Synthesis and enhancing effect of dodecyl 2-(N,N-dimethylamino)propionate on the transepidermal delivery of indomethacin, clonidine, and hydrocortisone

The biodegradable transdermal penetration enhancer, dodecyl 2-(N,N-dimethylamino)propionate (II; DDAIP), was prepared by reacting dodecyl 2-bromopropionate (I), obtained by reaction of n-dodecanol with 2-bromopropionyl halogenide, with dimethylamine. The penetration enhancing effects of DDAIP on the...

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Veröffentlicht in:	Pharmaceutical research 1993-11, Vol.10 (11), p.1632-1637
Hauptverfasser:	BÜYÜKTIMKIN, S, BÜYÜKTIMKIN, N, RYTTING, J. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Alanine - analogs & derivatives Alanine - chemical synthesis Alanine - pharmacology Animals Biodegradation, Environmental Biological and medical sciences Clonidine - administration & dosage Colubridae General pharmacology Hydrocortisone - administration & dosage In Vitro Techniques Indomethacin - administration & dosage Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin Absorption - drug effects
Online-Zugang:	Volltext
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