Predisposition to Renal Carcinoma in the Eker Rat is Determined by Germ-Line Mutation of the Tuberous Sclerosis 2 (TSC2) Gene

Genetic predisposition to neoplasia often involves tumor suppressor genes. One such model of hereditary renal carcinoma was described in the rat by Eker. These tumors share morphologic similarities with human renal cancer. Linkage analysis localized the inherited mutation to rat chromosome band 10q1...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-11, Vol.91 (24), p.11413-11416
Hauptverfasser:	Yeung, R S, Xiao, G H, Jin, F, Lee, W C, Testa, J R, Knudson, A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cancer Carcinoma - genetics Chromosomes, Human, Pair 16 Complementary DNA DNA Primers - chemistry Gene Expression Gene Rearrangement Genes Genes, Tumor Suppressor Genetic Linkage Genetic loci Genetic mutation Genetics Genomics Heredity Humans Kidney Neoplasms - genetics Kidneys Molecular Sequence Data Mutation Rats Rats, Mutant Strains Repressor Proteins - genetics RNA, Messenger - genetics Rodents Tissue Distribution Tuberous sclerosis Tuberous Sclerosis - genetics Tuberous Sclerosis Complex 2 Protein Tumor cell line Tumor suppressor genes Tumor Suppressor Proteins Tumors
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