Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats
To evaluate the effects of absorption enhancers in dry powders and in liquids, pulmonary absorption of salmon calcitonin (sCT) in various formulations was measured. The dry powder of sCT was prepared by a freeze-drying method with a jet mill. After intratracheal administration of sCT dry powder and...
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| Veröffentlicht in: | Pharmaceutical research 1996, Vol.13 (1), p.80-83 |
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| creator | KOBAYASHI, S KONDO, S JUNI, K |
| description | To evaluate the effects of absorption enhancers in dry powders and in liquids, pulmonary absorption of salmon calcitonin (sCT) in various formulations was measured.
The dry powder of sCT was prepared by a freeze-drying method with a jet mill. After intratracheal administration of sCT dry powder and liquid (solution) preparations to rats, plasma sCT levels and calcium levels were measured.
After intratracheal administration without absorption enhancers, sCT in the dry powder and in the liquid were absorbed nearly to the same degree. Absorption enhancers (oleic acid, lecithin, citric acid, taurocholic acid, dimethyl-beta-cyclodextrin, octyl-beta-D-glucoside) were much more effective in the dry powder than in the solution. The reason may be that the enhancers added to the dry powder dissolved at high concentrations in a trace volume of the fluid lining the alveolar epithelium.
The present results suggest that the pulmonary absorption of peptides and proteins can be greatly improved by formulating them into dry powders with smaller amounts of enhancers than in liquid dosage forms. |
| doi_str_mv | 10.1023/A:1016081301369 |
| format | Article |
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The dry powder of sCT was prepared by a freeze-drying method with a jet mill. After intratracheal administration of sCT dry powder and liquid (solution) preparations to rats, plasma sCT levels and calcium levels were measured.
After intratracheal administration without absorption enhancers, sCT in the dry powder and in the liquid were absorbed nearly to the same degree. Absorption enhancers (oleic acid, lecithin, citric acid, taurocholic acid, dimethyl-beta-cyclodextrin, octyl-beta-D-glucoside) were much more effective in the dry powder than in the solution. The reason may be that the enhancers added to the dry powder dissolved at high concentrations in a trace volume of the fluid lining the alveolar epithelium.
The present results suggest that the pulmonary absorption of peptides and proteins can be greatly improved by formulating them into dry powders with smaller amounts of enhancers than in liquid dosage forms.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/A:1016081301369</identifier><identifier>PMID: 8668684</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Absorption ; Animals ; Biological and medical sciences ; Calcitonin - blood ; Calcitonin - pharmacokinetics ; Dextrans ; Drug Synergism ; Evaluation Studies as Topic ; Fluorescein-5-isothiocyanate - analogs & derivatives ; General pharmacology ; Intubation, Intratracheal ; Lung - metabolism ; Male ; Medical sciences ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Powders ; Pulmonary Alveoli - metabolism ; Rats ; Rats, Sprague-Dawley ; Solutions</subject><ispartof>Pharmaceutical research, 1996, Vol.13 (1), p.80-83</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-da8a2350a837d32ad915f81357bd45a0c37f70eaba18983b763e963667109cf13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2992140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8668684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOBAYASHI, S</creatorcontrib><creatorcontrib>KONDO, S</creatorcontrib><creatorcontrib>JUNI, K</creatorcontrib><title>Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>To evaluate the effects of absorption enhancers in dry powders and in liquids, pulmonary absorption of salmon calcitonin (sCT) in various formulations was measured.
The dry powder of sCT was prepared by a freeze-drying method with a jet mill. After intratracheal administration of sCT dry powder and liquid (solution) preparations to rats, plasma sCT levels and calcium levels were measured.
After intratracheal administration without absorption enhancers, sCT in the dry powder and in the liquid were absorbed nearly to the same degree. Absorption enhancers (oleic acid, lecithin, citric acid, taurocholic acid, dimethyl-beta-cyclodextrin, octyl-beta-D-glucoside) were much more effective in the dry powder than in the solution. The reason may be that the enhancers added to the dry powder dissolved at high concentrations in a trace volume of the fluid lining the alveolar epithelium.
