c-fos Expression in Gracilothalamic Tract Neurons after Electrical Stimulation of the Injured Sciatic Nerve in the Adult Rat
The number of c-fos protein-like immunoreactive (Fos-LI) cells in the gracile nucleus was determined after electrical stimulation at Aα/Aβ-fiber strength of the normal and of the previously injured sciatic nerve in adult rats. No Fos-LI cells were seen after electrical stimulation of the noninjured...
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| Veröffentlicht in: | Somatosensory & motor research 1993, Vol.10 (4), p.475-483 |
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| creator | Persson, Jonas K. E. Hongpaisan, Jarin Molander, Carl |
| description | The number of c-fos protein-like immunoreactive (Fos-LI) cells in the gracile nucleus was determined after electrical stimulation at Aα/Aβ-fiber strength of the normal and of the previously injured sciatic nerve in adult rats. No Fos-LI cells were seen after electrical stimulation of the noninjured sciatic nerve, or after sciatic nerve injury without electrical stimulation. However, stimulation 21 days after sciatic nerve transection resulted in numerous Fos-LI cells in the ipsilateral gracile nucleus. Combined Fos immunocytochemistry and retrograde labeling from the thalamus showed that the majority (76%; range = 70-80%) of the cells in the gracile nucleus that expressed Fos-LI after nerve injury projected to the thalamus. The results indicate that morphological, biochemical, and physiological alterations in primary sensory central endings and second-order neurons, which have earlier been demonstrated in the dorsal column nuclei after peripheral nerve injury, are accompanied by changes in the c-fos gene activation pattern after stimulation of the injured sciatic nerve. A substantial number of the c-fos-expressing neurons project to the thalamus. |
| doi_str_mv | 10.3109/08990229309028852 |
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E. ; Hongpaisan, Jarin ; Molander, Carl</creator><creatorcontrib>Persson, Jonas K. E. ; Hongpaisan, Jarin ; Molander, Carl</creatorcontrib><description>The number of c-fos protein-like immunoreactive (Fos-LI) cells in the gracile nucleus was determined after electrical stimulation at Aα/Aβ-fiber strength of the normal and of the previously injured sciatic nerve in adult rats. No Fos-LI cells were seen after electrical stimulation of the noninjured sciatic nerve, or after sciatic nerve injury without electrical stimulation. However, stimulation 21 days after sciatic nerve transection resulted in numerous Fos-LI cells in the ipsilateral gracile nucleus. Combined Fos immunocytochemistry and retrograde labeling from the thalamus showed that the majority (76%; range = 70-80%) of the cells in the gracile nucleus that expressed Fos-LI after nerve injury projected to the thalamus. The results indicate that morphological, biochemical, and physiological alterations in primary sensory central endings and second-order neurons, which have earlier been demonstrated in the dorsal column nuclei after peripheral nerve injury, are accompanied by changes in the c-fos gene activation pattern after stimulation of the injured sciatic nerve. A substantial number of the c-fos-expressing neurons project to the thalamus.</description><identifier>ISSN: 0736-7224</identifier><identifier>ISSN: 0899-0220</identifier><identifier>EISSN: 1369-1651</identifier><identifier>DOI: 10.3109/08990229309028852</identifier><identifier>PMID: 8310784</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; dorsal column ; Electric Stimulation ; Female ; Fluorescent Antibody Technique ; Functional Laterality - physiology ; Gene Expression Regulation - physiology ; immediate early gene ; Medulla Oblongata - physiology ; Nerve Degeneration - genetics ; Nerve Degeneration - physiology ; Nerve Fibers, Myelinated - physiology ; nerve injury ; nerve stimulation ; Neuronal Plasticity - genetics ; Neuronal Plasticity - physiology ; plasticity ; primary sensory neuron ; Proto-Oncogene Proteins c-fos - genetics ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve - injuries ; Sciatic Nerve - physiology ; Synaptic Transmission - genetics ; Synaptic Transmission - physiology ; Thalamic Nuclei - physiology ; Transcriptional Activation</subject><ispartof>Somatosensory & motor research, 1993, Vol.10 (4), p.475-483</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-498a6caf0b3cc156c566a9771837cc6d0686c65fbf68ed408ea9e5ce5cb8fe843</citedby><cites>FETCH-LOGICAL-c432t-498a6caf0b3cc156c566a9771837cc6d0686c65fbf68ed408ea9e5ce5cb8fe843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08990229309028852$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08990229309028852$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8310784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Persson, Jonas K. E.</creatorcontrib><creatorcontrib>Hongpaisan, Jarin</creatorcontrib><creatorcontrib>Molander, Carl</creatorcontrib><title>c-fos Expression in Gracilothalamic Tract Neurons after Electrical Stimulation of the Injured Sciatic Nerve in the Adult Rat</title><title>Somatosensory & motor research</title><addtitle>Somatosens Mot Res</addtitle><description>The number of c-fos protein-like immunoreactive (Fos-LI) cells in the gracile nucleus was determined after electrical stimulation at Aα/Aβ-fiber strength of the normal and of the previously injured sciatic nerve in adult rats. No Fos-LI cells were seen after electrical stimulation of the noninjured sciatic nerve, or after sciatic nerve injury without electrical stimulation. However, stimulation 21 days after sciatic nerve transection resulted in numerous Fos-LI cells in the ipsilateral gracile nucleus. Combined Fos immunocytochemistry and retrograde labeling from the thalamus showed that the majority (76%; range = 70-80%) of the cells in the gracile nucleus that expressed Fos-LI after nerve injury projected to the thalamus. The results indicate that morphological, biochemical, and physiological alterations in primary sensory central endings and second-order neurons, which have earlier been demonstrated in the dorsal column nuclei after peripheral nerve injury, are accompanied by changes in the c-fos gene activation pattern after stimulation of the injured sciatic nerve. A substantial number of the c-fos-expressing neurons project to the thalamus.</description><subject>Animals</subject><subject>dorsal column</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Functional Laterality - physiology</subject><subject>Gene Expression Regulation - physiology</subject><subject>immediate early gene</subject><subject>Medulla Oblongata - physiology</subject><subject>Nerve Degeneration - genetics</subject><subject>Nerve Degeneration - physiology</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>nerve injury</subject><subject>nerve stimulation</subject><subject>Neuronal Plasticity - genetics</subject><subject>Neuronal Plasticity - physiology</subject><subject>plasticity</subject><subject>primary sensory neuron</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sciatic Nerve - injuries</subject><subject>Sciatic Nerve - physiology</subject><subject>Synaptic Transmission - genetics</subject><subject>Synaptic Transmission - physiology</subject><subject>Thalamic Nuclei - physiology</subject><subject>Transcriptional Activation</subject><issn>0736-7224</issn><issn>0899-0220</issn><issn>1369-1651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67j6ATwIOXlrTfpPOkEvyzKuC4uCu56bmuoKkyHdGZO0uuCHN8MMgogKgSJ57_co8hh7LsWrRgrzWmhjRF2bRpShdVc_YCvZKFNJ1cmHbCX6RlV9XbeP2ZOUdkII2Wt5xs50wXvdrtgPrGxIfP19HyklF2buZn4VAZ0PeQseJof8rtwz_0BLDHPiYDNFvvaEOToEz2-zmxYP-UAHy_OW-PW8WyKN_BZdecfCxq90iD6IF-PiM_8E-Sl7ZMEnenaa5-zzu_Xd5fvq5uPV9eXFTYVtU-eqNRoUghWbBlF2CjulwPS91E2PqEahtELV2Y1VmsZWaAJDHZaz0ZZ025yzl8fcfQxfFkp5mFxC8h5mCksaelXXyvT_N0qlTCe7phjl0YgxpBTJDvvoJoj3gxTDoZrhj2oK8-IUvmwmGn8Rpy6K_vaou9mGOMG3EP04ZLj3IdoIM7p0iP57_Jvf8C2Bz1uESMMuLHEuH_yP5X4CcCGv7A</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Persson, Jonas K. E.