Trimethoprim-Sulfamethoxazole for Scleritis Associated with Limited Wegenerʼs Granulomatosis: Use of Histopathology and Anti-neutrophil Cytoplasmic Antibody (ANCA) Test
Ophthalmic involvement may be noted in ≤ 58% of Wegenerʼs granulomatosis cases, scleritis being one of the most frequent and potentially devastating manifestations. Cytotoxic immunosuppressive drug therapy is effective treatment for this disorder but potentially highly toxic. Recent uncontrolled and...
Gespeichert in:
| Veröffentlicht in: | Cornea 1993-03, Vol.12 (2), p.174-180 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 180 |
|---|---|
| container_issue | 2 |
| container_start_page | 174 |
| container_title | Cornea |
| container_volume | 12 |
| creator | Soukiasian, Sarkis H Jakobiec, Frederick A Niles, John L Pavan-Langston, Deborah |
| description | Ophthalmic involvement may be noted in ≤ 58% of Wegenerʼs granulomatosis cases, scleritis being one of the most frequent and potentially devastating manifestations. Cytotoxic immunosuppressive drug therapy is effective treatment for this disorder but potentially highly toxic. Recent uncontrolled and anecdotal reports have suggested a possible therapeutic role for a much less toxic agent, trimethoprim/sulfamethoxazole, in limited Wegenerʼs granulomatosis. We report a patient who had a conjunctival nodule and scleritis. Biopsy of the nodule suggested Wegenerʼs granulomatosis, confirmed serologically with serum anti-neutrophil cytoplasmic antibody (ANCA) testing. Treatment with oral trimethoprim/ sulfamethoxazole was successful. Clinical response was paralleled by normalization of serial anti-neutrophil cytoplasmic antibody titers. This case is the first well-documented ophthalmologic report of limited Wegenerʼs granulomatosis responding to trimethoprim/sulfamethoxazole and adds to the body of literature suggesting a potential role for this drug in selected cases of limited Wegenerʼs granulomatosis. |
| doi_str_mv | 10.1097/00003226-199303000-00015 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_wolte</sourceid><recordid>TN_cdi_pubmed_primary_8500327</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>8500327</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1665-aa47544e0f5c43262ba7e2b4df2eb8163d063107d70977eaf10c9f5ea8b1adab3</originalsourceid><addsrcrecordid>eNp1UctO5DAQtBAIBpZPQPIRDmbtOIkn3KIRj5VGuwcG7XHUSTrE4MSR7WgY_oh_2C_gq_AA122pVSpVdR2qCaGCXwpeqJ88jkySnImikFxGxuKKbI_MRCZzlqpivk9mPFGKSZXyI3Ls_VO0KJUnh-Rwnu3u1Yy8rZzuMXR2jMjuJ9PCJ32BV2uQttbR-9qg00F7Wnpvaw0BG7rRoaNL3esd-YuPOKB7_-fprYNhMraHYL32V_TBI7UtvdM-2BFisLGPWwpDQ8shaDbgFJwdO23oYhsdBnyv60-tss2Wnpe_F-UFXaEPP8hBC8bj6TeekIeb69Xiji3_3P5alEs2ijzPGECqsjRF3mZ1KpM8qUBhUqVNm2A1F7lseC4FV42KPSqEVvC6aDOEeSWggUqekLOv3HGqemzWu2LAbdfflUU9_dI31gR0_tlMG3TrDsGEbv2_x8gPsjSELg</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Trimethoprim-Sulfamethoxazole for Scleritis Associated with Limited Wegenerʼs Granulomatosis: Use of Histopathology and Anti-neutrophil Cytoplasmic Antibody (ANCA) Test</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Soukiasian, Sarkis H ; Jakobiec, Frederick A ; Niles, John L ; Pavan-Langston, Deborah</creator><creatorcontrib>Soukiasian, Sarkis H ; Jakobiec, Frederick A ; Niles, John L ; Pavan-Langston, Deborah</creatorcontrib><description>Ophthalmic involvement may be noted in ≤ 58% of Wegenerʼs granulomatosis cases, scleritis being one of the most frequent and potentially devastating manifestations. Cytotoxic immunosuppressive drug therapy is effective treatment for this disorder but potentially highly toxic. Recent uncontrolled and anecdotal reports have suggested a possible therapeutic role for a much less toxic agent, trimethoprim/sulfamethoxazole, in limited Wegenerʼs granulomatosis. We report a patient who had a conjunctival nodule and scleritis. Biopsy of the nodule suggested Wegenerʼs granulomatosis, confirmed serologically with serum anti-neutrophil cytoplasmic antibody (ANCA) testing. Treatment with oral trimethoprim/ sulfamethoxazole was successful. Clinical response was paralleled by normalization of serial anti-neutrophil cytoplasmic antibody titers. This case is the first well-documented ophthalmologic report of limited Wegenerʼs granulomatosis responding to trimethoprim/sulfamethoxazole and adds to the body of literature suggesting a potential role for this drug in selected cases of limited Wegenerʼs granulomatosis.