Myeloid Leukaemia and Osteosarcoma in CBA/H Mice Given 224Ra
Four groups of 400 12-week-old CBA/H mice were injected i.p. with 69, 139, 280 and 550 Bqg−1 224Ra. A further group of 400 mice were injected i.p. with diluting solution only. The mice were then allowed unrestricted access to food and water until they died or were killed. 53 cases of myeloid leukaem...
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| Veröffentlicht in: | International journal of radiation biology 1993-08, Vol.64 (2), p.231-235 |
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| container_title | International journal of radiation biology |
| container_volume | 64 |
| creator | Humphreys, E.R. Isaacs, K.R. Raine, T.A. Saunders, J. Stones, V.A. Wood, D.L. |
| description | Four groups of 400 12-week-old CBA/H mice were injected i.p. with 69, 139, 280 and 550 Bqg−1 224Ra. A further group of 400 mice were injected i.p. with diluting solution only. The mice were then allowed unrestricted access to food and water until they died or were killed. 53 cases of myeloid leukaemia and 22 cases of osteosarcoma were confirmed in the 2000 mice injected, and for both tumour types direct relationships were shown to exist between the amount of 224Ra administered and the incidence of tumours. It is concluded that mouse is at a greater risk from myeloid leukaemia than from osteosarcoma in the region of administered 224Ra below that which causes a maximum yield of osteosarcoma. These results are discussed in the light of the present acceptance of osteosarcoma as the major risk to man from bone-seeking α-particle emitters. |
| doi_str_mv | 10.1080/09553009314551341 |
| format | Article |
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A further group of 400 mice were injected i.p. with diluting solution only. The mice were then allowed unrestricted access to food and water until they died or were killed. 53 cases of myeloid leukaemia and 22 cases of osteosarcoma were confirmed in the 2000 mice injected, and for both tumour types direct relationships were shown to exist between the amount of 224Ra administered and the incidence of tumours. It is concluded that mouse is at a greater risk from myeloid leukaemia than from osteosarcoma in the region of administered 224Ra below that which causes a maximum yield of osteosarcoma. These results are discussed in the light of the present acceptance of osteosarcoma as the major risk to man from bone-seeking α-particle emitters.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553009314551341</identifier><identifier>PMID: 8103548</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Animals ; Biological and medical sciences ; Hematologic and hematopoietic diseases ; Leukemia, Myeloid - etiology ; Male ; Medical sciences ; Mice ; Mice, Inbred CBA ; Neoplasms, Radiation-Induced ; Osteosarcoma - etiology ; Other diseases. 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A further group of 400 mice were injected i.p. with diluting solution only. The mice were then allowed unrestricted access to food and water until they died or were killed. 53 cases of myeloid leukaemia and 22 cases of osteosarcoma were confirmed in the 2000 mice injected, and for both tumour types direct relationships were shown to exist between the amount of 224Ra administered and the incidence of tumours. It is concluded that mouse is at a greater risk from myeloid leukaemia than from osteosarcoma in the region of administered 224Ra below that which causes a maximum yield of osteosarcoma. These results are discussed in the light of the present acceptance of osteosarcoma as the major risk to man from bone-seeking α-particle emitters.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Leukemia, Myeloid - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Neoplasms, Radiation-Induced</subject><subject>Osteosarcoma - etiology</subject><subject>Other diseases. 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Hematologic involvement in other diseases</topic><topic>Radium - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Humphreys, E.R.</creatorcontrib><creatorcontrib>Isaacs, K.R.</creatorcontrib><creatorcontrib>Raine, T.A.</creatorcontrib><creatorcontrib>Saunders, J.</creatorcontrib><creatorcontrib>Stones, V.A.</creatorcontrib><creatorcontrib>Wood, D.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Humphreys, E.R.</au><au>Isaacs, K.R.</au><au>Raine, T.A.</au><au>Saunders, J.</au><au>Stones, V.A.</au><au>Wood, D.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myeloid Leukaemia and Osteosarcoma in CBA/H Mice Given 224Ra</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1993-08</date><risdate>1993</risdate><volume>64</volume><issue>2</issue><spage>231</spage><epage>235</epage><pages>231-235</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Four groups of 400 12-week-old CBA/H mice were injected i.p. with 69, 139, 280 and 550 Bqg−1 224Ra. A further group of 400 mice were injected i.p. with diluting solution only. The mice were then allowed unrestricted access to food and water until they died or were killed. 53 cases of myeloid leukaemia and 22 cases of osteosarcoma were confirmed in the 2000 mice injected, and for both tumour types direct relationships were shown to exist between the amount of 224Ra administered and the incidence of tumours. It is concluded that mouse is at a greater risk from myeloid leukaemia than from osteosarcoma in the region of administered 224Ra below that which causes a maximum yield of osteosarcoma. These results are discussed in the light of the present acceptance of osteosarcoma as the major risk to man from bone-seeking α-particle emitters.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>8103548</pmid><doi>10.1080/09553009314551341</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of radiation biology, 1993-08, Vol.64 (2), p.231-235 |
| issn | 0955-3002 1362-3095 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Biological and medical sciences Hematologic and hematopoietic diseases Leukemia, Myeloid - etiology Male Medical sciences Mice Mice, Inbred CBA Neoplasms, Radiation-Induced Osteosarcoma - etiology Other diseases. Hematologic involvement in other diseases Radium - toxicity |
| title | Myeloid Leukaemia and Osteosarcoma in CBA/H Mice Given 224Ra |
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