Benign Thyroid Adenomas among Persons X-Irradiated in Infancy for Enlarged Thymus Glands
Thyroid adenoma incidence in a cohort of 2657 infants given X-ray treatment for a supposedly enlarged thymus gland, along with 4833 unirradiated siblings, has been ascertained for an average of 37 years since irradiation. Estimated thyroid doses ranged from 0.03 to >8 Gy, with 62% receiving
Gespeichert in:
| Veröffentlicht in: | Radiation research 1993-05, Vol.134 (2), p.217-223 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 223 |
|---|---|
| container_issue | 2 |
| container_start_page | 217 |
| container_title | Radiation research |
| container_volume | 134 |
| creator | Shore, Roy E. Hildreth, Nancy Dvoretsky, Philip Pasternack, Bernard Andresen, Elena |
| description | Thyroid adenoma incidence in a cohort of 2657 infants given X-ray treatment for a supposedly enlarged thymus gland, along with 4833 unirradiated siblings, has been ascertained for an average of 37 years since irradiation. Estimated thyroid doses ranged from 0.03 to >8 Gy, with 62% receiving |
| doi_str_mv | 10.2307/3578462 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmed_primary_8488255</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3578462</jstor_id><sourcerecordid>3578462</sourcerecordid><originalsourceid>FETCH-LOGICAL-j167t-fade404bb9f42d9e168a6879668bd9fa362d0c5139da4bfaacb2f63d69eda7613</originalsourceid><addsrcrecordid>eNo9kE9Lw0AUxBdRaq3iJxD24DW6m032z7GWWgsFPVToLbz07daEZFN200O-vZEWT495PxhmhpBHzl5SwdSryJXOZHpFptwIneQZy67JlDEhEpVrdUvuYqzZqLk0EzLRmdZpnk_J7s366uDp9mcIXYV0jtZ3LUQKbecP9MuG2PlId8k6BMAKeou08nTtHfj9QF0X6NI3EA7jf_RoT5GuGvAY78mNgybah8udke_35XbxkWw-V-vFfJPUXKo-cYB2zFqWxmUpGsulBqmVkVKXaBwImSLb51wYhKx0APsydVKgNBZBSS5m5OnsezyVrcXiGKoWwlBcGo78-czr2HfhH3NW_O1WXHYTv3FgXTw</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Benign Thyroid Adenomas among Persons X-Irradiated in Infancy for Enlarged Thymus Glands</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Shore, Roy E. ; Hildreth, Nancy ; Dvoretsky, Philip ; Pasternack, Bernard ; Andresen, Elena</creator><creatorcontrib>Shore, Roy E. ; Hildreth, Nancy ; Dvoretsky, Philip ; Pasternack, Bernard ; Andresen, Elena</creatorcontrib><description>Thyroid adenoma incidence in a cohort of 2657 infants given X-ray treatment for a supposedly enlarged thymus gland, along with 4833 unirradiated siblings, has been ascertained for an average of 37 years since irradiation. Estimated thyroid doses ranged from 0.03 to >8 Gy, with 62% receiving <0.5 Gy. After excluding 4 adenoma cases with concurrent or previous thyroid cancer, there were 86 cases with pathologically diagnosed thyroid adenomas in the irradiated group and 11 in the sibling controls. The estimated excess relative risk (ERR) was 6.3 per gray (90% CI = 3.7, 11.2). Once the dose group with ≥6 Gy, which was producing downward curvature in the dose-response function, was removed, the curve was compatible with linearity and the ERR was 7.8 per gray. Thyroid adenoma rates were elevated even at low doses: the lowest dose group (<0.25 Gy) showed a significant elevation in risk. The relative risk appeared to be constant over time and was comparable for both sexes. Excess adenoma risk was observed in the irradiated group to the maximum follow-up interval of about 50 years. A number of potential risk factors for thyroid adenoma were examined both as risk factors in their own right and as modifiers of the radiogenic risk. Parity and use of hormones in relation to menopause were significantly associated with thyroid adenoma risk in women, while education, Jewish origin, history of hyperthyroidism or hypothyroidism, and family history of cancer were also adenoma risk factors in both sexes. An examination of interactions between possible risk factors and radiation suggested that women with a history of oral contraceptive use or hysterectomy and persons with a family history of cancer may have greater risk (per unit dose) of radiogenic thyroid adenomas than their counterparts.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3578462</identifier><identifier>PMID: 8488255</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>Adenoma ; Adenoma - epidemiology ; Adenoma - etiology ; Adolescent ; Adult ; Child ; Child, Preschool ; Cohort Studies ; Dose response relationship ; Female ; Follow-Up Studies ; Humans ; Incidence ; Infant ; Irradiation ; Male ; Middle Aged ; Neoplasms, Radiation-Induced - epidemiology ; Nodules ; Predisposing factors ; Radiation dose response relationship ; Radiotherapy ; Radiotherapy - adverse effects ; Retrospective Studies ; Risk Factors ; Siblings ; Surveys and Questionnaires ; Thymus gland ; Thymus Hyperplasia - epidemiology ; Thymus Hyperplasia - radiotherapy ; Thyroid cancer ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - etiology</subject><ispartof>Radiation research, 1993-05, Vol.134 (2), p.217-223</ispartof><rights>Copyright 1993 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3578462$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3578462$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8488255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shore, Roy E.