Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors
The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liv...
Gespeichert in:
Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 1994-03, Vol.22 (3), p.211-217 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 217 |
---|---|
container_issue | 3 |
container_start_page | 211 |
container_title | Journal of photochemistry and photobiology. B, Biology |
container_volume | 22 |
creator | KOSTENICH, G. A ZHURAVKIN, I. N ZHAVRID, E. A |
description | The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liver, kidney, spleen and tumors (sarcoma M-1 and sarcoma 45) of the rats was determined by a fluorescence method, 3, 6, 12, 18, 24, 48 and 72 h after administration at a dose of 10 mg kg-1. For this purpose, chlorin e6 was extracted from tissues by the detergent Triton X-100. The depth of necrosis in sarcoma 45, the regression rate of sarcoma M-1 and the animal cure rate were evaluated after chlorin e6 administration at doses of 1-10 mg kg-1 and subsequent irradiation with krypton laser light. Depending on the dose and the time interval between chlorin e6 injection and irradiation, the depth of necrosis in sarcoma 45 varied from 5.0 to 15.0 mm. The cure rate of the animals with sarcoma M-1 varied from 10% to 60%. The antitumor effect was directly proportional to the chlorin e6 dose and light energy exposure and inversely proportional to the time interval between photosensitizer injection and irradiation. |
format | Article |
fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_8014753</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>8014753</sourcerecordid><originalsourceid>FETCH-LOGICAL-p823-5d0e5ce9d399d9e0c9c63648af5e38770cfa7e3c74bbecd36a617bedc5383a8d3</originalsourceid><addsrcrecordid>eNo9j0trwzAQhEVpSdO0P6GgQ68G2Ws9fCwhfUCgl1x6CmtpnbjYkpFsqP99XRq6h91hZxj4rtg6NxqyQpnietEiz7McyvKW3aX0JZaRSq_Yyoi81BLW7HP3PVBse_IjdvwUw-Rd4k2IfEqtP3F77kJsPSfFlz2eiQ_nMAY3e-xb-_uIOMw8NLzHrj159CMfpz7EdM9uGuwSPVzuhh1edoftW7b_eH3fPu-zwRSQSSdIWqocVJWrSNjKKlClwUYSGK2FbVATWF3WNVkHClWua3JWggE0Djbs8a92mOqe3HFYYDDOxwvh4j9dfEwWuyait236j4EUqhAKfgCbH1x4</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>KOSTENICH, G. A ; ZHURAVKIN, I. N ; ZHAVRID, E. A</creator><creatorcontrib>KOSTENICH, G. A ; ZHURAVKIN, I. N ; ZHAVRID, E. A</creatorcontrib><description>The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liver, kidney, spleen and tumors (sarcoma M-1 and sarcoma 45) of the rats was determined by a fluorescence method, 3, 6, 12, 18, 24, 48 and 72 h after administration at a dose of 10 mg kg-1. For this purpose, chlorin e6 was extracted from tissues by the detergent Triton X-100. The depth of necrosis in sarcoma 45, the regression rate of sarcoma M-1 and the animal cure rate were evaluated after chlorin e6 administration at doses of 1-10 mg kg-1 and subsequent irradiation with krypton laser light. Depending on the dose and the time interval between chlorin e6 injection and irradiation, the depth of necrosis in sarcoma 45 varied from 5.0 to 15.0 mm. The cure rate of the animals with sarcoma M-1 varied from 10% to 60%. The antitumor effect was directly proportional to the chlorin e6 dose and light energy exposure and inversely proportional to the time interval between photosensitizer injection and irradiation.</description><identifier>ISSN: 1011-1344</identifier><identifier>EISSN: 1873-2682</identifier><identifier>PMID: 8014753</identifier><identifier>CODEN: JPPBEG</identifier><language>eng</language><publisher>Lausanne: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Cell Division - drug effects ; Dose-Response Relationship, Drug ; Female ; Lethal Dose 50 ; Light ; Medical sciences ; Mice ; Mice, Inbred C3H ; Photochemotherapy ; Photoradiation therapy and photosensitizing agent ; Photosensitizing Agents - therapeutic use ; Photosensitizing Agents - toxicity ; Porphyrins - pharmacokinetics ; Porphyrins - therapeutic use ; Porphyrins - toxicity ; Radiation-Sensitizing Agents - therapeutic use ; Radiation-Sensitizing Agents - toxicity ; Rats ; Rats, Wistar ; Sarcoma, Experimental - drug therapy ; Sarcoma, Experimental - pathology ; Time Factors ; Tissue Distribution ; Treatment with physical agents ; Treatment. General aspects ; Tumors</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 1994-03, Vol.22 (3), p.211-217</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3506206$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8014753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOSTENICH, G. A</creatorcontrib><creatorcontrib>ZHURAVKIN, I. N</creatorcontrib><creatorcontrib>ZHAVRID, E. A</creatorcontrib><title>Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liver, kidney, spleen and tumors (sarcoma M-1 and sarcoma 45) of the rats was determined by a fluorescence method, 3, 6, 12, 18, 24, 48 and 72 h after administration at a dose of 10 mg kg-1. For this purpose, chlorin e6 was extracted from tissues by the detergent Triton X-100. The depth of necrosis in sarcoma 45, the regression rate of sarcoma M-1 and the animal cure rate were evaluated after chlorin e6 administration at doses of 1-10 mg kg-1 and subsequent irradiation with krypton laser light. Depending on the dose and the time interval between chlorin e6 injection and irradiation, the depth of necrosis in sarcoma 45 varied from 5.0 to 15.0 mm. The cure rate of the animals with sarcoma M-1 varied from 10% to 60%. The antitumor effect was directly proportional to the chlorin e6 dose and light energy exposure and inversely proportional to the time interval between photosensitizer injection and irradiation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Lethal Dose 