Receptor-Mediated Gene Transfer into Macrophages

Gene transfer systems targeting various receptors have been developed to introduce functional genes into cells in culture and into intact animals. A synthetic molecular conjugate, consisting of mannosylated polylysine that exploits endocytosis via the macrophage mannose receptor, was constructed and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-01, Vol.93 (1), p.101-105
Hauptverfasser:	Ferkol, Thomas, Perales, Jose C., Mularo, Frank, Hanson, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Disease DNA DNA - administration & dosage Escherichia coli Gene Transfer Techniques Genes Glycoproteins Hepatocytes Lectins, C-Type Liver Luciferases - genetics Macrophages Macrophages - metabolism Mannose-Binding Lectins Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Photinus pyralis Plasmids Polylysine - chemistry Receptors Receptors, Cell Surface - metabolism Spleen Transfection Transgenes
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