Acute Renal Failure in a Medical Setting: Changing Patterns and Prognostic Factors
The clinical characteristics of 118 patients (60 male) with acute renal failure (ARF) admitted between 1980 and 1991, were retrospectively analyzed and compared with our earlier series of the 1960s. The mean age was 53 years (16-82 years). There was a marked decline in the hypotension-related cases...
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| Veröffentlicht in: | Renal failure 1994, Vol.16 (2), p.273-284 |
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| container_title | Renal failure |
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| creator | Alexopoulos, Efstathios Vakianis, Pantelis Kokolina, Elisabeth Koukoudis, Paraschos Sakellariou, George Memmos, Dimitrios Papadimitriou, Menelaos |
| description | The clinical characteristics of 118 patients (60 male) with acute renal failure (ARF) admitted between 1980 and 1991, were retrospectively analyzed and compared with our earlier series of the 1960s. The mean age was 53 years (16-82 years). There was a marked decline in the hypotension-related cases (43% vs. 17%, p < 0.01) and a concomitant increase in the nephro-toxic cases (5% vs. 17%, p < 0.005) in recent years. The number of ARF cases significantly decreased after 1986 (31%) compared to the pre-1986 era (69%, p |
| doi_str_mv | 10.3109/08860229409044867 |
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The mean age was 53 years (16-82 years). There was a marked decline in the hypotension-related cases (43% vs. 17%, p < 0.01) and a concomitant increase in the nephro-toxic cases (5% vs. 17%, p < 0.005) in recent years. The number of ARF cases significantly decreased after 1986 (31%) compared to the pre-1986 era (69%, p<0.001). A complete (35%) or partial recovery (55%) was the rule in the majority of the patients. The overall mortality was 27%, virtually unchanged in comparison to the 1960s (30%). However, a tendency toward lower mortality was seen after 1986 (17%) in comparison to before (32%, p<0.05). Sepsis and cardiovascular complications were the leading causes of death. Fewer deaths were observed among younger patients (< 30 years, 12.5%) compared to middle-aged patients (30-59 years, 34%, p<0.05) and to these older than 60s (53.5%, p<0.002). Also, deaths were rare in patients with only renal involvement (6%), increasing to 30% when 2 vital organ systems were affected (p<0.005) and to 67% in cases with multiple organ failure (p<0.001). Early institution of dialysis and the nonoliguric forms of the syndrome seem to be associated with better prognosis. In conclusion, the incidence of ARF has declined in recent years, with a concomitant tendency towards lower mortality. Death rate is mainly determined by the age and the number of organ involvement. Early dialysis seems to contribute to the lower mortality seen in recent cases.]]></description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.3109/08860229409044867</identifier><identifier>PMID: 8041966</identifier><identifier>CODEN: REFAE8</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Acute Kidney Injury - epidemiology ; Acute Kidney Injury - etiology ; Acute Kidney Injury - mortality ; Acute renal failure ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Dialysis ; Female ; Greece - epidemiology ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Mortality ; Multiple Organ Failure - mortality ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Prognosis ; Prognostic factors ; Renal failure ; Retrospective Studies ; Risk Factors</subject><ispartof>Renal failure, 1994, Vol.16 (2), p.273-284</ispartof><rights>1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-a34816a2f08c7823cf631160575e41d7144f18be1f52283568032fe90a930f763</citedby><cites>FETCH-LOGICAL-c430t-a34816a2f08c7823cf631160575e41d7144f18be1f52283568032fe90a930f763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08860229409044867$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08860229409044867$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59623,60412,61197,61378</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4111974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8041966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexopoulos, Efstathios</creatorcontrib><creatorcontrib>Vakianis, Pantelis</creatorcontrib><creatorcontrib>Kokolina, Elisabeth</creatorcontrib><creatorcontrib>Koukoudis, Paraschos</creatorcontrib><creatorcontrib>Sakellariou, George</creatorcontrib><creatorcontrib>Memmos, Dimitrios</creatorcontrib><creatorcontrib>Papadimitriou, Menelaos</creatorcontrib><title>Acute Renal Failure in a Medical Setting: Changing Patterns and Prognostic Factors</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description><![CDATA[The clinical characteristics of 118 patients (60 male) with acute renal failure (ARF) admitted between 1980 and 1991, were retrospectively analyzed and compared with our earlier series of the 1960s. The mean age was 53 years (16-82 years). There was a marked decline in the hypotension-related cases (43% vs. 17%, p < 0.01) and a concomitant increase in the nephro-toxic cases (5% vs. 17%, p < 0.005) in recent years. The number of ARF cases significantly decreased after 1986 (31%) compared to the pre-1986 era (69%, p<0.001). A complete (35%) or partial recovery (55%) was the rule in the majority of the patients. The overall mortality was 27%, virtually unchanged in comparison to the 1960s (30%). However, a tendency toward lower mortality was seen after 1986 (17%) in comparison to before (32%, p<0.05). Sepsis and cardiovascular complications were the leading causes of death. Fewer deaths were observed among younger patients (< 30 years, 12.5%) compared to middle-aged patients (30-59 years, 34%, p<0.05) and to these older than 60s (53.5%, p<0.002). Also, deaths were rare in patients with only renal involvement (6%), increasing to 30% when 2 vital organ systems were affected (p<0.005) and to 67% in cases with multiple organ failure (p<0.001). Early institution of dialysis and the nonoliguric forms of the syndrome seem to be associated with better prognosis. In conclusion, the incidence of ARF has declined in recent years, with a concomitant tendency towards lower mortality. Death rate is mainly determined by the age and the number of organ involvement. Early dialysis seems to contribute to the lower mortality seen in recent cases.]]