A Mutation within Intron 3 of the Pax-3 Gene Produces Aberrantly Spliced mRNA Transcripts in the Splotch (Sp) Mouse Mutant

The splotch (Sp) mouse mutant displays defects in neural tube closure in the form of exencephaly and spina bifida. Recently, mutations in the Pax-3 gene have been described in the radiation-induced Sprand Sp2Halleles. This led us to examine the integrity of the Pax-3 gene and its cellular mRNA trans...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-01, Vol.90 (2), p.532-536
Hauptverfasser:	Epstein, Douglas J., Vogan, Kyle J., Trasler, Daphne G., Gros, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cloning, Molecular Complementary DNA DNA Embryos Exons Genes Genetic mutation Genetics Genomics Introns Introns - genetics Malformations of the nervous system Medical sciences Messenger RNA Mice Mice, Mutant Strains - genetics Molecular Sequence Data Mutation Neurology Polymerase Chain Reaction Ribonucleic acid RNA RNA, Messenger - biosynthesis RNA, Messenger - genetics Rodents Sequence Analysis, DNA Splicing
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