Cerebellar Dysgenesis in Rats by Diaplacental Effects of 7,12-Dimethylbenz [a]anthracene
7,12-Dimethylbenz[a]anthracene (DMBA) administered iv to pregnant Sprague-Dawley rats produced cerebellar malfunction in at least 10% of the offspring. The underlying morphologic basis of the cerebellar symptomatology was found in maldevelopment of cerebellar cortex, ranging from focal loss of granu...
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1976-05, Vol.56 (5), p.1063-1067 |
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| container_title | JNCI : Journal of the National Cancer Institute |
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| creator | Kellen, J. A. Kolin, A. Fletch, A. L. |
| description | 7,12-Dimethylbenz[a]anthracene (DMBA) administered iv to pregnant Sprague-Dawley rats produced cerebellar malfunction in at least 10% of the offspring. The underlying morphologic basis of the cerebellar symptomatology was found in maldevelopment of cerebellar cortex, ranging from focal loss of granule and Purkinje's cell layers to extensive areas of cortical disorganization with losses of granule neurons. An interference with the proliferation of the granule cell-layer primordium was suggested as a mechanism of this cerebellar dysgenesis. After a 200-day observation, no tumors were found in the offspring of the DMBA-treated, pregnant rats. |
| doi_str_mv | 10.1093/jnci/56.5.1063 |
| format | Article |
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A.</creatorcontrib><creatorcontrib>Kolin, A.</creatorcontrib><creatorcontrib>Fletch, A. L.</creatorcontrib><title>Cerebellar Dysgenesis in Rats by Diaplacental Effects of 7,12-Dimethylbenz [a]anthracene</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>7,12-Dimethylbenz[a]anthracene (DMBA) administered iv to pregnant Sprague-Dawley rats produced cerebellar malfunction in at least 10% of the offspring. The underlying morphologic basis of the cerebellar symptomatology was found in maldevelopment of cerebellar cortex, ranging from focal loss of granule and Purkinje's cell layers to extensive areas of cortical disorganization with losses of granule neurons. An interference with the proliferation of the granule cell-layer primordium was suggested as a mechanism of this cerebellar dysgenesis. After a 200-day observation, no tumors were found in the offspring of the DMBA-treated, pregnant rats.</description><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity</subject><subject>Abnormalities, Drug-Induced - pathology</subject><subject>Animals</subject><subject>Benz(a)Anthracenes - toxicity</subject><subject>Cerebellum - abnormalities</subject><subject>Cerebellum - pathology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Maternal-Fetal Exchange</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Teratogens</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLw0AUhQfxVatbVy7mBzjtvGeylKa1YkEUlaJImKR37NQ0LZkIxl9vpOLZHO75DhcOQueMDhhNxHBVFWGo9EB1pxZ7qMekpoQzqvZRj1JuiLVGHqOTGFe0U8LlETq0XGnFemg-ghpyKEtX47SN71BBDBGHCj-4JuK8xWlw29IVUDWuxGPvoejyjcfmknGShjU0y7bMofrGr-7NVc2y_i3DKTrwroxw9ud99DQZP46mZHZ3fTO6mpHApWgIA2U8Z4xKIxeWiiIRhXVgJIDQigIwlTDvrbI5CJrIRS5tIhUwbVUhuRF9dLH7u_3M17DItnVYu7rNdgM7THY4xAa-_qmrPzJthFHZdP6SPdP5bHKf3mZG_AD5EWCx</recordid><startdate>197605</startdate><enddate>197605</enddate><creator>Kellen, J. A.</creator><creator>Kolin, A.</creator><creator>Fletch, A. L.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197605</creationdate><title>Cerebellar Dysgenesis in Rats by Diaplacental Effects of 7,12-Dimethylbenz [a]anthracene</title><author>Kellen, J. A. ; Kolin, A. ; Fletch, A. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i243t-1e57f2110474d803c93c8ae74ee3650ee1591ff858be3094db48945e1685c4273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - toxicity</topic><topic>Abnormalities, Drug-Induced - pathology</topic><topic>Animals</topic><topic>Benz(a)Anthracenes - toxicity</topic><topic>Cerebellum - abnormalities</topic><topic>Cerebellum - pathology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Maternal-Fetal Exchange</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Teratogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kellen, J. A.</creatorcontrib><creatorcontrib>Kolin, A.</creatorcontrib><creatorcontrib>Fletch, A. 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L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebellar Dysgenesis in Rats by Diaplacental Effects of 7,12-Dimethylbenz [a]anthracene</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1976-05</date><risdate>1976</risdate><volume>56</volume><issue>5</issue><spage>1063</spage><epage>1067</epage><pages>1063-1067</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>7,12-Dimethylbenz[a]anthracene (DMBA) administered iv to pregnant Sprague-Dawley rats produced cerebellar malfunction in at least 10% of the offspring. The underlying morphologic basis of the cerebellar symptomatology was found in maldevelopment of cerebellar cortex, ranging from focal loss of granule and Purkinje's cell layers to extensive areas of cortical disorganization with losses of granule neurons. An interference with the proliferation of the granule cell-layer primordium was suggested as a mechanism of this cerebellar dysgenesis. After a 200-day observation, no tumors were found in the offspring of the DMBA-treated, pregnant rats.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>825651</pmid><doi>10.1093/jnci/56.5.1063</doi><tpages>5</tpages></addata></record> |
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| ispartof | JNCI : Journal of the National Cancer Institute, 1976-05, Vol.56 (5), p.1063-1067 |
| issn | 0027-8874 1460-2105 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | 9,10-Dimethyl-1,2-benzanthracene - toxicity Abnormalities, Drug-Induced - pathology Animals Benz(a)Anthracenes - toxicity Cerebellum - abnormalities Cerebellum - pathology Female Gestational Age Maternal-Fetal Exchange Pregnancy Rats Teratogens |
| title | Cerebellar Dysgenesis in Rats by Diaplacental Effects of 7,12-Dimethylbenz [a]anthracene |
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