Nematocidal Activity of Turmeric : Synergistic Action of Curcuminoids
A new curcuminoid, cyclocurcumin (IV), was isolated from the nematocidally active fraction of turmeric, the rhizome of Curcuma longa, together with three known curcuminoids, curcumin (I), demethoxycurcumin (II) and bisdemethoxycurcumin (III). The structure of IV was elucidated on the basis of spectr...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1993/09/15, Vol.41(9), pp.1640-1643 |
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| container_issue | 9 |
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| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 41 |
| creator | KIUCHI, Fumiyuki GOTO, Yoshihisa SUGIMOTO, Naoki AKAO, Nobuaki KONDO, Kaoru TSUDA, Yoshisuke |
| description | A new curcuminoid, cyclocurcumin (IV), was isolated from the nematocidally active fraction of turmeric, the rhizome of Curcuma longa, together with three known curcuminoids, curcumin (I), demethoxycurcumin (II) and bisdemethoxycurcumin (III). The structure of IV was elucidated on the basis of spectral data and confirmed by the partial synthesis from curcumin (I). Although the above curcuminoids were ineffective when they were applied independently, the nematocidal activity increased remarkably when they were mixed, suggesting a synergistic action between them. |
| doi_str_mv | 10.1248/cpb.41.1640 |
| format | Article |
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The structure of IV was elucidated on the basis of spectral data and confirmed by the partial synthesis from curcumin (I). Although the above curcuminoids were ineffective when they were applied independently, the nematocidal activity increased remarkably when they were mixed, suggesting a synergistic action between them.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.41.1640</identifier><identifier>PMID: 8221978</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antinematodal Agents - pharmacology ; Biological and medical sciences ; Curcuma longa ; Curcumin - analogs & derivatives ; Curcumin - analysis ; Curcumin - pharmacology ; curcuminoid ; cyclocurcumin ; Drug Synergism ; General pharmacology ; Medical sciences ; nematocidal activity ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Spices - analysis ; synergistic effect ; Toxocara canis - drug effects ; turmeric</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1993/09/15, Vol.41(9), pp.1640-1643</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3949209$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8221978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIUCHI, Fumiyuki</creatorcontrib><creatorcontrib>GOTO, Yoshihisa</creatorcontrib><creatorcontrib>SUGIMOTO, Naoki</creatorcontrib><creatorcontrib>AKAO, Nobuaki</creatorcontrib><creatorcontrib>KONDO, Kaoru</creatorcontrib><creatorcontrib>TSUDA, Yoshisuke</creatorcontrib><title>Nematocidal Activity of Turmeric : Synergistic Action of Curcuminoids</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>A new curcuminoid, cyclocurcumin (IV), was isolated from the nematocidally active fraction of turmeric, the rhizome of Curcuma longa, together with three known curcuminoids, curcumin (I), demethoxycurcumin (II) and bisdemethoxycurcumin (III). The structure of IV was elucidated on the basis of spectral data and confirmed by the partial synthesis from curcumin (I). Although the above curcuminoids were ineffective when they were applied independently, the nematocidal activity increased remarkably when they were mixed, suggesting a synergistic action between them.</description><subject>Animals</subject><subject>Antinematodal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Curcuma longa</subject><subject>Curcumin - analogs & derivatives</subject><subject>Curcumin - analysis</subject><subject>Curcumin - pharmacology</subject><subject>curcuminoid</subject><subject>cyclocurcumin</subject><subject>Drug Synergism</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>nematocidal activity</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Spices - analysis</subject><subject>synergistic effect</subject><subject>Toxocara canis - drug effects</subject><subject>turmeric</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEURoMotVZXroVZuJ2a5GbycFfa-oCiC-t6yGSSmjKPkswI_fdOaambe7mcw4XvQ-ie4CmhTD6ZXTFlZEo4wxdoTICJNKMULtEYY6xSChyu0U2MW4xphgWM0EhSSpSQY7T8sLXuWuNLXSUz0_lf3-2T1iXrPtQ2eJM8J1_7xoaNj91wHZS2OQjzPpi-9k3ry3iLrpyuor077Qn6flmu52_p6vP1fT5bpVtQpEsFB11IbEzGpAIrSGkyy50jiltQpsQOSioIWCi14dZJyKjGXEvHieBFARP0cPy764valvku-FqHfX6KM_DHE9fR6MoF3RgfzxoopihWg7Y4atvY6Y09cx2GiJXNh0KJymTOSK6O49DtP_7RIbcN_AFSLXCt</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>KIUCHI, Fumiyuki</creator><creator>GOTO, Yoshihisa</creator><creator>SUGIMOTO, Naoki</creator><creator>AKAO, Nobuaki</creator><creator>KONDO, Kaoru</creator><creator>TSUDA, Yoshisuke</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19930901</creationdate><title>Nematocidal Activity of Turmeric : Synergistic Action of Curcuminoids</title><author>KIUCHI, Fumiyuki ; GOTO, Yoshihisa ; SUGIMOTO, Naoki ; AKAO, Nobuaki ; KONDO, Kaoru ; TSUDA, Yoshisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j391t-763ab80cc54893e71dc5e6ff196e39cd0f3d2713e3dac6ef8352a06a8f6176bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antinematodal Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Curcuma longa</topic><topic>Curcumin - analogs & derivatives</topic><topic>Curcumin - analysis</topic><topic>Curcumin - pharmacology</topic><topic>curcuminoid</topic><topic>cyclocurcumin</topic><topic>Drug Synergism</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>nematocidal activity</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Spices - analysis</topic><topic>synergistic effect</topic><topic>Toxocara canis - drug effects</topic><topic>turmeric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIUCHI, Fumiyuki</creatorcontrib><creatorcontrib>GOTO, Yoshihisa</creatorcontrib><creatorcontrib>SUGIMOTO, Naoki</creatorcontrib><creatorcontrib>AKAO, Nobuaki</creatorcontrib><creatorcontrib>KONDO, Kaoru</creatorcontrib><creatorcontrib>TSUDA, Yoshisuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIUCHI, Fumiyuki</au><au>GOTO, Yoshihisa</au><au>SUGIMOTO, Naoki</au><au>AKAO, Nobuaki</au><au>KONDO, Kaoru</au><au>TSUDA, Yoshisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nematocidal Activity of Turmeric : Synergistic Action of Curcuminoids</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>41</volume><issue>9</issue><spage>1640</spage><epage>1643</epage><pages>1640-1643</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>A new curcuminoid, cyclocurcumin (IV), was isolated from the nematocidally active fraction of turmeric, the rhizome of Curcuma longa, together with three known curcuminoids, curcumin (I), demethoxycurcumin (II) and bisdemethoxycurcumin (III). The structure of IV was elucidated on the basis of spectral data and confirmed by the partial synthesis from curcumin (I). Although the above curcuminoids were ineffective when they were applied independently, the nematocidal activity increased remarkably when they were mixed, suggesting a synergistic action between them.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8221978</pmid><doi>10.1248/cpb.41.1640</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1993/09/15, Vol.41(9), pp.1640-1643 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_pubmed_primary_8221978 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Antinematodal Agents - pharmacology Biological and medical sciences Curcuma longa Curcumin - analogs & derivatives Curcumin - analysis Curcumin - pharmacology curcuminoid cyclocurcumin Drug Synergism General pharmacology Medical sciences nematocidal activity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Spices - analysis synergistic effect Toxocara canis - drug effects turmeric |
| title | Nematocidal Activity of Turmeric : Synergistic Action of Curcuminoids |
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