Two Point Mutations within the Adducin Genes are Involved in Blood Pressure Variation

The Milan hypertensive strain of rats (MHS) develops a genetic form of renal hypertension that, when compared to its normotensive control (MNS), shows renal dysfunction similar to that of a subset of human patients with primary hypertension. MHS and MNS were shown to be homozygous by multilocus mini...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-04, Vol.91 (9), p.3999-4003
Hauptverfasser:	Bianchi, Giuseppe, Tripodi, Grazia, Casari, Giorgio, Salardi, Sergio, Barber, Barry R., Garcia, Rodolfo, Leoni, Patricia, Torielli, Lucia, Cusi, Daniele, Ferrandi, Mara, Pinna, Lorenzo A., Baralle, Francisco E., Ferrari, Patrizia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Animals Arterial hypertension. Arterial hypotension Base Sequence Biological and medical sciences Blood and lymphatic vessels Blood Pressure Calmodulin-Binding Proteins - genetics Cardiology. Vascular system Cell membranes Clinical manifestations. Epidemiology. Investigative techniques. Etiology DNA Primers - chemistry Female Genotypes Heterozygote Human genetics Hypertension Hypertension - genetics Male Medical genetics Medical research Medical sciences Molecular Sequence Data Peptides - chemistry Phosphoproteins - metabolism Phosphorylation Polymorphism, Genetic Rats Rodents Systolic blood pressure
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