Life span and tumours in the first-generation offspring of the gamma-irradiated male mouse
C57BL/6 male mice were exposed to 3 Gy 60Co gammarays and mated with unirradiated females after 15 days to produce F1 progeny produced following irradiation of the spermatids. After weaning the offsprings were allowed to live their normal life span. The mean litter size of the irradiated group signi...
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| Veröffentlicht in: | International journal of radiation biology 1996-04, Vol.69 (4), p.487-492 |
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| container_title | International journal of radiation biology |
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| creator | IWASAKI, T. |
| description | C57BL/6 male mice were exposed to 3 Gy 60Co gammarays and mated with unirradiated females after 15 days to produce F1 progeny produced following irradiation of the spermatids. After weaning the offsprings were allowed to live their normal life span. The mean litter size of the irradiated group significantly decreased from 7. 1 to 4.9 (p < 0.01), but the sex ratio was not altered by the irradiation. No significant differences in the survival curve and mean life-span between the irradiated and control groups were noted. The only radiation effect in tumour incidence was a decrease of histiocytic sarcoma in female offspring of irradiated males. Except for this, there were no significant differences between the irradiated group and the control group in the incidence or age distribution of tumours. |
| doi_str_mv | 10.1080/095530096145788 |
| format | Article |
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After weaning the offsprings were allowed to live their normal life span. The mean litter size of the irradiated group significantly decreased from 7. 1 to 4.9 (p < 0.01), but the sex ratio was not altered by the irradiation. No significant differences in the survival curve and mean life-span between the irradiated and control groups were noted. The only radiation effect in tumour incidence was a decrease of histiocytic sarcoma in female offspring of irradiated males. 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After weaning the offsprings were allowed to live their normal life span. The mean litter size of the irradiated group significantly decreased from 7. 1 to 4.9 (p < 0.01), but the sex ratio was not altered by the irradiation. No significant differences in the survival curve and mean life-span between the irradiated and control groups were noted. The only radiation effect in tumour incidence was a decrease of histiocytic sarcoma in female offspring of irradiated males. Except for this, there were no significant differences between the irradiated group and the control group in the incidence or age distribution of tumours.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Female</subject><subject>Litter Size</subject><subject>Lymphoma, Large B-Cell, Diffuse - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>Paternal Exposure</subject><subject>Physical agents</subject><subject>Sex Ratio</subject><subject>Tumors</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Uc9LHDEYDcWiW9tzT0IO0tvUL5PNTMZbkWoLC720l16Gb5J8u5GZzJpkEf_7RncVLHjKI-8HLy-MfRbwVYCGC-iUkgBdI5aq1fodWwjZ1JUs90ds8cgWDPUJ-5DSLRQEUh-zY93UrZBiwf6uPDmethg4Bsvzbpp3MXEfeN44Tj6mXK1dcBGznwOfidI2-rAu6EmxxmnCyseI1mN2lk84Ol5CkvvI3hOOyX06nKfsz_X331c_qtWvm59X31aVWSqZKyk02eVgpR1Ea42otW01wNC0ROA0NdZYGjQ0kshaaRSB6iQMLZkOO1LylH3Z527jfLdzKfeTT8aNIwZXevRC6WapoS7Ci73QxDml6KgvT5kwPvQC-sc1-__WLI6zQ_RumJx90R_mK_z5gcdkcKSIwfj0IpNCqOYp5nIv84HmOOH9HEfbZ3wY5_jskW936F6ZNw7HvDEYXX9b_iqUad_s_w_OmKHQ</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>IWASAKI, T.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19960401</creationdate><title>Life span and tumours in the first-generation offspring of the gamma-irradiated male mouse</title><author>IWASAKI, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-318fd4bd3db17dc128d7800b67ff0e8f6dcdfb8063ffdd3c5f05930b7fc9a9f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Female</topic><topic>Litter Size</topic><topic>Lymphoma, Large B-Cell, Diffuse - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>Paternal Exposure</topic><topic>Physical agents</topic><topic>Sex Ratio</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IWASAKI, T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IWASAKI, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Life span and tumours in the first-generation offspring of the gamma-irradiated male mouse</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>69</volume><issue>4</issue><spage>487</spage><epage>492</epage><pages>487-492</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>C57BL/6 male mice were exposed to 3 Gy 60Co gammarays and mated with unirradiated females after 15 days to produce F1 progeny produced following irradiation of the spermatids. After weaning the offsprings were allowed to live their normal life span. The mean litter size of the irradiated group significantly decreased from 7. 1 to 4.9 (p < 0.01), but the sex ratio was not altered by the irradiation. No significant differences in the survival curve and mean life-span between the irradiated and control groups were noted. The only radiation effect in tumour incidence was a decrease of histiocytic sarcoma in female offspring of irradiated males. Except for this, there were no significant differences between the irradiated group and the control group in the incidence or age distribution of tumours.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>8627131</pmid><doi>10.1080/095530096145788</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0955-3002 |
| ispartof | International journal of radiation biology, 1996-04, Vol.69 (4), p.487-492 |
| issn | 0955-3002 1362-3095 |
| language | eng |
| recordid | cdi_pubmed_primary_8627131 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Female Litter Size Lymphoma, Large B-Cell, Diffuse - etiology Male Medical sciences Mice Mice, Inbred C57BL Neoplasms, Radiation-Induced - etiology Paternal Exposure Physical agents Sex Ratio Tumors |
| title | Life span and tumours in the first-generation offspring of the gamma-irradiated male mouse |
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