The ALIAmide Palmitoylethanolamide and Cannabinoids, but not Anandamide, are Protective in a Delayed Postglutamate Paradigm of Excitotoxic Death in Cerebellar Granule Neurons

The amino acid L-glutamate is a neurotrans-mitter that mediates fast neuronal excitation in a majority of synapses in the central nervous system. Glutamate stimulates both N-methyl-D-aspartate (NMDA) and non-NMDA receptors. While activation of NMDA receptors has been implicated in a variety of neuro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-04, Vol.93 (9), p.3984-3989
Hauptverfasser:	Skaper, S. D., Buriani, A., Toso, R. Dal, Petrelli, L., Romanello, S., Facci, L., Leon, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Arachidonic Acids - pharmacology Base Sequence Behavioral neuroscience Cannabinoid receptors Cannabinoids Cannabinoids - biosynthesis Cells, Cultured Cerebellum - cytology Cultured cells Dizocilpine Maleate - pharmacology Endocannabinoids Ethanolamines Glutamic Acid - toxicity In Situ Hybridization Kinetics Mast cells Messenger RNA Mice Mice, Inbred BALB C Models, Neurological Molecular Sequence Data N-Methylaspartate - pharmacology Neurology Neurons Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotoxicity Neurotoxins - toxicity Oligonucleotide Probes Palmitic Acids - pharmacology Polyunsaturated Alkamides Receptors Receptors, Cannabinoid Receptors, Drug - biosynthesis Receptors, Drug - drug effects Receptors, Drug - physiology RNA, Messenger - analysis RNA, Messenger - biosynthesis Rodents Time Factors
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