Myocardial Substrate Utilization and Left Ventricular Function in Adriamycin Cardiomyopathy

We evaluated alterations of substrate utilization in a rat model of adriamycin cardiomyopathy with deteriorating left ventricular function. Rats were treated with adriamycin (2 mg/kg), once a week for 6, 8, 9 and 10 wk. Fluorine-18-F-deoxyglucose (18F-FDG) and 125I-beta-methyl-branched fatty acid (1...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1993-09, Vol.34 (9), p.1529
Hauptverfasser:	Wakasugi, Shigetoshi, Fischman, Alan J, Babich, John W, Callahan, Ronald J, Elmaleh, David R, Wilkinson, Robert, Strauss, H. William
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Deoxyglucose - analogs & derivatives Doxorubicin - adverse effects Fatty Acids Fluorine Radioisotopes Fluorodeoxyglucose F18 Gated Blood-Pool Imaging Heart - diagnostic imaging Heart Failure - chemically induced Heart Failure - diagnostic imaging Iodine Radioisotopes Iodobenzenes Male Myocardium - metabolism Rats Rats, Wistar Technetium Tc 99m Sestamibi Ventricular Function, Left - drug effects
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