Gonadal function in prepubertal boys following treatment for Hodgkin's disease
Gonadal functions were evaluated in 26 male patients with Hodgkin's disease (HD), who were in continuous unmaintained remission following combination chemotherapy consisting of COPP/MOPP. These patients had received chemotherapy during the prepubertal phase. The median duration after terminatio...
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| Veröffentlicht in: | The American journal of pediatric hematology/oncology 1993-08, Vol.15 (3), p.306-310 |
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| container_title | The American journal of pediatric hematology/oncology |
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| creator | DHABBAR, B. N MALHOTRA, H JOSEPH, R GARDE, S SUNAINA BHASIN SHETH, A ADVANI, S. H |
| description | Gonadal functions were evaluated in 26 male patients with Hodgkin's disease (HD), who were in continuous unmaintained remission following combination chemotherapy consisting of COPP/MOPP.
These patients had received chemotherapy during the prepubertal phase. The median duration after termination of chemotherapy was 72 months.
Semen analysis of 18 patients showed azoospermia. Hormonal analysis showed elevated mean levels follicle-stimulating hormone (FSH) and inhibin as compared to age-matched controls, whereas luteinizing hormone levels were only marginally elevated.
These results suggest that COPP/MOPP causes severe damage to germinal epithelium even when given during prepubertal age. Sertoli cells, which are responsible for secretion of inhibin, are resistant to these cytotoxic agents. Our data emphasize the lack of gross dysfunction of Leydig cells. It is possible that an alternative chemotherapy protocol (ABVD) may be used in young patients to minimize the gonadal damage. |
| format | Article |
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These patients had received chemotherapy during the prepubertal phase. The median duration after termination of chemotherapy was 72 months.
Semen analysis of 18 patients showed azoospermia. Hormonal analysis showed elevated mean levels follicle-stimulating hormone (FSH) and inhibin as compared to age-matched controls, whereas luteinizing hormone levels were only marginally elevated.
These results suggest that COPP/MOPP causes severe damage to germinal epithelium even when given during prepubertal age. Sertoli cells, which are responsible for secretion of inhibin, are resistant to these cytotoxic agents. Our data emphasize the lack of gross dysfunction of Leydig cells. It is possible that an alternative chemotherapy protocol (ABVD) may be used in young patients to minimize the gonadal damage.</description><identifier>ISSN: 0192-8562</identifier><identifier>EISSN: 2331-4532</identifier><identifier>PMID: 8328644</identifier><identifier>CODEN: APHODH</identifier><language>eng</language><publisher>New York, NY: Raven Press</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Biological and medical sciences ; Child ; Child, Preschool ; Cyclophosphamide - adverse effects ; Follicle Stimulating Hormone - blood ; Hematologic and hematopoietic diseases ; Hodgkin Disease - drug therapy ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Luteinizing Hormone - blood ; Male ; Mechlorethamine - adverse effects ; Medical sciences ; Oligospermia - chemically induced ; Prednisone - adverse effects ; Procarbazine - adverse effects ; Puberty - drug effects ; Testis - drug effects ; Testis - pathology ; Vincristine - adverse effects</subject><ispartof>The American journal of pediatric hematology/oncology, 1993-08, Vol.15 (3), p.306-310</ispartof><rights>1993 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4870540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8328644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DHABBAR, B. N</creatorcontrib><creatorcontrib>MALHOTRA, H</creatorcontrib><creatorcontrib>JOSEPH, R</creatorcontrib><creatorcontrib>GARDE, S</creatorcontrib><creatorcontrib>SUNAINA BHASIN</creatorcontrib><creatorcontrib>SHETH, A</creatorcontrib><creatorcontrib>ADVANI, S. H</creatorcontrib><title>Gonadal function in prepubertal boys following treatment for Hodgkin's disease</title><title>The American journal of pediatric hematology/oncology</title><addtitle>Am J Pediatr Hematol Oncol</addtitle><description>Gonadal functions were evaluated in 26 male patients with Hodgkin's disease (HD), who were in continuous unmaintained remission following combination chemotherapy consisting of COPP/MOPP.
These patients had received chemotherapy during the prepubertal phase. The median duration after termination of chemotherapy was 72 months.
Semen analysis of 18 patients showed azoospermia. Hormonal analysis showed elevated mean levels follicle-stimulating hormone (FSH) and inhibin as compared to age-matched controls, whereas luteinizing hormone levels were only marginally elevated.
