Effects of chronic phorbol ester treatment on protein kinase C activity, content, and gene expression in the human monoblastoid U937 cell

Immediate and sustained signal transduction is involved in mediating phorbol ester-induced changes in growth and differentiation. Activation of protein kinase C (PKC) is the initial step in phorbol ester-induced signal transduction. By virtue of preferential down-regulation of individual isoforms an...

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Veröffentlicht in:	Cell growth & differentiation 1994-02, Vol.5 (2), p.161-169
Hauptverfasser:	WAYS, D. K, WEIXI QIN, GARRIS, T. O, JIANMING CHEN, ENHUI HAO, COOPER, D. R, USALA, S. J, PARKER, P. J, COOK, P. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence beta-Galactosidase - biosynthesis beta-Galactosidase - metabolism Binding Sites Biological and medical sciences Blotting, Western Brain - enzymology Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Line Cell physiology Chloramphenicol O-Acetyltransferase - biosynthesis Chloramphenicol O-Acetyltransferase - metabolism Collagenases - genetics DNA-Binding Proteins - biosynthesis Dose-Response Relationship, Drug Early Growth Response Protein 1 Enhancer Elements, Genetic Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, jun Humans Immediate-Early Proteins Kinetics Leukemia Molecular and cellular biology Molecular Sequence Data Oligodeoxyribonucleotides - metabolism Promoter Regions, Genetic Protein Kinase C - analysis Protein Kinase C - biosynthesis Protein Kinase C - metabolism Proto-Oncogene Proteins c-jun - biosynthesis Proto-Oncogene Proteins c-jun - metabolism Proto-Oncogenes Tetradecanoylphorbol Acetate - pharmacology Transcription Factors - biosynthesis Transfection Tumor Cells, Cultured
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