Hydroxocobalamin as a Cyanide Antidote: Safety, Efficacy and Pharmacokinetics in Heavily Smoking Normal Volunteers

Abstract The safety, efficacy and pharmacokinetic parameters of 5 g of hydroxocobalamin given intravenously, alone or in combination with 12.5 g of sodium thiosulfate, were evaluated in healthy adult men who were heavy smokers. Sodium thiosulfate caused nausea, vomiting, and localized burning, muscl...

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Veröffentlicht in:	Clinical toxicology (Philadelphia, Pa.) Pa.), 1993, Vol.31 (2), p.277-294
Hauptverfasser:	Forsyth, John C., Mueller, Paula D., Becker, Charles E., Osterloh, John, Benowitz, Neal L., Rumack, Barry H., Hall, Alan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged antidotes Antidotes - administration & dosage Antidotes - adverse effects Biological and medical sciences Blood Pressure - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Chromatography, High Pressure Liquid cyanides Cyanides - blood Cyanides - poisoning Drug Combinations Heart Rate - drug effects Humans hydroxocobalamin Hydroxocobalamin - administration & dosage Hydroxocobalamin - adverse effects Hydroxocobalamin - pharmacokinetics Infusions, Intravenous Male Medical sciences metabolic clearance rate Metals and various inorganic compounds Middle Aged pharmacokinetics poisoning Safety Smoking - adverse effects thiosulfates Thiosulfates - administration & dosage Thiosulfates - adverse effects Thiosulfates - blood Toxicology
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