Toxicity grading systems : a comparison between the WHO scoring system and the Common Toxicity Criteria when used for nausea and vomiting
The Common Toxicity Criteria adopted by the NCI in the USA for grading toxicity in cancer clinical trials have been compared to the WHO scoring system which is still in use in Europe. Sixty-six patients undergoing emetic chemotherapy at the Netherlands Cancer Institute completed questionnaires, 32 a...
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| Veröffentlicht in: | Annals of oncology 1994-02, Vol.5 (2), p.113-117 |
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| container_title | Annals of oncology |
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| creator | FRANKLIN, H. R SIMONETTI, G. P. C DUBBELMAN, A. C TEN BOKKEL HUININK, W. W TAAL, B. G WIGBOUT, G MANDJES, I. A DALESIO, O. B AARONSON, N. K |
| description | The Common Toxicity Criteria adopted by the NCI in the USA for grading toxicity in cancer clinical trials have been compared to the WHO scoring system which is still in use in Europe.
Sixty-six patients undergoing emetic chemotherapy at the Netherlands Cancer Institute completed questionnaires, 32 according to the WHO criteria and 34 to the Common Toxicity Criteria, on the severity, frequency and duration of gastro-intestinal toxicity. Their answers were then compared to the scores coded by research nurses and physicians. The nurses coded acute toxicity when the patients were discharged, and the doctors coded overall toxicity when the patients returned for the subsequent course of chemotherapy. To evaluate the coding systems, an estimate was made of the percentage agreement between the patients' answers and the nurses' and doctors' ratings.
The percentage agreement of the Common Toxicity Criteria with the patients' own experiences of nausea and vomiting was considerably better than that of the WHO score. The Gamma statistic confirmed this. The Common Toxicity Criteria have now been adopted for grading toxicity in studies of the Early Clinical Trials Group of the EORTC and are recommended for use in other clinical trials. |
| doi_str_mv | 10.1093/oxfordjournals.annonc.a058760 |
| format | Article |
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Sixty-six patients undergoing emetic chemotherapy at the Netherlands Cancer Institute completed questionnaires, 32 according to the WHO criteria and 34 to the Common Toxicity Criteria, on the severity, frequency and duration of gastro-intestinal toxicity. Their answers were then compared to the scores coded by research nurses and physicians. The nurses coded acute toxicity when the patients were discharged, and the doctors coded overall toxicity when the patients returned for the subsequent course of chemotherapy. To evaluate the coding systems, an estimate was made of the percentage agreement between the patients' answers and the nurses' and doctors' ratings.
The percentage agreement of the Common Toxicity Criteria with the patients' own experiences of nausea and vomiting was considerably better than that of the WHO score. The Gamma statistic confirmed this. The Common Toxicity Criteria have now been adopted for grading toxicity in studies of the Early Clinical Trials Group of the EORTC and are recommended for use in other clinical trials.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/oxfordjournals.annonc.a058760</identifier><identifier>PMID: 8186153</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Clinical Trials as Topic ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Nausea - chemically induced ; Pharmacology. Drug treatments ; Surveys and Questionnaires ; Vomiting - chemically induced ; World Health Organization</subject><ispartof>Annals of oncology, 1994-02, Vol.5 (2), p.113-117</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3955360$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8186153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRANKLIN, H. R</creatorcontrib><creatorcontrib>SIMONETTI, G. P. C</creatorcontrib><creatorcontrib>DUBBELMAN, A. C</creatorcontrib><creatorcontrib>TEN BOKKEL HUININK, W. W</creatorcontrib><creatorcontrib>TAAL, B. G</creatorcontrib><creatorcontrib>WIGBOUT, G</creatorcontrib><creatorcontrib>MANDJES, I. A</creatorcontrib><creatorcontrib>DALESIO, O. B</creatorcontrib><creatorcontrib>AARONSON, N. K</creatorcontrib><title>Toxicity grading systems : a comparison between the WHO scoring system and the Common Toxicity Criteria when used for nausea and vomiting</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>The Common Toxicity Criteria adopted by the NCI in the USA for grading toxicity in cancer clinical trials have been compared to the WHO scoring system which is still in use in Europe.
Sixty-six patients undergoing emetic chemotherapy at the Netherlands Cancer Institute completed questionnaires, 32 according to the WHO criteria and 34 to the Common Toxicity Criteria, on the severity, frequency and duration of gastro-intestinal toxicity. Their answers were then compared to the scores coded by research nurses and physicians. The nurses coded acute toxicity when the patients were discharged, and the doctors coded overall toxicity when the patients returned for the subsequent course of chemotherapy. To evaluate the coding systems, an estimate was made of the percentage agreement between the patients' answers and the nurses' and doctors' ratings.
The percentage agreement of the Common Toxicity Criteria with the patients' own experiences of nausea and vomiting was considerably better than that of the WHO score. The Gamma statistic confirmed this. The Common Toxicity Criteria have now been adopted for grading toxicity in studies of the Early Clinical Trials Group of the EORTC and are recommended for use in other clinical trials.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Nausea - chemically induced</subject><subject>Pharmacology. 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Sixty-six patients undergoing emetic chemotherapy at the Netherlands Cancer Institute completed questionnaires, 32 according to the WHO criteria and 34 to the Common Toxicity Criteria, on the severity, frequency and duration of gastro-intestinal toxicity. Their answers were then compared to the scores coded by research nurses and physicians. The nurses coded acute toxicity when the patients were discharged, and the doctors coded overall toxicity when the patients returned for the subsequent course of chemotherapy. To evaluate the coding systems, an estimate was made of the percentage agreement between the patients' answers and the nurses' and doctors' ratings.
The percentage agreement of the Common Toxicity Criteria with the patients' own experiences of nausea and vomiting was considerably better than that of the WHO score. The Gamma statistic confirmed this. The Common Toxicity Criteria have now been adopted for grading toxicity in studies of the Early Clinical Trials Group of the EORTC and are recommended for use in other clinical trials.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8186153</pmid><doi>10.1093/oxfordjournals.annonc.a058760</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of oncology, 1994-02, Vol.5 (2), p.113-117 |
| issn | 0923-7534 1569-8041 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Antineoplastic Agents - adverse effects Biological and medical sciences Clinical Trials as Topic Drug toxicity and drugs side effects treatment Female Humans Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Nausea - chemically induced Pharmacology. Drug treatments Surveys and Questionnaires Vomiting - chemically induced World Health Organization |
| title | Toxicity grading systems : a comparison between the WHO scoring system and the Common Toxicity Criteria when used for nausea and vomiting |
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