Single-dose azithromycin in the treatment of trachoma : A randomized, controlled study
To compare the safety and efficacy of single oral-dose azithromycin with a 7-week topical tetracycline ointment course in the treatment of active trachoma. A total of 64 patients with active trachoma were selected randomly to receive azithromycin (20 mg/kg) in a single dose or topical tetracycline e...
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| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 1996-05, Vol.103 (5), p.842-846 |
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| container_title | Ophthalmology (Rochester, Minn.) |
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| creator | TABBARA, K. F EL-ASRAR, A. M. A AL-OMAR, O CHOUDHURY, A. H AL-FAISAL, Z |
| description | To compare the safety and efficacy of single oral-dose azithromycin with a 7-week topical tetracycline ointment course in the treatment of active trachoma.
A total of 64 patients with active trachoma were selected randomly to receive azithromycin (20 mg/kg) in a single dose or topical tetracycline eye ointment for 6 weeks. Clinical assessments were made before and at 4, 8, 12, and 24 weeks after treatment. Conjunctival scrapings were obtained before and after 24 weeks after treatment and fixed for Giemsa and direct immunofluorescence staining.
Trachoma resolved in 17 (63.3%) patients who received azithromycin compared with 19 (65.4%) who were treated with tetracycline ointment. There were no significant differences in treatment effect or baseline characteristics between the treatment groups. Both treatments were well tolerated, and no adverse events were noted.
Single-dose azithromycin is as effective as a 6-week course of topical tetracycline ointment in the treatment of active trachoma. The findings may help establish high compliance in treating trachoma and could contribute to the control of trachoma worldwide. |
| doi_str_mv | 10.1016/S0161-6420(96)30605-2 |
| format | Article |
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A total of 64 patients with active trachoma were selected randomly to receive azithromycin (20 mg/kg) in a single dose or topical tetracycline eye ointment for 6 weeks. Clinical assessments were made before and at 4, 8, 12, and 24 weeks after treatment. Conjunctival scrapings were obtained before and after 24 weeks after treatment and fixed for Giemsa and direct immunofluorescence staining.
Trachoma resolved in 17 (63.3%) patients who received azithromycin compared with 19 (65.4%) who were treated with tetracycline ointment. There were no significant differences in treatment effect or baseline characteristics between the treatment groups. Both treatments were well tolerated, and no adverse events were noted.
Single-dose azithromycin is as effective as a 6-week course of topical tetracycline ointment in the treatment of active trachoma. The findings may help establish high compliance in treating trachoma and could contribute to the control of trachoma worldwide.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(96)30605-2</identifier><identifier>PMID: 8637698</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Administration, Oral ; Adolescent ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; Azithromycin - administration & dosage ; Azithromycin - adverse effects ; Azithromycin - therapeutic use ; Biological and medical sciences ; Child ; Conjunctiva - pathology ; Eye ; Humans ; Medical sciences ; Ointments ; Pharmacology. Drug treatments ; Safety ; Saudi Arabia - epidemiology ; Single-Blind Method ; Tetracycline - administration & dosage ; Tetracycline - therapeutic use ; Trachoma - drug therapy ; Trachoma - epidemiology ; Trachoma - pathology ; Tropical medicine</subject><ispartof>Ophthalmology (Rochester, Minn.), 1996-05, Vol.103 (5), p.842-846</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3091587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8637698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TABBARA, K. F</creatorcontrib><creatorcontrib>EL-ASRAR, A. M. A</creatorcontrib><creatorcontrib>AL-OMAR, O</creatorcontrib><creatorcontrib>CHOUDHURY, A. H</creatorcontrib><creatorcontrib>AL-FAISAL, Z</creatorcontrib><title>Single-dose azithromycin in the treatment of trachoma : A randomized, controlled study</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To compare the safety and efficacy of single oral-dose azithromycin with a 7-week topical tetracycline ointment course in the treatment of active trachoma.
A total of 64 patients with active trachoma were selected randomly to receive azithromycin (20 mg/kg) in a single dose or topical tetracycline eye ointment for 6 weeks. Clinical assessments were made before and at 4, 8, 12, and 24 weeks after treatment. Conjunctival scrapings were obtained before and after 24 weeks after treatment and fixed for Giemsa and direct immunofluorescence staining.
Trachoma resolved in 17 (63.3%) patients who received azithromycin compared with 19 (65.4%) who were treated with tetracycline ointment. There were no significant differences in treatment effect or baseline characteristics between the treatment groups. Both treatments were well tolerated, and no adverse events were noted.
