Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan
Serum samples were collected in Hiroshima and Nagasaki, Japan, from 1970 to 1972 for 208 persons who in 1973-1983 developed stomach cancer; for 77 who in 1973-1983 developed lung cancer; and for controls matched for age, sex, city, and season of blood collection. Average serum levels of selenium and...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1994-09, Vol.3 (6), p.465 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | Kabuto, M Imai, H Yonezawa, C Neriishi, K Akiba, S Kato, H Suzuki, T Land, C E Blot, W J |
| description | Serum samples were collected in Hiroshima and Nagasaki, Japan, from 1970 to 1972 for 208 persons who in 1973-1983 developed
stomach cancer; for 77 who in 1973-1983 developed lung cancer; and for controls matched for age, sex, city, and season of
blood collection. Average serum levels of selenium and zinc were slightly (< 5%) but not significantly lower among the cancer
cases than among controls. Smoking-adjusted risks of lung cancer were elevated only among those in the lowest quartiles of
serum selenium [odds ratio (OR) = 1.8] and zinc (OR = 1.3); the trends in risk of this cancer with decreasing serum levels
were neither linear nor significant. Little or no excess risk of stomach cancer was observed among those with lowest levels
of selenium (OR = 1.0) or zinc (OR = 1.2). These exploratory findings add to limited data available from other reports showing
slightly increased risks of lung cancer associated with low blood levels of selenium, but suggest little association with
either lung or stomach cancer across normal selenium or zinc ranges in this Japanese population. |
| format | Article |
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stomach cancer; for 77 who in 1973-1983 developed lung cancer; and for controls matched for age, sex, city, and season of
blood collection. Average serum levels of selenium and zinc were slightly (< 5%) but not significantly lower among the cancer
cases than among controls. Smoking-adjusted risks of lung cancer were elevated only among those in the lowest quartiles of
serum selenium [odds ratio (OR) = 1.8] and zinc (OR = 1.3); the trends in risk of this cancer with decreasing serum levels
were neither linear nor significant. Little or no excess risk of stomach cancer was observed among those with lowest levels
of selenium (OR = 1.0) or zinc (OR = 1.2). These exploratory findings add to limited data available from other reports showing
slightly increased risks of lung cancer associated with low blood levels of selenium, but suggest little association with
either lung or stomach cancer across normal selenium or zinc ranges in this Japanese population.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 8000296</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Case-Control Studies ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Japan - epidemiology ; Lung Neoplasms - blood ; Lung Neoplasms - epidemiology ; Male ; Middle Aged ; Nuclear Warfare ; Radiation Effects ; Registries ; Risk Factors ; Seasons ; Selenium - blood ; Smoking - blood ; Smoking - epidemiology ; Stomach Neoplasms - blood ; Stomach Neoplasms - epidemiology ; Zinc - blood</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 1994-09, Vol.3 (6), p.465</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8000296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kabuto, M</creatorcontrib><creatorcontrib>Imai, H</creatorcontrib><creatorcontrib>Yonezawa, C</creatorcontrib><creatorcontrib>Neriishi, K</creatorcontrib><creatorcontrib>Akiba, S</creatorcontrib><creatorcontrib>Kato, H</creatorcontrib><creatorcontrib>Suzuki, T</creatorcontrib><creatorcontrib>Land, C E</creatorcontrib><creatorcontrib>Blot, W J</creatorcontrib><title>Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Serum samples were collected in Hiroshima and Nagasaki, Japan, from 1970 to 1972 for 208 persons who in 1973-1983 developed
stomach cancer; for 77 who in 1973-1983 developed lung cancer; and for controls matched for age, sex, city, and season of
blood collection. Average serum levels of selenium and zinc were slightly (< 5%) but not significantly lower among the cancer
cases than among controls. Smoking-adjusted risks of lung cancer were elevated only among those in the lowest quartiles of
serum selenium [odds ratio (OR) = 1.8] and zinc (OR = 1.3); the trends in risk of this cancer with decreasing serum levels
were neither linear nor significant. Little or no excess risk of stomach cancer was observed among those with lowest levels
of selenium (OR = 1.0) or zinc (OR = 1.2). These exploratory findings add to limited data available from other reports showing
