Measurement of Interleukin-6 Production by Monocytes for in Vitro Safety Testing of Hemoglobin Solutions
Induction of interleukin-6 (IL-6) production by isolated human mononuclear blood cells was taken as in vitro model for the induction of inflammatory reactions. The model was very sensitive to bacterial endotoxin (detection limit < 10pg/ml). Hemoglobin (Hb) solutions, prepared under non-sterile co...
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Veröffentlicht in: | Artificial cells, blood substitutes, and immobilization biotechnology blood substitutes, and immobilization biotechnology, 1994, Vol.22 (3), p.835-840 |
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