></description><subject>Acute Kidney Injury - epidemiology</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - mortality</subject><subject>Acute renal failure</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Dialysis</subject><subject>Female</subject><subject>Greece - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple Organ Failure - mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Prognosis</subject><subject>Prognostic factors</subject><subject>Renal failure</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9LHDEUxUOp2PXPB-hDIQ99Hb03yWQybV9kqVpQFG3Bt-GaSXZHZjOSZBG_fSO7FYrg0w33nF_IOWHsM8KRRGiPwRgNQrQKWlDK6OYDm2Et6kqDaj-y2YteFcPdJ7aX0gMA1qYRu2zXgMJW6xm7ObHr7PiNCzTyUxrGdXR8CJz4pesHW5a3LuchLL7x-ZLCopz4NeXsYkicQs-v47QIU8qDLbjNU0wHbMfTmNzhdu6zP6c_f8_Pq4urs1_zk4vKKgm5IqkMahIejG2MkNZriaihbmqnsG9QKY_m3qGvhTCy1gak8K4FaiX4Rst9hpt7bZxSis53j3FYUXzuELqXero39RTmy4Z5XN-vXP9KbPso-tetTqmE95GCHdKrTSFi26hi-7GxDcFPcUVPUxz7LtPzOMV_jHzvFd__w5eOxry0FF33MK1j-Yr0Toa_n6yPyg</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Alexopoulos, Efstathios</creator><creator>Vakianis, Pantelis</creator><creator>Kokolina, Elisabeth</creator><creator>Koukoudis, Paraschos</creator><creator>Sakellariou, George</creator><creator>Memmos, Dimitrios</creator><creator>Papadimitriou, Menelaos</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1994</creationdate><title>Acute Renal Failure in a Medical Setting: Changing Patterns and Prognostic Factors</title><author>Alexopoulos, Efstathios ; Vakianis, Pantelis ; Kokolina, Elisabeth ; Koukoudis, Paraschos ; Sakellariou, George ; Memmos, Dimitrios ; Papadimitriou, Menelaos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-a34816a2f08c7823cf631160575e41d7144f18be1f52283568032fe90a930f763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acute Kidney Injury - epidemiology</topic><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - mortality</topic><topic>Acute renal failure</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Dialysis</topic><topic>Female</topic><topic>Greece - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple Organ Failure - mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Prognosis</topic><topic>Prognostic factors</topic><topic>Renal failure</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexopoulos, Efstathios</creatorcontrib><creatorcontrib>Vakianis, Pantelis</creatorcontrib><creatorcontrib>Kokolina, Elisabeth</creatorcontrib><creatorcontrib>Koukoudis, Paraschos</creatorcontrib><creatorcontrib>Sakellariou, George</creatorcontrib><creatorcontrib>Memmos, Dimitrios</creatorcontrib><creatorcontrib>Papadimitriou, Menelaos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexopoulos, Efstathios</au><au>Vakianis, Pantelis</au><au>Kokolina, Elisabeth</au><au>Koukoudis, Paraschos</au><au>Sakellariou, George</au><au>Memmos, Dimitrios</au><au>Papadimitriou, Menelaos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Renal Failure in a Medical Setting: Changing Patterns and Prognostic Factors</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>1994</date><risdate>1994</risdate><volume>16</volume><issue>2</issue><spage>273</spage><epage>284</epage><pages>273-284</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><coden>REFAE8</coden><abstract><![CDATA[The clinical characteristics of 118 patients (60 male) with acute renal failure (ARF) admitted between 1980 and 1991, were retrospectively analyzed and compared with our earlier series of the 1960s. The mean age was 53 years (16-82 years). There was a marked decline in the hypotension-related cases (43% vs. 17%, p < 0.01) and a concomitant increase in the nephro-toxic cases (5% vs. 17%, p < 0.005) in recent years. The number of ARF cases significantly decreased after 1986 (31%) compared to the pre-1986 era (69%, p<0.001). A complete (35%) or partial recovery (55%) was the rule in the majority of the patients. The overall mortality was 27%, virtually unchanged in comparison to the 1960s (30%). However, a tendency toward lower mortality was seen after 1986 (17%) in comparison to before (32%, p<0.05). Sepsis and cardiovascular complications were the leading causes of death. Fewer deaths were observed among younger patients (< 30 years, 12.5%) compared to middle-aged patients (30-59 years, 34%, p<0.05) and to these older than 60s (53.5%, p<0.002). Also, deaths were rare in patients with only renal involvement (6%), increasing to 30% when 2 vital organ systems were affected (p<0.005) and to 67% in cases with multiple organ failure (p<0.001). Early institution of dialysis and the nonoliguric forms of the syndrome seem to be associated with better prognosis. In conclusion, the incidence of ARF has declined in recent years, with a concomitant tendency towards lower mortality. Death rate is mainly determined by the age and the number of organ involvement. Early dialysis seems to contribute to the lower mortality seen in recent cases.]]></abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>8041966</pmid><doi>10.3109/08860229409044867</doi><tpages>12</tpages></addata></record> |
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| subjects | Acute Kidney Injury - epidemiology Acute Kidney Injury - etiology Acute Kidney Injury - mortality Acute renal failure Adolescent Adult Age Factors Aged Aged, 80 and over Biological and medical sciences Dialysis Female Greece - epidemiology Humans Incidence Male Medical sciences Middle Aged Mortality Multiple Organ Failure - mortality Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Prognosis Prognostic factors Renal failure Retrospective Studies Risk Factors |
| title | Acute Renal Failure in a Medical Setting: Changing Patterns and Prognostic Factors |
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