Induction of RAR-beta 2 gene expression in embryos and RAR-beta 2 transactivation by the synthetic retinoid Ro 13-6307 correlates with its high teratogenic potency

Vitamin A (retinol), its metabolite all-trans retinoic acid (RA), and many synthetic analogs (retinoids) express variable potencies as teratogens. Although biological activities of retinoids are mediated by nuclear RA receptors (RARs) and retinoid X receptors (RXRs), it is not known if any of these...

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Veröffentlicht in:	Toxicology and applied pharmacology 1993-09, Vol.122 (1), p.159
Hauptverfasser:	Soprano, D R, Tairis, N, Gyda, 3rd, M, Harnish, D C, Jiang, H, Soprano, K J, Kochhar, D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Embryo, Mammalian - drug effects Embryo, Mammalian - metabolism Fatty Acids, Unsaturated - toxicity Female Gene Expression Regulation - drug effects Mice Pregnancy Receptors, Retinoic Acid RNA, Messenger - genetics RNA, Messenger - metabolism Stereoisomerism Teratogens - toxicity Transcription, Genetic - drug effects Transcriptional Activation - drug effects Tretinoin
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