Somatic in Vivo alterations of the DPC4 gene at 18q21 in human lung cancers
The chromosome region 18q21 has been shown to be frequently deleted in lung cancers. Recent identification at this locus of DPC4, a gene whose inactivation has been suggested to play a role in pancreatic carcinogenesis, prompted as to examine whether it might also be altered in lung cancers. Two mis...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1996-06, Vol.56 (12), p.2718-2720 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | NAGATAKE, M TAKAGI, Y OSADA, H UCHIDA, K MITSUDOMI, T SAJI, S SHIMOKATA, K TAKAHASHI, TOSHITADA TAKAHASHI, TAKASHI |
| description | The chromosome region 18q21 has been shown to be frequently deleted in lung cancers. Recent identification at this locus of DPC4, a gene whose inactivation has been suggested to play a role in pancreatic carcinogenesis, prompted as to examine whether it might also be altered in lung cancers. Two missense and 2-bp frameshift somatic mutations in DPC4 were detected among 42 lung cancer specimens taken directly from patients. DPC4 mutations, however, were not present in all lung cancers carrying l8q21 deletions. These findings suggest that DPC4 may play a role in a limited fraction of lung cancers and that another tumor suppressor gene may also exist in this chromosome region. |
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Recent identification at this locus of DPC4, a gene whose inactivation has been suggested to play a role in pancreatic carcinogenesis, prompted as to examine whether it might also be altered in lung cancers. Two missense and 2-bp frameshift somatic mutations in DPC4 were detected among 42 lung cancer specimens taken directly from patients. DPC4 mutations, however, were not present in all lung cancers carrying l8q21 deletions. 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Recent identification at this locus of DPC4, a gene whose inactivation has been suggested to play a role in pancreatic carcinogenesis, prompted as to examine whether it might also be altered in lung cancers. Two missense and 2-bp frameshift somatic mutations in DPC4 were detected among 42 lung cancer specimens taken directly from patients. DPC4 mutations, however, were not present in all lung cancers carrying l8q21 deletions. These findings suggest that DPC4 may play a role in a limited fraction of lung cancers and that another tumor suppressor gene may also exist in this chromosome region.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>Chromosomes, Human, Pair 18 - genetics</subject><subject>DNA-Binding Proteins</subject><subject>Gene Deletion</subject><subject>Genes, Tumor Suppressor - genetics</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Pneumology</subject><subject>Polymerase Chain Reaction</subject><subject>Proteins - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Smad4 Protein</subject><subject>Trans-Activators</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLxDAQhYMoa139CUIefC1Mbk36KPWy4oKCl9dlmibbSpuuTSv4761YfDrMOR_DzDkiCVPCpFpKdUwSADCpkpqfkrMYP-ZRMVArsjJZphSwhDy-9B2OjaVNoO_NV0-xHd0wO32ItPd0rB29eS4k3bvgKI6UmU_Oful66jDQdgp7ajFYN8RzcuKxje5i0TV5u7t9LTbp9un-objepjXP8jF1ANLnuhLaawSDuXPGlsZKCQg5lK6UglVcc5BC5xqYF2CBs8xUOVdYiTW5_Nt7mMrOVbvD0HQ4fO-Wp-b8askxWmz9MJ_XxH9MMDBzP-IHjl9TYw</recordid><startdate>19960615</startdate><enddate>19960615</enddate><creator>NAGATAKE, M</creator><creator>TAKAGI, Y</creator><creator>OSADA, H</creator><creator>UCHIDA, K</creator><creator>MITSUDOMI, T</creator><creator>SAJI, S</creator><creator>SHIMOKATA, K</creator><creator>TAKAHASHI, TOSHITADA</creator><creator>TAKAHASHI, TAKASHI</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19960615</creationdate><title>Somatic in Vivo alterations of the DPC4 gene at 18q21 in human lung cancers</title><author>NAGATAKE, M ; TAKAGI, Y ; OSADA, H ; UCHIDA, K ; MITSUDOMI, T ; SAJI, S ; SHIMOKATA, K ; TAKAHASHI, TOSHITADA ; TAKAHASHI, TAKASHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-e004f97d37f7a08a9ee8cb8c440a090beb431d27204379701f30c02168d925ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>Chromosomes, Human, Pair 18 - genetics</topic><topic>DNA-Binding Proteins</topic><topic>Gene Deletion</topic><topic>Genes, Tumor Suppressor - genetics</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Pneumology</topic><topic>Polymerase Chain Reaction</topic><topic>Proteins - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Smad4 Protein</topic><topic>Trans-Activators</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAGATAKE, M</creatorcontrib><creatorcontrib>TAKAGI, Y</creatorcontrib><creatorcontrib>OSADA, H</creatorcontrib><creatorcontrib>UCHIDA, K</creatorcontrib><creatorcontrib>MITSUDOMI, T</creatorcontrib><creatorcontrib>SAJI, S</creatorcontrib><creatorcontrib>SHIMOKATA, K</creatorcontrib><creatorcontrib>TAKAHASHI, TOSHITADA</creatorcontrib><creatorcontrib>TAKAHASHI, TAKASHI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAGATAKE, M</au><au>TAKAGI, Y</au><au>OSADA, H</au><au>UCHIDA, K</au><au>MITSUDOMI, T</au><au>SAJI, S</au><au>SHIMOKATA, K</au><au>TAKAHASHI, TOSHITADA</au><au>TAKAHASHI, TAKASHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatic in Vivo alterations of the DPC4 gene at 18q21 in human lung cancers</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1996-06-15</date><risdate>1996</risdate><volume>56</volume><issue>12</issue><spage>2718</spage><epage>2720</epage><pages>2718-2720</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>The chromosome region 18q21 has been shown to be frequently deleted in lung cancers. Recent identification at this locus of DPC4, a gene whose inactivation has been suggested to play a role in pancreatic carcinogenesis, prompted as to examine whether it might also be altered in lung cancers. Two missense and 2-bp frameshift somatic mutations in DPC4 were detected among 42 lung cancer specimens taken directly from patients. DPC4 mutations, however, were not present in all lung cancers carrying l8q21 deletions. These findings suggest that DPC4 may play a role in a limited fraction of lung cancers and that another tumor suppressor gene may also exist in this chromosome region.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>8665501</pmid><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 1996-06, Vol.56 (12), p.2718-2720 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Base Sequence Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Small Cell - genetics Chromosomes, Human, Pair 18 - genetics DNA-Binding Proteins Gene Deletion Genes, Tumor Suppressor - genetics Humans Lung Neoplasms - genetics Medical sciences Molecular Sequence Data Pneumology Polymerase Chain Reaction Proteins - genetics Sequence Analysis, DNA Smad4 Protein Trans-Activators Tumors of the respiratory system and mediastinum |
| title | Somatic in Vivo alterations of the DPC4 gene at 18q21 in human lung cancers |
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