Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity

Human P450 2C19 is selective for 4'-hydroxylation of S-mephenytoin and 5-hydroxylation of omeprazole, while the structurally homologous P450 2C9 has low activity toward these substrates. To identify the critical amino acids that determine the specificity of human amino acids that determine the...

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Veröffentlicht in:	The Journal of biological chemistry 1996-05, Vol.271 (21), p.12496
Hauptverfasser:	Ibeanu, G C, Ghanayem, B I, Linko, P, Li, L, Pederson, L G, Goldstein, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aryl Hydrocarbon Hydroxylases Base Sequence Cytochrome P-450 CYP2C19 Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Humans Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - metabolism Molecular Sequence Data Mutagenesis, Site-Directed Oligodeoxyribonucleotides Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism
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