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/00003226-199303000-00015</identifier><identifier>PMID: 8500327</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Administration, Oral ; Antibodies, Antineutrophil Cytoplasmic ; Autoantibodies - analysis ; Biomarkers ; Conjunctival Diseases - diagnosis ; Conjunctival Diseases - drug therapy ; Conjunctival Diseases - etiology ; Female ; Granulomatosis with Polyangiitis - complications ; Granulomatosis with Polyangiitis - diagnosis ; Granulomatosis with Polyangiitis - drug therapy ; Humans ; Immunoglobulin G - analysis ; Middle Aged ; Scleritis - diagnosis ; Scleritis - drug therapy ; Scleritis - etiology ; Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use</subject><ispartof>Cornea, 1993-03, Vol.12 (2), p.174-180</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8500327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soukiasian, Sarkis H</creatorcontrib><creatorcontrib>Jakobiec, Frederick A</creatorcontrib><creatorcontrib>Niles, John L</creatorcontrib><creatorcontrib>Pavan-Langston, Deborah</creatorcontrib><title>Trimethoprim-Sulfamethoxazole for Scleritis Associated with Limited Wegenerʼs Granulomatosis: Use of Histopathology and Anti-neutrophil Cytoplasmic Antibody (ANCA) Test</title><title>Cornea</title><addtitle>Cornea</addtitle><description>Ophthalmic involvement may be noted in ≤ 58% of Wegenerʼs granulomatosis cases, scleritis being one of the most frequent and potentially devastating manifestations. Cytotoxic immunosuppressive drug therapy is effective treatment for this disorder but potentially highly toxic. Recent uncontrolled and anecdotal reports have suggested a possible therapeutic role for a much less toxic agent, trimethoprim/sulfamethoxazole, in limited Wegenerʼs granulomatosis. We report a patient who had a conjunctival nodule and scleritis. Biopsy of the nodule suggested Wegenerʼs granulomatosis, confirmed serologically with serum anti-neutrophil cytoplasmic antibody (ANCA) testing. Treatment with oral trimethoprim/ sulfamethoxazole was successful. Clinical response was paralleled by normalization of serial anti-neutrophil cytoplasmic antibody titers. This case is the first well-documented ophthalmologic report of limited Wegenerʼs granulomatosis responding to trimethoprim/sulfamethoxazole and adds to the body of literature suggesting a potential role for this drug in selected cases of limited Wegenerʼs granulomatosis.</description><subject>Administration, Oral</subject><subject>Antibodies, Antineutrophil Cytoplasmic</subject><subject>Autoantibodies - analysis</subject><subject>Biomarkers</subject><subject>Conjunctival Diseases - diagnosis</subject><subject>Conjunctival Diseases - drug therapy</subject><subject>Conjunctival Diseases - etiology</subject><subject>Female</subject><subject>Granulomatosis with Polyangiitis - complications</subject><subject>Granulomatosis with Polyangiitis - diagnosis</subject><subject>Granulomatosis with Polyangiitis - drug therapy</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Middle Aged</subject><subject>Scleritis - diagnosis</subject><subject>Scleritis - drug therapy</subject><subject>Scleritis - etiology</subject><subject>Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctO5DAQtBAIBpZPQPIRDmbtOIkn3KIRj5VGuwcG7XHUSTrE4MSR7WgY_oh_2C_gq_AA122pVSpVdR2qCaGCXwpeqJ88jkySnImikFxGxuKKbI_MRCZzlqpivk9mPFGKSZXyI3Ls_VO0KJUnh-Rwnu3u1Yy8rZzuMXR2jMjuJ9PCJ32BV2uQttbR-9qg00F7Wnpvaw0BG7rRoaNL3esd-YuPOKB7_-fprYNhMraHYL32V_TBI7UtvdM-2BFisLGPWwpDQ8shaDbgFJwdO23oYhsdBnyv60-tss2Wnpe_F-UFXaEPP8hBC8bj6TeekIeb69Xiji3_3P5alEs2ijzPGECqsjRF3mZ1KpM8qUBhUqVNm2A1F7lseC4FV42KPSqEVvC6aDOEeSWggUqekLOv3HGqemzWu2LAbdfflUU9_dI31gR0_tlMG3TrDsGEbv2_x8gPsjSELg</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Soukiasian, Sarkis H</creator><creator>Jakobiec, Frederick A</creator><creator>Niles, John L</creator><creator>Pavan-Langston, Deborah</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199303</creationdate><title>Trimethoprim-Sulfamethoxazole for Scleritis Associated with Limited Wegenerʼs Granulomatosis: Use of Histopathology and Anti-neutrophil Cytoplasmic Antibody (ANCA) Test</title><author>Soukiasian, Sarkis H ; Jakobiec, Frederick A ; Niles, John L ; Pavan-Langston, Deborah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1665-aa47544e0f5c43262ba7e2b4df2eb8163d063107d70977eaf10c9f5ea8b1adab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Administration, Oral</topic><topic>Antibodies, Antineutrophil