Single-dose azithromycin is as effective as a 6-week course of topical tetracycline ointment in the treatment of active trachoma. The findings may help establish high compliance in treating trachoma and could contribute to the control of trachoma worldwide.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Azithromycin - administration & dosage</subject><subject>Azithromycin - adverse effects</subject><subject>Azithromycin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Conjunctiva - pathology</subject><subject>Eye</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Ointments</subject><subject>Pharmacology. Drug treatments</subject><subject>Safety</subject><subject>Saudi Arabia - epidemiology</subject><subject>Single-Blind Method</subject><subject>Tetracycline - administration & dosage</subject><subject>Tetracycline - therapeutic use</subject><subject>Trachoma - drug therapy</subject><subject>Trachoma - epidemiology</subject><subject>Trachoma - pathology</subject><subject>Tropical medicine</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j09LAzEQxYMotVY_QiEHDwpGk81mduOtFP9BwUPVa5kmE7uyuym76aH99C5YhGEej99jeMPYVMl7JRU8LIelBOSZvLFwqyVII7ITNlYmtyIvlD5l4__IObvo-x8pJYDOR2xUgi7AlmP2taza75qEjz1xPFRp08Vm76qWD5M2xFNHmBpqE49hMOg2sUH-yGe8w9bHpjqQv-MutqmLdU2e92nn95fsLGDd09VRJ-zz-elj_ioW7y9v89lCbDNtkvDOkXNF7v0afFYaBwosSEmogiaENVqiQsrgjQnW2AKdJ_BSmUAeKegJm_7d3e7WDfnVtqsa7Par438Dvz5y7B3WYejsqv4_pqVVpiz0LzDAYhM</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>TABBARA, K. 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H ; AL-FAISAL, Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-dccecc74ddb6d285c6169600ea1f3ea6ba9ee700fd55f9597acde6d015fedaef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Azithromycin - administration & dosage</topic><topic>Azithromycin - adverse effects</topic><topic>Azithromycin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Conjunctiva - pathology</topic><topic>Eye</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Ointments</topic><topic>Pharmacology. Drug treatments</topic><topic>Safety</topic><topic>Saudi Arabia - epidemiology</topic><topic>Single-Blind Method</topic><topic>Tetracycline - administration & dosage</topic><topic>Tetracycline - therapeutic use</topic><topic>Trachoma - drug therapy</topic><topic>Trachoma - epidemiology</topic><topic>Trachoma - pathology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TABBARA, K. F</creatorcontrib><creatorcontrib>EL-ASRAR, A. M. A</creatorcontrib><creatorcontrib>AL-OMAR, O</creatorcontrib><creatorcontrib>CHOUDHURY, A. 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H</au><au>AL-FAISAL, Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-dose azithromycin in the treatment of trachoma : A randomized, controlled study</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>103</volume><issue>5</issue><spage>842</spage><epage>846</epage><pages>842-846</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>To compare the safety and efficacy of single oral-dose azithromycin with a 7-week topical tetracycline ointment course in the treatment of active trachoma.
A total of 64 patients with active trachoma were selected randomly to receive azithromycin (20 mg/kg) in a single dose or topical tetracycline eye ointment for 6 weeks. Clinical assessments were made before and at 4, 8, 12, and 24 weeks after treatment. Conjunctival scrapings were obtained before and after 24 weeks after treatment and fixed for Giemsa and direct immunofluorescence staining.
Trachoma resolved in 17 (63.3%) patients who received azithromycin compared with 19 (65.4%) who were treated with tetracycline ointment. There were no significant differences in treatment effect or baseline characteristics between the treatment groups. Both treatments were well tolerated, and no adverse events were noted.
Single-dose azithromycin is as effective as a 6-week course of topical tetracycline ointment in the treatment of active trachoma. The findings may help establish high compliance in treating trachoma and could contribute to the control of trachoma worldwide.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>8637698</pmid><doi>10.1016/S0161-6420(96)30605-2</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0161-6420 |
| ispartof | Ophthalmology (Rochester, Minn.), 1996-05, Vol.103 (5), p.842-846 |
| issn | 0161-6420 1549-4713 |
| language | eng |
| recordid | cdi_pubmed_primary_8637698 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Adolescent Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Azithromycin - administration & dosage Azithromycin - adverse effects Azithromycin - therapeutic use Biological and medical sciences Child Conjunctiva - pathology Eye Humans Medical sciences Ointments Pharmacology. Drug treatments Safety Saudi Arabia - epidemiology Single-Blind Method Tetracycline - administration & dosage Tetracycline - therapeutic use Trachoma - drug therapy Trachoma - epidemiology Trachoma - pathology Tropical medicine |
| title | Single-dose azithromycin in the treatment of trachoma : A randomized, controlled study |
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