The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis
To investigate the role of TNF-alpha in endotoxin-induced uveitis (EIU) in mice. To neutralize TNF-alpha activity, mice were pretreated with either repeated injections of this cytokine or a single injection of antibody against it. The mice were then injected intraperitoneally with 500 micrograms end...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1993-09, Vol.34 (10), p.2911-2917 |
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| creator | Kasner, L Chan, CC Whitcup, SM Gery, I |
| description | To investigate the role of TNF-alpha in endotoxin-induced uveitis (EIU) in mice.
To neutralize TNF-alpha activity, mice were pretreated with either repeated injections of this cytokine or a single injection of antibody against it. The mice were then injected intraperitoneally with 500 micrograms endotoxin, to induce lethal septic shock, or into the footpad with 200 micrograms to induce EIU.
Although both pretreatments conferred protection against the systemic toxic effects of LPS, TNF-resistant mice and mice treated with anti-TNF-alpha antibody demonstrated an exacerbation of EIU when compared to control animals.
Unlike its apparent participation in the systemic effect of endotoxin, TNF-alpha is not directly involved in the pathogenesis of EIU and may even protect against the inflammatory processes of this disease. |
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To neutralize TNF-alpha activity, mice were pretreated with either repeated injections of this cytokine or a single injection of antibody against it. The mice were then injected intraperitoneally with 500 micrograms endotoxin, to induce lethal septic shock, or into the footpad with 200 micrograms to induce EIU.
Although both pretreatments conferred protection against the systemic toxic effects of LPS, TNF-resistant mice and mice treated with anti-TNF-alpha antibody demonstrated an exacerbation of EIU when compared to control animals.
Unlike its apparent participation in the systemic effect of endotoxin, TNF-alpha is not directly involved in the pathogenesis of EIU and may even protect against the inflammatory processes of this disease.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 8360023</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Acute Disease ; Animals ; Bacterial Toxins ; Biological and medical sciences ; Disease Models, Animal ; Endotoxins ; Female ; Medical sciences ; Mice ; Mice, Inbred C3H ; Ophthalmology ; Recombinant Proteins - immunology ; Salmonella typhimurium ; Tumor Necrosis Factor-alpha - immunology ; Uvea diseases ; Uveitis, Anterior - immunology ; Uveitis, Anterior - pathology ; Uveitis, Anterior - prevention & control</subject><ispartof>Investigative ophthalmology & visual science, 1993-09, Vol.34 (10), p.2911-2917</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4901449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8360023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasner, L</creatorcontrib><creatorcontrib>Chan, CC</creatorcontrib><creatorcontrib>Whitcup, SM</creatorcontrib><creatorcontrib>Gery, I</creatorcontrib><title>The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To investigate the role of TNF-alpha in endotoxin-induced uveitis (EIU) in mice.
To neutralize TNF-alpha activity, mice were pretreated with either repeated injections of this cytokine or a single injection of antibody against it. The mice were then injected intraperitoneally with 500 micrograms endotoxin, to induce lethal septic shock, or into the footpad with 200 micrograms to induce EIU.
Although both pretreatments conferred protection against the systemic toxic effects of LPS, TNF-resistant mice and mice treated with anti-TNF-alpha antibody demonstrated an exacerbation of EIU when compared to control animals.
Unlike its apparent participation in the systemic effect of endotoxin, TNF-alpha is not directly involved in the pathogenesis of EIU and may even protect against the inflammatory processes of this disease.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Bacterial Toxins</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Endotoxins</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Ophthalmology</subject><subject>Recombinant Proteins - immunology</subject><subject>Salmonella typhimurium</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Uvea diseases</subject><subject>Uveitis, Anterior - immunology</subject><subject>Uveitis, Anterior - pathology</subject><subject>Uveitis, Anterior - prevention & control</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1Lw0AUXESptfoThD0I6iGwX9lujlKsCkUv9Wp43X0xK_kimxj7711s8V3eDDMMzJyQOU9TkaRLI0_JnHGlE6aYOicXIXwxJjgXbEZmRupI5Jx8bEukHfTg2h9voaJYFGgH2hZ0GOu2pw3avg0-0ALsEDlUXQn0bvu6Tv7gPfUNxca1QwxoEt-40aKj4zf6wYdLclZAFfDq-Bfkff24XT0nm7enl9XDJimFXg4JKOSFdQKY1pg5ZYQU0jJmMusA0ThhNe6ctppnEQIYjGeXLDVGCGfkglwfcrtxV6PLu97X0O_zY8-o3xx1CLFl0UNjffi3qSwupbJouz3YSv9ZTr7HPNRQVTGU59M0SZVzlouMc_kLqY5q9w</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Kasner, L</creator><creator>Chan, CC</creator><creator>Whitcup, SM</creator><creator>Gery, I</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19930901</creationdate><title>The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis</title><author>Kasner, L ; Chan, CC ; Whitcup, SM ; Gery, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-a4e1fcd2a066e9d482323c0089cdaee8d2c6ebd6c6192c6aa8eeeec7058822d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Bacterial Toxins</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Endotoxins</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Ophthalmology</topic><topic>Recombinant Proteins - immunology</topic><topic>Salmonella typhimurium</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Uvea diseases</topic><topic>Uveitis, Anterior - immunology</topic><topic>Uveitis, Anterior - pathology</topic><topic>Uveitis, Anterior - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasner, L</creatorcontrib><creatorcontrib>Chan, CC</creatorcontrib><creatorcontrib>Whitcup, SM</creatorcontrib><creatorcontrib>Gery, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasner, L</au><au>Chan, CC</au><au>Whitcup, SM</au><au>Gery, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>34</volume><issue>10</issue><spage>2911</spage><epage>2917</epage><pages>2911-2917</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To investigate the role of TNF-alpha in endotoxin-induced uveitis (EIU) in mice.
To neutralize TNF-alpha activity, mice were pretreated with either repeated injections of this cytokine or a single injection of antibody against it. The mice were then injected intraperitoneally with 500 micrograms endotoxin, to induce lethal septic shock, or into the footpad with 200 micrograms to induce EIU.
Although both pretreatments conferred protection against the systemic toxic effects of LPS, TNF-resistant mice and mice treated with anti-TNF-alpha antibody demonstrated an exacerbation of EIU when compared to control animals.
Unlike its apparent participation in the systemic effect of endotoxin, TNF-alpha is not directly involved in the pathogenesis of EIU and may even protect against the inflammatory processes of this disease.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>8360023</pmid><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-0404 |
| ispartof | Investigative ophthalmology & visual science, 1993-09, Vol.34 (10), p.2911-2917 |
| issn | 0146-0404 1552-5783 |
| language | eng |
| recordid | cdi_pubmed_primary_8360023 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Disease Animals Bacterial Toxins Biological and medical sciences Disease Models, Animal Endotoxins Female Medical sciences Mice Mice, Inbred C3H Ophthalmology Recombinant Proteins - immunology Salmonella typhimurium Tumor Necrosis Factor-alpha - immunology Uvea diseases Uveitis, Anterior - immunology Uveitis, Anterior - pathology Uveitis, Anterior - prevention & control |
| title | The paradoxical effect of tumor necrosis factor alpha (TNF-alpha) in endotoxin-induced uveitis |
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