Cytoplasmic</topic><topic>Autoantibodies - analysis</topic><topic>Biomarkers</topic><topic>Conjunctival Diseases - diagnosis</topic><topic>Conjunctival Diseases - drug therapy</topic><topic>Conjunctival Diseases - etiology</topic><topic>Female</topic><topic>Granulomatosis with Polyangiitis - complications</topic><topic>Granulomatosis with Polyangiitis - diagnosis</topic><topic>Granulomatosis with Polyangiitis - drug therapy</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Middle Aged</topic><topic>Scleritis - diagnosis</topic><topic>Scleritis - drug therapy</topic><topic>Scleritis - etiology</topic><topic>Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soukiasian, Sarkis H</creatorcontrib><creatorcontrib>Jakobiec, Frederick A</creatorcontrib><creatorcontrib>Niles, John L</creatorcontrib><creatorcontrib>Pavan-Langston, Deborah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soukiasian, Sarkis H</au><au>Jakobiec, Frederick A</au><au>Niles, John L</au><au>Pavan-Langston, Deborah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trimethoprim-Sulfamethoxazole for Scleritis Associated with Limited Wegenerʼs Granulomatosis: Use of Histopathology and Anti-neutrophil Cytoplasmic Antibody (ANCA) Test</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>1993-03</date><risdate>1993</risdate><volume>12</volume><issue>2</issue><spage>174</spage><epage>180</epage><pages>174-180</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>Ophthalmic involvement may be noted in ≤ 58% of Wegenerʼs granulomatosis cases, scleritis being one of the most frequent and potentially devastating manifestations. Cytotoxic immunosuppressive drug therapy is effective treatment for this disorder but potentially highly toxic. Recent uncontrolled and anecdotal reports have suggested a possible therapeutic role for a much less toxic agent, trimethoprim/sulfamethoxazole, in limited Wegenerʼs granulomatosis. We report a patient who had a conjunctival nodule and scleritis. Biopsy of the nodule suggested Wegenerʼs granulomatosis, confirmed serologically with serum anti-neutrophil cytoplasmic antibody (ANCA) testing. Treatment with oral trimethoprim/ sulfamethoxazole was successful. Clinical response was paralleled by normalization of serial anti-neutrophil cytoplasmic antibody titers. This case is the first well-documented ophthalmologic report of limited Wegenerʼs granulomatosis responding to trimethoprim/sulfamethoxazole and adds to the body of literature suggesting a potential role for this drug in selected cases of limited Wegenerʼs granulomatosis.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>8500327</pmid><doi>10.1097/00003226-199303000-00015</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-3740 |
| ispartof | Cornea, 1993-03, Vol.12 (2), p.174-180 |
| issn | 0277-3740 1536-4798 |
| language | eng |
| recordid | cdi_pubmed_primary_8500327 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Oral Antibodies, Antineutrophil Cytoplasmic Autoantibodies - analysis Biomarkers Conjunctival Diseases - diagnosis Conjunctival Diseases - drug therapy Conjunctival Diseases - etiology Female Granulomatosis with Polyangiitis - complications Granulomatosis with Polyangiitis - diagnosis Granulomatosis with Polyangiitis - drug therapy Humans Immunoglobulin G - analysis Middle Aged Scleritis - diagnosis Scleritis - drug therapy Scleritis - etiology Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use |
| title | Trimethoprim-Sulfamethoxazole for Scleritis Associated with Limited Wegenerʼs Granulomatosis: Use of Histopathology and Anti-neutrophil Cytoplasmic Antibody (ANCA) Test |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T19%3A14%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_wolte&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trimethoprim-Sulfamethoxazole%20for%20Scleritis%20Associated%20with%20Limited%20Wegener%CA%BCs%20Granulomatosis:%20Use%20of%20Histopathology%20and%20Anti-neutrophil%20Cytoplasmic%20Antibody%20(ANCA)%20Test&rft.jtitle=Cornea&rft.au=Soukiasian,%20Sarkis%20H&rft.date=1993-03&rft.volume=12&rft.issue=2&rft.spage=174&rft.epage=180&rft.pages=174-180&rft.issn=0277-3740&rft.eissn=1536-4798&rft_id=info:doi/10.1097/00003226-199303000-00015&rft_dat=%3Cpubmed_wolte%3E8500327%3C/pubmed_wolte%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/8500327&rfr_iscdi=true |