The present results suggest that the pulmonary absorption of peptides and proteins can be greatly improved by formulating them into dry powders with smaller amounts of enhancers than in liquid dosage forms.</description><subject>Absorption</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcitonin - blood</subject><subject>Calcitonin - pharmacokinetics</subject><subject>Dextrans</subject><subject>Drug Synergism</subject><subject>Evaluation Studies as Topic</subject><subject>Fluorescein-5-isothiocyanate - analogs & derivatives</subject><subject>General pharmacology</subject><subject>Intubation, Intratracheal</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Powders</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Solutions</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j01Lw0AQhhdRaq2ePQk5eI3OZDf74a2U-gEFPSgIHspkd6MraRKyqeK_d4vF0wzv8zDMy9g5whVCwa_nNwgoQSMH5NIcsCmWiucGxOshm4IqRK6VwGN2EuMnQBKNmLCJllJLLabs7WnbbLqWhp_M-SZ8-bR0dRZpl2aWGhvGrg1t5hLou2_nh5jZrh0ppPQ9oyp2Qz-GJPv2g1q740kfaIyn7KimJvqz_Zyxl9vl8-I-Xz3ePSzmq9wWGsfckaaCl0CaK8cLcgbLOhUqVeVESWC5qhV4qgi10bxSknsjuZQKwdga-Yxd_N3tt9XGu3U_hE0qtN6XTPxyzymmRvWQ3gzxXyuMKVAA_wUdN2Gh</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>KOBAYASHI, S</creator><creator>KONDO, S</creator><creator>JUNI, K</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1996</creationdate><title>Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats</title><author>KOBAYASHI, S ; KONDO, S ; JUNI, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-da8a2350a837d32ad915f81357bd45a0c37f70eaba18983b763e963667109cf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcitonin - blood</topic><topic>Calcitonin - pharmacokinetics</topic><topic>Dextrans</topic><topic>Drug Synergism</topic><topic>Evaluation Studies as Topic</topic><topic>Fluorescein-5-isothiocyanate - analogs & derivatives</topic><topic>General pharmacology</topic><topic>Intubation, Intratracheal</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Powders</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Solutions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOBAYASHI, S</creatorcontrib><creatorcontrib>KONDO, S</creatorcontrib><creatorcontrib>JUNI, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOBAYASHI, S</au><au>KONDO, S</au><au>JUNI, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1996</date><risdate>1996</risdate><volume>13</volume><issue>1</issue><spage>80</spage><epage>83</epage><pages>80-83</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>To evaluate the effects of absorption enhancers in dry powders and in liquids, pulmonary absorption of salmon calcitonin (sCT) in various formulations was measured.
The dry powder of sCT was prepared by a freeze-drying method with a jet mill. After intratracheal administration of sCT dry powder and liquid (solution) preparations to rats, plasma sCT levels and calcium levels were measured.
After intratracheal administration without absorption enhancers, sCT in the dry powder and in the liquid were absorbed nearly to the same degree. Absorption enhancers (oleic acid, lecithin, citric acid, taurocholic acid, dimethyl-beta-cyclodextrin, octyl-beta-D-glucoside) were much more effective in the dry powder than in the solution. The reason may be that the enhancers added to the dry powder dissolved at high concentrations in a trace volume of the fluid lining the alveolar epithelium.
The present results suggest that the pulmonary absorption of peptides and proteins can be greatly improved by formulating them into dry powders with smaller amounts of enhancers than in liquid dosage forms.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>8668684</pmid><doi>10.1023/A:1016081301369</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Pharmaceutical research, 1996, Vol.13 (1), p.80-83 |
| issn | 0724-8741 1573-904X |
| language | eng |
| recordid | cdi_pubmed_primary_8668684 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Absorption Animals Biological and medical sciences Calcitonin - blood Calcitonin - pharmacokinetics Dextrans Drug Synergism Evaluation Studies as Topic Fluorescein-5-isothiocyanate - analogs & derivatives General pharmacology Intubation, Intratracheal Lung - metabolism Male Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Powders Pulmonary Alveoli - metabolism Rats Rats, Sprague-Dawley Solutions |
| title | Pulmonary delivery of salmon calcitonin dry powders containing absorption enhancers in rats |
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