Mazindol for Relapse Prevention to Cocaine Abuse in Methadone-Maintained Patients
We conducted a double-blind, randomized clinical trial of mazindol (n = 37) for the prevention of relapse to cocaine abuse in methadone-maintained patients who were in the "action" stage of change, i.e., had a history of cocaine dependence but who had been abstinent for at least 2 weeks pr...
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| Veröffentlicht in: | The American journal of drug and alcohol abuse 1995-01, Vol.21 (4), p.469-481 |
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| container_title | The American journal of drug and alcohol abuse |
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| creator | Margolin, Arthur Avants, S. Kelly Kosten, Thomas R |
| description | We conducted a double-blind, randomized clinical trial of mazindol (n = 37) for the prevention of relapse to cocaine abuse in methadone-maintained patients who were in the "action" stage of change, i.e., had a history of cocaine dependence but who had been abstinent for at least 2 weeks prior to entry into the study. Eight-one percent of subjects completed the 12-week course of treatment. Overall, cocaine use during the study was comparatively low-17% of the urine screens submitted were positive for cocaine metabolite. Differences between the mazindol and placebo groups of rates of relapse, number of days to relapse, and cocaine use did not reach statistical significance, but were in the direction of a treatment effect. Results suggest that stage of abstinence initiation may be a potentially useful category to employ as an independent variable in future pharmacotherapy trials for the treatment of cocaine addiction in this patient population. |
| doi_str_mv | 10.3109/00952999509002711 |
| format | Article |
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Kelly ; Kosten, Thomas R</creator><creatorcontrib>Margolin, Arthur ; Avants, S. Kelly ; Kosten, Thomas R</creatorcontrib><description>We conducted a double-blind, randomized clinical trial of mazindol (n = 37) for the prevention of relapse to cocaine abuse in methadone-maintained patients who were in the "action" stage of change, i.e., had a history of cocaine dependence but who had been abstinent for at least 2 weeks prior to entry into the study. Eight-one percent of subjects completed the 12-week course of treatment. Overall, cocaine use during the study was comparatively low-17% of the urine screens submitted were positive for cocaine metabolite. Differences between the mazindol and placebo groups of rates of relapse, number of days to relapse, and cocaine use did not reach statistical significance, but were in the direction of a treatment effect. Results suggest that stage of abstinence initiation may be a potentially useful category to employ as an independent variable in future pharmacotherapy trials for the treatment of cocaine addiction in this patient population.</description><identifier>ISSN: 0095-2990</identifier><identifier>EISSN: 1097-9891</identifier><identifier>DOI: 10.3109/00952999509002711</identifier><identifier>PMID: 8561098</identifier><identifier>CODEN: AJDABD</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Cocaine ; Combined Modality Therapy ; Double-Blind Method ; Drug addiction ; Drug therapy ; Drug Therapy, Combination ; Female ; Humans ; Male ; Mazindol - administration & dosage ; Mazindol - therapeutic use ; Methadone - therapeutic use ; Narcotic Antagonists - administration & dosage ; Narcotic Antagonists - therapeutic use ; Psychotherapy ; Recurrence ; Substance abuse treatment ; Substance-Related Disorders - drug therapy ; Substance-Related Disorders - therapy</subject><ispartof>The American journal of drug and alcohol abuse, 1995-01, Vol.21 (4), p.469-481</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>Copyright Marcel Dekker, Inc. Nov 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-a6ed34cfb485b10423e314b6809b9ade33e490e57fd90d042268137869323be53</citedby><cites>FETCH-LOGICAL-c428t-a6ed34cfb485b10423e314b6809b9ade33e490e57fd90d042268137869323be53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00952999509002711$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00952999509002711$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,31003,33778,59651,59757,60440,60546,61225,61260,61406,61441</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8561098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Margolin, Arthur</creatorcontrib><creatorcontrib>Avants, S. Kelly</creatorcontrib><creatorcontrib>Kosten, Thomas R</creatorcontrib><title>Mazindol for Relapse Prevention to Cocaine Abuse in Methadone-Maintained Patients</title><title>The American journal of drug and alcohol abuse</title><addtitle>Am J Drug Alcohol Abuse</addtitle><description>We conducted a double-blind, randomized clinical trial of mazindol (n = 37) for the prevention of relapse to cocaine abuse in methadone-maintained patients who were in the "action" stage of change, i.e., had a history of cocaine dependence but who had been abstinent for at least 2 weeks prior to entry into the study. Eight-one percent of subjects completed the 12-week course of treatment. Overall, cocaine use during the study was comparatively low-17% of the urine screens submitted were positive for cocaine metabolite. Differences between the mazindol and placebo groups of rates of relapse, number of days to relapse, and cocaine use did not reach statistical significance, but were in the direction of a treatment effect. Results suggest that stage of abstinence initiation may be a potentially useful category to employ as an independent variable in future pharmacotherapy trials for the treatment of cocaine addiction in this patient population.