</creator><creator>Hongpaisan, Jarin</creator><creator>Molander, Carl</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>c-fos Expression in Gracilothalamic Tract Neurons after Electrical Stimulation of the Injured Sciatic Nerve in the Adult Rat</title><author>Persson, Jonas K. E. ; Hongpaisan, Jarin ; Molander, Carl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-498a6caf0b3cc156c566a9771837cc6d0686c65fbf68ed408ea9e5ce5cb8fe843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>dorsal column</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Functional Laterality - physiology</topic><topic>Gene Expression Regulation - physiology</topic><topic>immediate early gene</topic><topic>Medulla Oblongata - physiology</topic><topic>Nerve Degeneration - genetics</topic><topic>Nerve Degeneration - physiology</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>nerve injury</topic><topic>nerve stimulation</topic><topic>Neuronal Plasticity - genetics</topic><topic>Neuronal Plasticity - physiology</topic><topic>plasticity</topic><topic>primary sensory neuron</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sciatic Nerve - injuries</topic><topic>Sciatic Nerve - physiology</topic><topic>Synaptic Transmission - genetics</topic><topic>Synaptic Transmission - physiology</topic><topic>Thalamic Nuclei - physiology</topic><topic>Transcriptional Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Persson, Jonas K. E.</creatorcontrib><creatorcontrib>Hongpaisan, Jarin</creatorcontrib><creatorcontrib>Molander, Carl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Somatosensory & motor research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Persson, Jonas K. E.</au><au>Hongpaisan, Jarin</au><au>Molander, Carl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>c-fos Expression in Gracilothalamic Tract Neurons after Electrical Stimulation of the Injured Sciatic Nerve in the Adult Rat</atitle><jtitle>Somatosensory & motor research</jtitle><addtitle>Somatosens Mot Res</addtitle><date>1993</date><risdate>1993</risdate><volume>10</volume><issue>4</issue><spage>475</spage><epage>483</epage><pages>475-483</pages><issn>0736-7224</issn><issn>0899-0220</issn><eissn>1369-1651</eissn><abstract>The number of c-fos protein-like immunoreactive (Fos-LI) cells in the gracile nucleus was determined after electrical stimulation at Aα/Aβ-fiber strength of the normal and of the previously injured sciatic nerve in adult rats. No Fos-LI cells were seen after electrical stimulation of the noninjured sciatic nerve, or after sciatic nerve injury without electrical stimulation. However, stimulation 21 days after sciatic nerve transection resulted in numerous Fos-LI cells in the ipsilateral gracile nucleus. Combined Fos immunocytochemistry and retrograde labeling from the thalamus showed that the majority (76%; range = 70-80%) of the cells in the gracile nucleus that expressed Fos-LI after nerve injury projected to the thalamus. The results indicate that morphological, biochemical, and physiological alterations in primary sensory central endings and second-order neurons, which have earlier been demonstrated in the dorsal column nuclei after peripheral nerve injury, are accompanied by changes in the c-fos gene activation pattern after stimulation of the injured sciatic nerve. A substantial number of the c-fos-expressing neurons project to the thalamus.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>8310784</pmid><doi>10.3109/08990229309028852</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals dorsal column Electric Stimulation Female Fluorescent Antibody Technique Functional Laterality - physiology Gene Expression Regulation - physiology immediate early gene Medulla Oblongata - physiology Nerve Degeneration - genetics Nerve Degeneration - physiology Nerve Fibers, Myelinated - physiology nerve injury nerve stimulation Neuronal Plasticity - genetics Neuronal Plasticity - physiology plasticity primary sensory neuron Proto-Oncogene Proteins c-fos - genetics Rats Rats, Sprague-Dawley Sciatic Nerve - injuries Sciatic Nerve - physiology Synaptic Transmission - genetics Synaptic Transmission - physiology Thalamic Nuclei - physiology Transcriptional Activation |
| title | c-fos Expression in Gracilothalamic Tract Neurons after Electrical Stimulation of the Injured Sciatic Nerve in the Adult Rat |
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