</creatorcontrib><creatorcontrib>Hildreth, Nancy</creatorcontrib><creatorcontrib>Dvoretsky, Philip</creatorcontrib><creatorcontrib>Pasternack, Bernard</creatorcontrib><creatorcontrib>Andresen, Elena</creatorcontrib><title>Benign Thyroid Adenomas among Persons X-Irradiated in Infancy for Enlarged Thymus Glands</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Thyroid adenoma incidence in a cohort of 2657 infants given X-ray treatment for a supposedly enlarged thymus gland, along with 4833 unirradiated siblings, has been ascertained for an average of 37 years since irradiation. Estimated thyroid doses ranged from 0.03 to >8 Gy, with 62% receiving <0.5 Gy. After excluding 4 adenoma cases with concurrent or previous thyroid cancer, there were 86 cases with pathologically diagnosed thyroid adenomas in the irradiated group and 11 in the sibling controls. The estimated excess relative risk (ERR) was 6.3 per gray (90% CI = 3.7, 11.2). Once the dose group with ≥6 Gy, which was producing downward curvature in the dose-response function, was removed, the curve was compatible with linearity and the ERR was 7.8 per gray. Thyroid adenoma rates were elevated even at low doses: the lowest dose group (<0.25 Gy) showed a significant elevation in risk. The relative risk appeared to be constant over time and was comparable for both sexes. Excess adenoma risk was observed in the irradiated group to the maximum follow-up interval of about 50 years. A number of potential risk factors for thyroid adenoma were examined both as risk factors in their own right and as modifiers of the radiogenic risk. Parity and use of hormones in relation to menopause were significantly associated with thyroid adenoma risk in women, while education, Jewish origin, history of hyperthyroidism or hypothyroidism, and family history of cancer were also adenoma risk factors in both sexes. An examination of interactions between possible risk factors and radiation suggested that women with a history of oral contraceptive use or hysterectomy and persons with a family history of cancer may have greater risk (per unit dose) of radiogenic thyroid adenomas than their counterparts.</description><subject>Adenoma</subject><subject>Adenoma - epidemiology</subject><subject>Adenoma - etiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Dose response relationship</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Irradiation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Radiation-Induced - epidemiology</subject><subject>Nodules</subject><subject>Predisposing factors</subject><subject>Radiation dose response relationship</subject><subject>Radiotherapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Siblings</subject><subject>Surveys and Questionnaires</subject><subject>Thymus gland</subject><subject>Thymus Hyperplasia - epidemiology</subject><subject>Thymus Hyperplasia - radiotherapy</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - etiology</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9Lw0AUxBdRaq3iJxD24DW6m032z7GWWgsFPVToLbz07daEZFN200O-vZEWT495PxhmhpBHzl5SwdSryJXOZHpFptwIneQZy67JlDEhEpVrdUvuYqzZqLk0EzLRmdZpnk_J7s366uDp9mcIXYV0jtZ3LUQKbecP9MuG2PlId8k6BMAKeou08nTtHfj9QF0X6NI3EA7jf_RoT5GuGvAY78mNgybah8udke_35XbxkWw-V-vFfJPUXKo-cYB2zFqWxmUpGsulBqmVkVKXaBwImSLb51wYhKx0APsydVKgNBZBSS5m5OnsezyVrcXiGKoWwlBcGo78-czr2HfhH3NW_O1WXHYTv3FgXTw</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Shore, Roy E.</creator><creator>Hildreth, Nancy</creator><creator>Dvoretsky, Philip</creator><creator>Pasternack, Bernard</creator><creator>Andresen, Elena</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19930501</creationdate><title>Benign Thyroid Adenomas among Persons X-Irradiated in Infancy for Enlarged Thymus Glands</title><author>Shore, Roy E. ; Hildreth, Nancy ; Dvoretsky, Philip ; Pasternack, Bernard ; Andresen, Elena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j167t-fade404bb9f42d9e168a6879668bd9fa362d0c5139da4bfaacb2f63d69eda7613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenoma</topic><topic>Adenoma - epidemiology</topic><topic>Adenoma - etiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Dose response relationship</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Irradiation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Radiation-Induced - epidemiology</topic><topic>Nodules</topic><topic>Predisposing factors</topic><topic>Radiation dose response relationship</topic><topic>Radiotherapy</topic><topic>Radiotherapy - adverse effects</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Siblings</topic><topic>Surveys and Questionnaires</topic><topic>Thymus gland</topic><topic>Thymus Hyperplasia - epidemiology</topic><topic>Thymus Hyperplasia - radiotherapy</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shore, Roy E.