slightly increased risks of lung cancer associated with low blood levels of selenium, but suggest little association with
either lung or stomach cancer across normal selenium or zinc ranges in this Japanese population.</description><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nuclear Warfare</subject><subject>Radiation Effects</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Seasons</subject><subject>Selenium - blood</subject><subject>Smoking - blood</subject><subject>Smoking - epidemiology</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - epidemiology</subject><subject>Zinc - blood</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj01LxDAQhoMo67r6E4ScvBXSpkmaoyx-rCzoQc9lmky20Ta7Jq2iv95i9zLzvDwwzHtClrngVaaUEKcTMyEyraU4JxcpvTPGlBZiQRbVhIWWS2JfIloPu7BPgzc0YRz7aXYY_AQQLP31wdAOv7BL_zmNTcLPEcNAo08fdO9oN4bd7IZ9D6alBoLBSH2gT3CAcEnOHHQJr457Rd7u717Xj9n2-WGzvt1mbcHVkPEyVzZ3ZdmA1rmU3FgrpAHrHHMMjETWuEIIx_VUktkSClVpbo1TAJW0fEWu57uHsenR1ofoe4g_9bHt5G9m3_pd--0j1vOjERNCNG3Na1mXUvA_GGhhIQ</recordid><startdate>19940901</startdate><enddate>19940901</enddate><creator>Kabuto, M</creator><creator>Imai, H</creator><creator>Yonezawa, C</creator><creator>Neriishi, K</creator><creator>Akiba, S</creator><creator>Kato, H</creator><creator>Suzuki, T</creator><creator>Land, C E</creator><creator>Blot, W J</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19940901</creationdate><title>Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan</title><author>Kabuto, M ; Imai, H ; Yonezawa, C ; Neriishi, K ; Akiba, S ; Kato, H ; Suzuki, T ; Land, C E ; Blot, W J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-3417d1f44ba991663cdd56cadff0f0ac6e0bf255f391530d4a27893dcf7aa86d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nuclear Warfare</topic><topic>Radiation Effects</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Seasons</topic><topic>Selenium - blood</topic><topic>Smoking - blood</topic><topic>Smoking - epidemiology</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - epidemiology</topic><topic>Zinc - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabuto, M</creatorcontrib><creatorcontrib>Imai, H</creatorcontrib><creatorcontrib>Yonezawa, C</creatorcontrib><creatorcontrib>Neriishi, K</creatorcontrib><creatorcontrib>Akiba, S</creatorcontrib><creatorcontrib>Kato, H</creatorcontrib><creatorcontrib>Suzuki, T</creatorcontrib><creatorcontrib>Land, C E</creatorcontrib><creatorcontrib>Blot, W J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabuto, M</au><au>Imai, H</au><au>Yonezawa, C</au><au>Neriishi, K</au><au>Akiba, S</au><au>Kato, H</au><au>Suzuki, T</au><au>Land, C E</au><au>Blot, W J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>1994-09-01</date><risdate>1994</risdate><volume>3</volume><issue>6</issue><spage>465</spage><pages>465-</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Serum samples were collected in Hiroshima and Nagasaki, Japan, from 1970 to 1972 for 208 persons who in 1973-1983 developed
stomach cancer; for 77 who in 1973-1983 developed lung cancer; and for controls matched for age, sex, city, and season of
blood collection. Average serum levels of selenium and zinc were slightly (< 5%) but not significantly lower among the cancer
cases than among controls. Smoking-adjusted risks of lung cancer were elevated only among those in the lowest quartiles of
serum selenium [odds ratio (OR) = 1.8] and zinc (OR = 1.3); the trends in risk of this cancer with decreasing serum levels
were neither linear nor significant. Little or no excess risk of stomach cancer was observed among those with lowest levels
of selenium (OR = 1.0) or zinc (OR = 1.2). These exploratory findings add to limited data available from other reports showing
slightly increased risks of lung cancer associated with low blood levels of selenium, but suggest little association with
either lung or stomach cancer across normal selenium or zinc ranges in this Japanese population.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>8000296</pmid></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 1994-09, Vol.3 (6), p.465 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Case-Control Studies Cohort Studies Female Follow-Up Studies Humans Japan - epidemiology Lung Neoplasms - blood Lung Neoplasms - epidemiology Male Middle Aged Nuclear Warfare Radiation Effects Registries Risk Factors Seasons Selenium - blood Smoking - blood Smoking - epidemiology Stomach Neoplasms - blood Stomach Neoplasms - epidemiology Zinc - blood |
| title | Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan |
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