50</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Photochemotherapy</subject><subject>Photoradiation therapy and photosensitizing agent</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Photosensitizing Agents - toxicity</subject><subject>Porphyrins - pharmacokinetics</subject><subject>Porphyrins - therapeutic use</subject><subject>Porphyrins - toxicity</subject><subject>Radiation-Sensitizing Agents - therapeutic use</subject><subject>Radiation-Sensitizing Agents - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sarcoma, Experimental - drug therapy</subject><subject>Sarcoma, Experimental - pathology</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Treatment with physical agents</subject><subject>Treatment. General aspects</subject><subject>Tumors</subject><issn>1011-1344</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0trwzAQhEVpSdO0P6GgQ68G2Ws9fCwhfUCgl1x6CmtpnbjYkpFsqP99XRq6h91hZxj4rtg6NxqyQpnietEiz7McyvKW3aX0JZaRSq_Yyoi81BLW7HP3PVBse_IjdvwUw-Rd4k2IfEqtP3F77kJsPSfFlz2eiQ_nMAY3e-xb-_uIOMw8NLzHrj159CMfpz7EdM9uGuwSPVzuhh1edoftW7b_eH3fPu-zwRSQSSdIWqocVJWrSNjKKlClwUYSGK2FbVATWF3WNVkHClWua3JWggE0Djbs8a92mOqe3HFYYDDOxwvh4j9dfEwWuyait236j4EUqhAKfgCbH1x4</recordid><startdate>199403</startdate><enddate>199403</enddate><creator>KOSTENICH, G. A</creator><creator>ZHURAVKIN, I. N</creator><creator>ZHAVRID, E. A</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199403</creationdate><title>Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors</title><author>KOSTENICH, G. A ; ZHURAVKIN, I. N ; ZHAVRID, E. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p823-5d0e5ce9d399d9e0c9c63648af5e38770cfa7e3c74bbecd36a617bedc5383a8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Lethal Dose 50</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Photochemotherapy</topic><topic>Photoradiation therapy and photosensitizing agent</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Photosensitizing Agents - toxicity</topic><topic>Porphyrins - pharmacokinetics</topic><topic>Porphyrins - therapeutic use</topic><topic>Porphyrins - toxicity</topic><topic>Radiation-Sensitizing Agents - therapeutic use</topic><topic>Radiation-Sensitizing Agents - toxicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sarcoma, Experimental - drug therapy</topic><topic>Sarcoma, Experimental - pathology</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Treatment with physical agents</topic><topic>Treatment. General aspects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOSTENICH, G. A</creatorcontrib><creatorcontrib>ZHURAVKIN, I. N</creatorcontrib><creatorcontrib>ZHAVRID, E. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOSTENICH, G. A</au><au>ZHURAVKIN, I. N</au><au>ZHAVRID, E. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors</atitle><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>1994-03</date><risdate>1994</risdate><volume>22</volume><issue>3</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>1011-1344</issn><eissn>1873-2682</eissn><coden>JPPBEG</coden><abstract>The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liver, kidney, spleen and tumors (sarcoma M-1 and sarcoma 45) of the rats was determined by a fluorescence method, 3, 6, 12, 18, 24, 48 and 72 h after administration at a dose of 10 mg kg-1. For this purpose, chlorin e6 was extracted from tissues by the detergent Triton X-100. The depth of necrosis in sarcoma 45, the regression rate of sarcoma M-1 and the animal cure rate were evaluated after chlorin e6 administration at doses of 1-10 mg kg-1 and subsequent irradiation with krypton laser light. Depending on the dose and the time interval between chlorin e6 injection and irradiation, the depth of necrosis in sarcoma 45 varied from 5.0 to 15.0 mm. The cure rate of the animals with sarcoma M-1 varied from 10% to 60%. The antitumor effect was directly proportional to the chlorin e6 dose and light energy exposure and inversely proportional to the time interval between photosensitizer injection and irradiation.</abstract><cop>Lausanne</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier</pub><pmid>8014753</pmid><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1011-1344 |
ispartof | Journal of photochemistry and photobiology. B, Biology, 1994-03, Vol.22 (3), p.211-217 |
issn | 1011-1344 1873-2682 |
language | eng |
recordid | cdi_pubmed_primary_8014753 |
source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Animals Biological and medical sciences Cell Division - drug effects Dose-Response Relationship, Drug Female Lethal Dose 50 Light Medical sciences Mice Mice, Inbred C3H Photochemotherapy Photoradiation therapy and photosensitizing agent Photosensitizing Agents - therapeutic use Photosensitizing Agents - toxicity Porphyrins - pharmacokinetics Porphyrins - therapeutic use Porphyrins - toxicity Radiation-Sensitizing Agents - therapeutic use Radiation-Sensitizing Agents - toxicity Rats Rats, Wistar Sarcoma, Experimental - drug therapy Sarcoma, Experimental - pathology Time Factors Tissue Distribution Treatment with physical agents Treatment. General aspects Tumors |
title | Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T04%3A01%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20grounds%20for%20using%20chlorin%20e6%20in%20the%20photodynamic%20therapy%20of%20malignant%20tumors&rft.jtitle=Journal%20of%20photochemistry%20and%20photobiology.%20B,%20Biology&rft.au=KOSTENICH,%20G.%20A&rft.date=1994-03&rft.volume=22&rft.issue=3&rft.spage=211&rft.epage=217&rft.pages=211-217&rft.issn=1011-1344&rft.eissn=1873-2682&rft.coden=JPPBEG&rft_id=info:doi/&rft_dat=%3Cpubmed_pasca%3E8014753%3C/pubmed_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/8014753&rfr_iscdi=true |