</creatorcontrib><creatorcontrib>Hildreth, Nancy</creatorcontrib><creatorcontrib>Dvoretsky, Philip</creatorcontrib><creatorcontrib>Pasternack, Bernard</creatorcontrib><creatorcontrib>Andresen, Elena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shore, Roy E.</au><au>Hildreth, Nancy</au><au>Dvoretsky, Philip</au><au>Pasternack, Bernard</au><au>Andresen, Elena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benign Thyroid Adenomas among Persons X-Irradiated in Infancy for Enlarged Thymus Glands</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>134</volume><issue>2</issue><spage>217</spage><epage>223</epage><pages>217-223</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>Thyroid adenoma incidence in a cohort of 2657 infants given X-ray treatment for a supposedly enlarged thymus gland, along with 4833 unirradiated siblings, has been ascertained for an average of 37 years since irradiation. Estimated thyroid doses ranged from 0.03 to >8 Gy, with 62% receiving <0.5 Gy. After excluding 4 adenoma cases with concurrent or previous thyroid cancer, there were 86 cases with pathologically diagnosed thyroid adenomas in the irradiated group and 11 in the sibling controls. The estimated excess relative risk (ERR) was 6.3 per gray (90% CI = 3.7, 11.2). Once the dose group with ≥6 Gy, which was producing downward curvature in the dose-response function, was removed, the curve was compatible with linearity and the ERR was 7.8 per gray. Thyroid adenoma rates were elevated even at low doses: the lowest dose group (<0.25 Gy) showed a significant elevation in risk. The relative risk appeared to be constant over time and was comparable for both sexes. Excess adenoma risk was observed in the irradiated group to the maximum follow-up interval of about 50 years. A number of potential risk factors for thyroid adenoma were examined both as risk factors in their own right and as modifiers of the radiogenic risk. Parity and use of hormones in relation to menopause were significantly associated with thyroid adenoma risk in women, while education, Jewish origin, history of hyperthyroidism or hypothyroidism, and family history of cancer were also adenoma risk factors in both sexes. An examination of interactions between possible risk factors and radiation suggested that women with a history of oral contraceptive use or hysterectomy and persons with a family history of cancer may have greater risk (per unit dose) of radiogenic thyroid adenomas than their counterparts.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>8488255</pmid><doi>10.2307/3578462</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 1993-05, Vol.134 (2), p.217-223 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_pubmed_primary_8488255 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adenoma Adenoma - epidemiology Adenoma - etiology Adolescent Adult Child Child, Preschool Cohort Studies Dose response relationship Female Follow-Up Studies Humans Incidence Infant Irradiation Male Middle Aged Neoplasms, Radiation-Induced - epidemiology Nodules Predisposing factors Radiation dose response relationship Radiotherapy Radiotherapy - adverse effects Retrospective Studies Risk Factors Siblings Surveys and Questionnaires Thymus gland Thymus Hyperplasia - epidemiology Thymus Hyperplasia - radiotherapy Thyroid cancer Thyroid Neoplasms - epidemiology Thyroid Neoplasms - etiology |
| title | Benign Thyroid Adenomas among Persons X-Irradiated in Infancy for Enlarged Thymus Glands |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T11%3A31%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Benign%20Thyroid%20Adenomas%20among%20Persons%20X-Irradiated%20in%20Infancy%20for%20Enlarged%20Thymus%20Glands&rft.jtitle=Radiation%20research&rft.au=Shore,%20Roy%20E.&rft.date=1993-05-01&rft.volume=134&rft.issue=2&rft.spage=217&rft.epage=223&rft.pages=217-223&rft.issn=0033-7587&rft.eissn=1938-5404&rft_id=info:doi/10.2307/3578462&rft_dat=%3Cjstor_pubme%3E3578462%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/8488255&rft_jstor_id=3578462&rfr_iscdi=true |