The expression of the MDM2 gene, a p53 binding protein, in thyroid carcinogenesis

Background. The authors previously found p53 mutations in 24% of malignant thyroid tumors, representing a wide staging spectrum. Overexpression of MDM2, most often due to gene amplification, has ben suggested to be ab additional mechanism for abrogation of the p53 function. In the current study. MDM...

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