Tityustoxin-K alpha, a structurally novel and highly potent K+ channel peptide toxin, interacts with the alpha-dendrotoxin binding site on the cloned Kv1.2 K+ channel

The interaction between two nonhomologous K+ channel toxins, Tityus serrulatus (scorpion) toxin tityustoxin-K alpha (TsTX-K alpha) and Dendroaspis angusticeps (snake) toxin dendrotoxin (alpha-DTX), was investigated on K+ currents in B82 fibroblast cells transformed to express the Kv1.2 K+ channel. A...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 1993-08, Vol.44 (2), p.430
Hauptverfasser:	Werkman, T R, Gustafson, T A, Rogowski, R S, Blaustein, M P, Rogawski, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites Binding, Competitive Cell Line Dose-Response Relationship, Drug Elapid Venoms - metabolism Elapid Venoms - pharmacology Electrophysiology Molecular Sequence Data Neurotoxins - metabolism Neurotoxins - pharmacology Potassium Channels - drug effects Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Scorpion Venoms - metabolism Scorpion Venoms - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!