Characterization of a Saporin Mitotoxin Specifically Cytotoxic to Cells Bearing the Granulocyte-Macrophage Colony-Stimulating Factor Receptor

Abstract When granulocyte-macrophage colony-stimulating factor (GM-CSF) is chemically conjugated to the ribosome-inactivating protein saporin, the resulting protein conjugate is highly toxic for cells expressing the GM-CSF receptor. Structural and Western blot analyses of the purified conjugate esta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Growth factors (Chur, Switzerland) Switzerland), 1993, Vol.9 (1), p.31-39
Hauptverfasser:	Lappi, Douglas A., Martineau, Darlene, Sarmientos, Paolo, Garofano, Luisa, Aranda, Augustin Perez, Miyajima, Atsushi, Kitamura, Toshio, Baird, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonist Cell Death - drug effects Cell Line Cross-Linking Reagents - administration & dosage Cross-Linking Reagents - isolation & purification granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology immunotoxin Immunotoxins Mice Mitogens - administration & dosage mitotoxin N-Glycosyl Hydrolases Plant Proteins - administration & dosage Plant Proteins - toxicity Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - drug effects Ribosome Inactivating Proteins, Type 1 Ribosomes - drug effects saporin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!