An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity

We have previously demonstrated that a chimeric protein composed of human IL-4 and Pseudomonas exotoxin, termed IL4-PE4E, is cytotoxic to primary cells derived from human renal cell carcinoma (RCC). To improve the cytotoxicity of IL4-toxins such as IL4-PE4E and IL4-PE38KDEL to IL-4 receptor (IL-4R)...

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Veröffentlicht in:	Cellular immunology 1996-07, Vol.171 (1), p.80
Hauptverfasser:	Puri, R K, Leland, P, Obiri, N I, Husain, S R, Mule, J, Pastan, I, Kreitman, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases Bacterial Toxins - genetics Bacterial Toxins - immunology Bacterial Toxins - toxicity Bone Marrow - metabolism Bone Marrow Cells Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - immunology Colony-Forming Units Assay Exotoxins - genetics Exotoxins - toxicity Flow Cytometry Humans Interleukin-4 - genetics Interleukin-4 - immunology Interleukin-4 - toxicity Kidney Neoplasms - genetics Kidney Neoplasms - immunology Protein Binding - immunology Pseudomonas aeruginosa - immunology Pseudomonas aeruginosa Exotoxin A Receptors, Interleukin-2 - biosynthesis Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - toxicity Transfection - immunology Tumor Cells, Cultured Virulence Factors
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