Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors

The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liv...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 1994-03, Vol.22 (3), p.211-217
Hauptverfasser:	KOSTENICH, G. A, ZHURAVKIN, I. N, ZHAVRID, E. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - drug effects Dose-Response Relationship, Drug Female Lethal Dose 50 Light Medical sciences Mice Mice, Inbred C3H Photochemotherapy Photoradiation therapy and photosensitizing agent Photosensitizing Agents - therapeutic use Photosensitizing Agents - toxicity Porphyrins - pharmacokinetics Porphyrins - therapeutic use Porphyrins - toxicity Radiation-Sensitizing Agents - therapeutic use Radiation-Sensitizing Agents - toxicity Rats Rats, Wistar Sarcoma, Experimental - drug therapy Sarcoma, Experimental - pathology Time Factors Tissue Distribution Treatment with physical agents Treatment. General aspects Tumors
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