Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes

Analysis of [3H]phorbol-12,13-dibutyrate (PDBu) binding was performed with protein kinase C (PKC)-alpha, -beta 1, -gamma, -delta, -epsilon, -eta, and -zeta produced in Sf9 insect cells using the baculovirus expression system. With the exception of PKC-zeta, all of the PKC isozymes bound [3H]PDBu wit...

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Veröffentlicht in:	Molecular pharmacology 1993-08, Vol.44 (2), p.298-307
Hauptverfasser:	Kazanietz, M G, Areces, L B, Bahador, A, Mischak, H, Goodnight, J, Mushinski, J F, Blumberg, P M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Baculoviridae - genetics Base Sequence Biological and medical sciences Calcium - metabolism Cell Line Enzyme Activation Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Isoenzymes - metabolism Molecular Sequence Data Moths Phorbol 12,13-Dibutyrate - metabolism Protein Kinase C - chemistry Protein Kinase C - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Structure-Activity Relationship Substrate Specificity Transferases
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