These results suggest that COPP/MOPP causes severe damage to germinal epithelium even when given during prepubertal age. Sertoli cells, which are responsible for secretion of inhibin, are resistant to these cytotoxic agents. Our data emphasize the lack of gross dysfunction of Leydig cells. It is possible that an alternative chemotherapy protocol (ABVD) may be used in young patients to minimize the gonadal damage.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Mechlorethamine - adverse effects</subject><subject>Medical sciences</subject><subject>Oligospermia - chemically induced</subject><subject>Prednisone - adverse effects</subject><subject>Procarbazine - adverse effects</subject><subject>Puberty - drug effects</subject><subject>Testis - drug effects</subject><subject>Testis - pathology</subject><subject>Vincristine - adverse effects</subject><issn>0192-8562</issn><issn>2331-4532</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j01LxDAYhIMoa139CUIOgqdCPtv0KIvuCote9Ly8Sd4u0TYtSRfZf2_B4mngmWGYuSCFkJKXSktxSQrGG1EaXYlrcpPzF2NMatWsyMpIYSqlCvK2HSJ46Gh7im4KQ6Qh0jHheLKYppnb4ZxpO3Td8BPikU4JYeoxTjNLdDf443eIj5n6kBEy3pKrFrqMd4uuyefL88dmV-7ft6-bp305Cqmn0moFsoHKGwHWekAH3vHWGu9qlB5ra2pX84a5VjvjtOFYWcmNtrXgDI1ck_u_3nlnj_4wptBDOh-WX7P_sPiQHXRtguhC_o8pUzOtmPwFxhNZFw</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>DHABBAR, B. 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Myelofibrosis</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Mechlorethamine - adverse effects</topic><topic>Medical sciences</topic><topic>Oligospermia - chemically induced</topic><topic>Prednisone - adverse effects</topic><topic>Procarbazine - adverse effects</topic><topic>Puberty - drug effects</topic><topic>Testis - drug effects</topic><topic>Testis - pathology</topic><topic>Vincristine - adverse effects</topic><toplevel>online_resources</toplevel><creatorcontrib>DHABBAR, B. N</creatorcontrib><creatorcontrib>MALHOTRA, H</creatorcontrib><creatorcontrib>JOSEPH, R</creatorcontrib><creatorcontrib>GARDE, S</creatorcontrib><creatorcontrib>SUNAINA BHASIN</creatorcontrib><creatorcontrib>SHETH, A</creatorcontrib><creatorcontrib>ADVANI, S. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The American journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DHABBAR, B. N</au><au>MALHOTRA, H</au><au>JOSEPH, R</au><au>GARDE, S</au><au>SUNAINA BHASIN</au><au>SHETH, A</au><au>ADVANI, S. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gonadal function in prepubertal boys following treatment for Hodgkin's disease</atitle><jtitle>The American journal of pediatric hematology/oncology</jtitle><addtitle>Am J Pediatr Hematol Oncol</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>15</volume><issue>3</issue><spage>306</spage><epage>310</epage><pages>306-310</pages><issn>0192-8562</issn><eissn>2331-4532</eissn><coden>APHODH</coden><abstract>Gonadal functions were evaluated in 26 male patients with Hodgkin's disease (HD), who were in continuous unmaintained remission following combination chemotherapy consisting of COPP/MOPP.
These patients had received chemotherapy during the prepubertal phase. The median duration after termination of chemotherapy was 72 months.
Semen analysis of 18 patients showed azoospermia. Hormonal analysis showed elevated mean levels follicle-stimulating hormone (FSH) and inhibin as compared to age-matched controls, whereas luteinizing hormone levels were only marginally elevated.
These results suggest that COPP/MOPP causes severe damage to germinal epithelium even when given during prepubertal age. Sertoli cells, which are responsible for secretion of inhibin, are resistant to these cytotoxic agents. Our data emphasize the lack of gross dysfunction of Leydig cells. It is possible that an alternative chemotherapy protocol (ABVD) may be used in young patients to minimize the gonadal damage.</abstract><cop>New York, NY</cop><pub>Raven Press</pub><pmid>8328644</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0192-8562 |
| ispartof | The American journal of pediatric hematology/oncology, 1993-08, Vol.15 (3), p.306-310 |
| issn | 0192-8562 2331-4532 |
| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Child Child, Preschool Cyclophosphamide - adverse effects Follicle Stimulating Hormone - blood Hematologic and hematopoietic diseases Hodgkin Disease - drug therapy Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Luteinizing Hormone - blood Male Mechlorethamine - adverse effects Medical sciences Oligospermia - chemically induced Prednisone - adverse effects Procarbazine - adverse effects Puberty - drug effects Testis - drug effects Testis - pathology Vincristine - adverse effects |
| title | Gonadal function in prepubertal boys following treatment for Hodgkin's disease |
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