Metabolic Reduction of Benzidine Azo Dyes to Benzidine in the Rhesus Monkey

Rhesus monkeys were fed azo dyes derived from benzidine (a known human bladder carcinogen). The urinary excretion of free benzidine was assayed and compared to the amount excreted when benzidine itself was fed. A substantial amount of the dye fed was converted to free benzidine. Results indicate tha...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1975-07, Vol.55 (1), p.181-182
Hauptverfasser:	Rinde, Esther, Troll, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobiphenyl Compounds - metabolism Animals Azo Compounds - metabolism Benzidines - metabolism Benzidines - urine Coloring Agents - adverse effects Coloring Agents - metabolism Environmental Exposure Environmental Pollutants Haplorhini Macaca mulatta
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creator	Rinde, Esther Troll, Walter
description	Rhesus monkeys were fed azo dyes derived from benzidine (a known human bladder carcinogen). The urinary excretion of free benzidine was assayed and compared to the amount excreted when benzidine itself was fed. A substantial amount of the dye fed was converted to free benzidine. Results indicate that the simple precaution in the use of only azo dyes manufactured from noncarcinogenic aromatic amines, e.g., aniline, for all consumer products appears prudent
doi_str_mv	10.1093/jnci/55.1.181
format	Article
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The urinary excretion of free benzidine was assayed and compared to the amount excreted when benzidine itself was fed. A substantial amount of the dye fed was converted to free benzidine. Results indicate that the simple precaution in the use of only azo dyes manufactured from noncarcinogenic aromatic amines, e.g., aniline, for all consumer products appears prudent</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/55.1.181</identifier><identifier>PMID: 808635</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aminobiphenyl Compounds - metabolism ; Animals ; Azo Compounds - metabolism ; Benzidines - metabolism ; Benzidines - urine ; Coloring Agents - adverse effects ; Coloring Agents - metabolism ; Environmental Exposure ; Environmental Pollutants ; Haplorhini ; Macaca mulatta</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1975-07, Vol.55 (1), p.181-182</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/808635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rinde, Esther</creatorcontrib><creatorcontrib>Troll, Walter</creatorcontrib><title>Metabolic Reduction of Benzidine Azo Dyes to Benzidine in the Rhesus Monkey</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Rhesus monkeys were fed azo dyes derived from benzidine (a known human bladder carcinogen). The urinary excretion of free benzidine was assayed and compared to the amount excreted when benzidine itself was fed. A substantial amount of the dye fed was converted to free benzidine. 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The urinary excretion of free benzidine was assayed and compared to the amount excreted when benzidine itself was fed. A substantial amount of the dye fed was converted to free benzidine. Results indicate that the simple precaution in the use of only azo dyes manufactured from noncarcinogenic aromatic amines, e.g., aniline, for all consumer products appears prudent</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>808635</pmid><doi>10.1093/jnci/55.1.181</doi><tpages>2</tpages></addata></record>
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source	MEDLINE; Oxford University Press Journals Digital Archive Legacy
subjects	Aminobiphenyl Compounds - metabolism Animals Azo Compounds - metabolism Benzidines - metabolism Benzidines - urine Coloring Agents - adverse effects Coloring Agents - metabolism Environmental Exposure Environmental Pollutants Haplorhini Macaca mulatta
title	Metabolic Reduction of Benzidine Azo Dyes to Benzidine in the Rhesus Monkey
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