adenoidectomy ; Anesthesia - adverse effects ; Anesthesia - methods ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Halothane - administration & dosage ; Halothane - adverse effects ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Humans ; Male ; Medical sciences ; Nitrous Oxide - administration & dosage ; Nitrous Oxide - adverse effects ; Postoperative Complications - prevention & control ; Propofol - adverse effects ; Prospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the upper aerodigestive tract ; Tonsillectomy ; Vomiting - epidemiology ; Vomiting - prevention & control</subject><ispartof>Anesthesiology (Philadelphia), 1996-07, Vol.85 (1), p.4-10</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3140538$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8694380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VED, S. A</creatorcontrib><creatorcontrib>WALDEN, T. L</creatorcontrib><creatorcontrib>MONTANA, J</creatorcontrib><creatorcontrib>LEA, D. E</creatorcontrib><creatorcontrib>TEFFT, M. C</creatorcontrib><creatorcontrib>KATARIA, B. K</creatorcontrib><creatorcontrib>PUDIMAT, M. A</creatorcontrib><creatorcontrib>NICODEMUS, H. F</creatorcontrib><creatorcontrib>MILMOE, G. J</creatorcontrib><title>Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children : comparison of four anesthetic techniques using nitrous oxide with halothane or propofol</title><title>Anesthesiology (Philadelphia)</title><addtitle>Anesthesiology</addtitle><description>The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children.
Eighty unpremedicated children, aged 3-10 yr, were assigned randomly to four groups: group H/H, 0.5-2% halothane induction/halothane maintenance; group P/P, 3-5 mg.kg-1 propofol induction and 0.1-0.3 mg.kg-1.min-1 propofol maintenance; group H/P, 0.1-0.3 mg.kg-1.min-1 halothane induction/propofol maintenance; and group P/H, 3-5 mg.kg-1 propofol induction and 0.5-2% halothane maintenance. Nitrous oxide (67%) and oxygen (33%) were administered in all the groups. Other treatments and procedures were standardized intra- and postoperatively. Results of postoperative vomiting and recovery were analyzed in the first 6 h and beyond 6 h.
Logistic regression showed that vomiting occurred 3.5 times as often when halothane was used for maintenance of anesthesia (groups H/H and P/H) compared with the use of propofol (groups P/P and H/P; Odds Ratio 3.5; 95% confidence interval 1.3 and 9.4, respectively; P = 0.012). A significant association between vomiting ( < 6 h: yes/no) and discharge times ( > 6 h: yes/no) (Odd's Ratio = 3.6; 95% confidence interval: 1.02, 12.4, respectively) (P = 0.046) was shown. However, no significant differences among the groups in the incidence of vomiting beyond 6 h, recurrent vomiting, or hospital discharge times were shown.
After tonsillectomy and adenoidectomy procedures, despite reduced postoperative vomiting with use of propofol rather than halothane, along with nitrous oxide for anesthetic maintenance, the authors found no differences in "true" endpoints such as unplanned admissions or discharge times. Among the groups, the main factor that delayed hospital discharge beyond 6 h was vomiting within the first 6 h.</description><subject>Adenoidectomy</subject><subject>Anesthesia - adverse effects</subject><subject>Anesthesia - methods</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Halothane - administration & dosage</subject><subject>Halothane - adverse effects</subject><subject>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitrous Oxide - administration & dosage</subject><subject>Nitrous Oxide - adverse effects</subject><subject>Postoperative Complications - prevention & control</subject><subject>Propofol - adverse effects</subject><subject>Prospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the upper aerodigestive tract</subject><subject>Tonsillectomy</subject><subject>Vomiting - epidemiology</subject><subject>Vomiting - prevention & control</subject><issn>0003-3022</issn><issn>1528-1175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMlO5DAQtUaDmgbmE5DqMNeAHceJMzfUGhYJiQtwRY4XYpS4MrYD9D_xkaSZFnUp1dtKeoQAo2eMts053Y2oyoK1bU2b5Sh2SPmDrJkoZcFYI36S9QLxgtOyPCRHKb0sZyO4XJGVrNuKS7omH484-uzDM6hgIFqNrzZuQblsI-CcJ5W9DRkyhuSHweqM4_ZLq4wN6M0e8QF07wcTbYA_oHGcVPQJA6ADh3NcLDbl3mavIVvdB_9vtgnmtHsdfI44J8D3JQ_efO6hVwPmfjEBRpgiTuhwOCEHTg3J_trvY_Jw-fd-c13c3l3dbC5ui4nVTS6UVk4aKRpWsVpR2bpOdKUxgvOWys4yXfNO81LXznHFjJCuLRshed1UdaclPyan_3OnuRuteZqiH1XcPu1bW_jfe14lrQYXVdA-fcs4q-hSM_8EX2WCvA</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>VED, S. A</creator><creator>WALDEN, T. L</creator><creator>MONTANA, J</creator><creator>LEA, D. E</creator><creator>TEFFT, M. C</creator><creator>KATARIA, B. K</creator><creator>PUDIMAT, M. A</creator><creator>NICODEMUS, H. F</creator><creator>MILMOE, G. J</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19960701</creationdate><title>Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children : comparison of four anesthetic techniques using nitrous oxide with halothane or propofol</title><author>VED, S. A ; WALDEN, T. L ; MONTANA, J ; LEA, D. E ; TEFFT, M. C ; KATARIA, B. K ; PUDIMAT, M. A ; NICODEMUS, H. F ; MILMOE, G. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p167t-acaf8d8571416a089fb5b2dd533908be1c63bc32c6ff3a1d58f9275836746bc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenoidectomy</topic><topic>Anesthesia - adverse effects</topic><topic>Anesthesia - methods</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Halothane - administration & dosage</topic><topic>Halothane - adverse effects</topic><topic>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitrous Oxide - administration & dosage</topic><topic>Nitrous Oxide - adverse effects</topic><topic>Postoperative Complications - prevention & control</topic><topic>Propofol - adverse effects</topic><topic>Prospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the upper aerodigestive tract</topic><topic>Tonsillectomy</topic><topic>Vomiting - epidemiology</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VED, S. A</creatorcontrib><creatorcontrib>WALDEN, T. L</creatorcontrib><creatorcontrib>MONTANA, J</creatorcontrib><creatorcontrib>LEA, D. E</creatorcontrib><creatorcontrib>TEFFT, M. C</creatorcontrib><creatorcontrib>KATARIA, B. K</creatorcontrib><creatorcontrib>PUDIMAT, M. A</creatorcontrib><creatorcontrib>NICODEMUS, H. F</creatorcontrib><creatorcontrib>MILMOE, G. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Anesthesiology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VED, S. A</au><au>WALDEN, T. L</au><au>MONTANA, J</au><au>LEA, D. E</au><au>TEFFT, M. C</au><au>KATARIA, B. K</au><au>PUDIMAT, M. A</au><au>NICODEMUS, H. F</au><au>MILMOE, G. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children : comparison of four anesthetic techniques using nitrous oxide with halothane or propofol</atitle><jtitle>Anesthesiology (Philadelphia)</jtitle><addtitle>Anesthesiology</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>85</volume><issue>1</issue><spage>4</spage><epage>10</epage><pages>4-10</pages><issn>0003-3022</issn><eissn>1528-1175</eissn><coden>ANESAV</coden><abstract>The authors' purpose in this study was to compare prospectively four different anesthetic induction and maintenance techniques using nitrous oxide with halothane and/or propofol for vomiting and recovery after outpatient tonsillectomy and adenoidectomy procedures in children.
Eighty unpremedicated children, aged 3-10 yr, were assigned randomly to four groups: group H/H, 0.5-2% halothane induction/halothane maintenance; group P/P, 3-5 mg.kg-1 propofol induction and 0.1-0.3 mg.kg-1.min-1 propofol maintenance; group H/P, 0.1-0.3 mg.kg-1.min-1 halothane induction/propofol maintenance; and group P/H, 3-5 mg.kg-1 propofol induction and 0.5-2% halothane maintenance. Nitrous oxide (67%) and oxygen (33%) were administered in all the groups. Other treatments and procedures were standardized intra- and postoperatively. Results of postoperative vomiting and recovery were analyzed in the first 6 h and beyond 6 h.
Logistic regression showed that vomiting occurred 3.5 times as often when halothane was used for maintenance of anesthesia (groups H/H and P/H) compared with the use of propofol (groups P/P and H/P; Odds Ratio 3.5; 95% confidence interval 1.3 and 9.4, respectively; P = 0.012). A significant association between vomiting ( < 6 h: yes/no) and discharge times ( > 6 h: yes/no) (Odd's Ratio = 3.6; 95% confidence interval: 1.02, 12.4, respectively) (P = 0.046) was shown. However, no significant differences among the groups in the incidence of vomiting beyond 6 h, recurrent vomiting, or hospital discharge times were shown.
After tonsillectomy and adenoidectomy procedures, despite reduced postoperative vomiting with use of propofol rather than halothane, along with nitrous oxide for anesthetic maintenance, the authors found no differences in "true" endpoints such as unplanned admissions or discharge times. Among the groups, the main factor that delayed hospital discharge beyond 6 h was vomiting within the first 6 h.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>8694380</pmid><doi>10.1097/00000542-199607000-00002</doi><tpages>7</tpages></addata></record> |
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| ispartof | Anesthesiology (Philadelphia), 1996-07, Vol.85 (1), p.4-10 |
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| language | eng |
| recordid | cdi_pubmed_primary_8694380 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adenoidectomy Anesthesia - adverse effects Anesthesia - methods Biological and medical sciences Child Child, Preschool Female Halothane - administration & dosage Halothane - adverse effects Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Humans Male Medical sciences Nitrous Oxide - administration & dosage Nitrous Oxide - adverse effects Postoperative Complications - prevention & control Propofol - adverse effects Prospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the upper aerodigestive tract Tonsillectomy Vomiting - epidemiology Vomiting - prevention & control |
| title | Vomiting and recovery after outpatient tonsillectomy and adenoidectomy in children : comparison of four anesthetic techniques using nitrous oxide with halothane or propofol |
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