Monoclonal Anti-Idiotypic Antibodies as Functional Internal Images of Enzyme Active Sites: Production of a Catalytic Antibody with a Cholinesterase Activity

Monoclonal antibody 9A8 was selected by immunizing mice with AE-2, a monoclonal antibody directed against the active site of acetylcholinesterase. In accordance with the idiotypic network theory, monoclonal anti-idiotypic antibody 9A8 displayed internal-image properties of the original immunogen, th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-10, Vol.90 (19), p.8876-8880
Hauptverfasser:	IZADYAR, L, FRIBOULET, A, REMY, M. H, ROSETO, A, THOMAS, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Active sites Animals Anti idiotypic antibodies Antibodies Antibodies, Anti-Idiotypic - isolation & purification Antibodies, Anti-Idiotypic - metabolism Antibodies, Monoclonal - isolation & purification Antibodies, Monoclonal - metabolism Antigens Binding Sites Biochemistry Biological and medical sciences Biotechnology Butyrylcholinesterase - metabolism Catalysis Catalytic activity Cholinesterase Inhibitors - pharmacology Cholinesterases - metabolism Clone Cells Enzyme engineering Enzymes Esters Fundamental and applied biological sciences. Psychology Hybridomas Hydrolysis Immune Sera - metabolism Immunity (Disease) Immunoglobulin Fab Fragments - isolation & purification Immunoglobulin Fab Fragments - metabolism Kinetics Medical research Methods. Procedures. Technologies Mice Miscellaneous Substrate Specificity
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