Measurement of Interleukin-6 Production by Monocytes for in Vitro Safety Testing of Hemoglobin Solutions

Induction of interleukin-6 (IL-6) production by isolated human mononuclear blood cells was taken as in vitro model for the induction of inflammatory reactions. The model was very sensitive to bacterial endotoxin (detection limit < 10pg/ml). Hemoglobin (Hb) solutions, prepared under non-sterile co...

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Veröffentlicht in:Artificial cells, blood substitutes, and immobilization biotechnology blood substitutes, and immobilization biotechnology, 1994, Vol.22 (3), p.835-840
Hauptverfasser: Bleeker, W. K., De Groot, E. M., Den Boer, P. J., Biessels, P. T. M., Aarden, L. A., Bakker, J. C.
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Sprache:eng
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