</description><subject>Adult</subject><subject>Cocaine</subject><subject>Combined Modality Therapy</subject><subject>Double-Blind Method</subject><subject>Drug addiction</subject><subject>Drug therapy</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mazindol - administration & dosage</subject><subject>Mazindol - therapeutic use</subject><subject>Methadone - therapeutic use</subject><subject>Narcotic Antagonists - administration & dosage</subject><subject>Narcotic Antagonists - therapeutic use</subject><subject>Psychotherapy</subject><subject>Recurrence</subject><subject>Substance abuse treatment</subject><subject>Substance-Related Disorders - drug therapy</subject><subject>Substance-Related Disorders - therapy</subject><issn>0095-2990</issn><issn>1097-9891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>BHHNA</sourceid><recordid>eNp1kEtLAzEUhYMotT5-gAthcD-aTOaRoJtSfEGLVXQ9ZCZ3aMo0qUlGqb_eDC2KSO8mcL9zziUHoTOCLynB_ApjniWc8wxzjJOCkD00DPsi5oyTfTTseRwE-BAdObfAGBNWpAM0YFkedGyInqfiS2lp2qgxNnqBVqwcRDMLH6C9MjryJhqbWigN0ajqAlM6moKfC2k0xNMAfA9lNBNeBY87QQeNaB2cbt9j9HZ3-zp-iCdP94_j0SSu04T5WOQgaVo3VcqyiuA0oUBJWuUM84oLCZRCyjFkRSM5loEnOSO0YDmnCa0go8foYpO7sua9A-fLhemsDifLhHBKszBBRDai2hrnLDTlyqqlsOuS4LKvsPxXYfCcb4O7agnyx7HtLPCbDVc6dLYUn8a2svRi3RrbWKFr5fro3fHXf-xzEK2f18LC7wd2u78BucSPqw</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>Margolin, Arthur</creator><creator>Avants, S. Kelly</creator><creator>Kosten, Thomas R</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7U3</scope><scope>BHHNA</scope><scope>K7.</scope><scope>K9.</scope></search><sort><creationdate>19950101</creationdate><title>Mazindol for Relapse Prevention to Cocaine Abuse in Methadone-Maintained Patients</title><author>Margolin, Arthur ; Avants, S. Kelly ; Kosten, Thomas R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-a6ed34cfb485b10423e314b6809b9ade33e490e57fd90d042268137869323be53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Cocaine</topic><topic>Combined Modality Therapy</topic><topic>Double-Blind Method</topic><topic>Drug addiction</topic><topic>Drug therapy</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mazindol - administration & dosage</topic><topic>Mazindol - therapeutic use</topic><topic>Methadone - therapeutic use</topic><topic>Narcotic Antagonists - administration & dosage</topic><topic>Narcotic Antagonists - therapeutic use</topic><topic>Psychotherapy</topic><topic>Recurrence</topic><topic>Substance abuse treatment</topic><topic>Substance-Related Disorders - drug therapy</topic><topic>Substance-Related Disorders - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Margolin, Arthur</creatorcontrib><creatorcontrib>Avants, S. Kelly</creatorcontrib><creatorcontrib>Kosten, Thomas R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Social Services Abstracts</collection><collection>Sociological Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>The American journal of drug and alcohol abuse</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Margolin, Arthur</au><au>Avants, S. Kelly</au><au>Kosten, Thomas R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mazindol for Relapse Prevention to Cocaine Abuse in Methadone-Maintained Patients</atitle><jtitle>The American journal of drug and alcohol abuse</jtitle><addtitle>Am J Drug Alcohol Abuse</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>21</volume><issue>4</issue><spage>469</spage><epage>481</epage><pages>469-481</pages><issn>0095-2990</issn><eissn>1097-9891</eissn><coden>AJDABD</coden><abstract>We conducted a double-blind, randomized clinical trial of mazindol (n = 37) for the prevention of relapse to cocaine abuse in methadone-maintained patients who were in the "action" stage of change, i.e., had a history of cocaine dependence but who had been abstinent for at least 2 weeks prior to entry into the study. Eight-one percent of subjects completed the 12-week course of treatment. Overall, cocaine use during the study was comparatively low-17% of the urine screens submitted were positive for cocaine metabolite. Differences between the mazindol and placebo groups of rates of relapse, number of days to relapse, and cocaine use did not reach statistical significance, but were in the direction of a treatment effect. Results suggest that stage of abstinence initiation may be a potentially useful category to employ as an independent variable in future pharmacotherapy trials for the treatment of cocaine addiction in this patient population.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>8561098</pmid><doi>10.3109/00952999509002711</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0095-2990 |
| ispartof | The American journal of drug and alcohol abuse, 1995-01, Vol.21 (4), p.469-481 |
| issn | 0095-2990 1097-9891 |
| language | eng |
| recordid | cdi_pubmed_primary_8561098 |
| source | MEDLINE; Sociological Abstracts; Applied Social Sciences Index & Abstracts (ASSIA); Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Adult Cocaine Combined Modality Therapy Double-Blind Method Drug addiction Drug therapy Drug Therapy, Combination Female Humans Male Mazindol - administration & dosage Mazindol - therapeutic use Methadone - therapeutic use Narcotic Antagonists - administration & dosage Narcotic Antagonists - therapeutic use Psychotherapy Recurrence Substance abuse treatment Substance-Related Disorders - drug therapy Substance-Related Disorders - therapy |
| title | Mazindol for Relapse Prevention to Cocaine Abuse in Methadone-Maintained Patients |
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