Differential modulation of contact hypersensitivity and delayed hypersensitivity reactions by topical application of 12-O-tetradecanoylphorbol-13-acetate

Ear/footpad swelling following sensitization and challenge with 2,4-dinitrofluorobenzene (DNFB)/allogenic splenocytes (AS) were used to monitor the effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on contact hypersensitivity (CHS) and delayed hypersensitivity (DHS) reactions, respectively. Topi...

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Veröffentlicht in:	Immunopharmacology and immunotoxicology 1993-11, Vol.15 (5), p.639-647
Hauptverfasser:	KODARI, E, PAVONE, A, REINERS, J. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Cocarcinogenesis Dermatitis, Contact - prevention & control Female Hypersensitivity, Delayed - prevention & control Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - toxicity Immunotherapy, Adoptive Medical sciences Mice Mice, Inbred C57BL Mice, Inbred Strains Skin Neoplasms - etiology Skin Neoplasms - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Tetradecanoylphorbol Acetate - administration & dosage Tetradecanoylphorbol Acetate - toxicity Tumors
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