Mutagenicity of o-anisidine to the bladder of lacI– transgenic B6C3F1 mice: absence of 14C or 32P bladder DNA adduction

Earlier studies have established that the rodent bladder carcinogen o-anisidine (OA) gives negative results hi all of the standard rodent genetic toxicity assays. In the present study, a single oral administration of the maximum tolerated dose level (750 mg/kg) of OA to B6C3F1 mice yielded negative...

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Veröffentlicht in:	Carcinogenesis (New York) 1994-10, Vol.15 (10), p.2291-2296
Hauptverfasser:	Ashby, J., Short, J.M., Jones, N.J., Lefevre, P.A., Provost, G.S., Rogers, B J., Martin, E.A., Parry, J.M., Burnette, K., GIickman, B.W., Tinwell, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - metabolism Aniline Compounds - toxicity Animals Biological and medical sciences Carbon Radioisotopes Carcinogens - metabolism Carcinogens - toxicity Chemical mutagenesis DNA - drug effects DNA - metabolism DNA Adducts - biosynthesis DNA Adducts - metabolism Dose-Response Relationship, Drug Female Liver - drug effects Liver - metabolism Medical sciences Mice Mice, Transgenic Mutagenicity Tests Mutation Phosphorus Radioisotopes Toxicology Urinary Bladder - drug effects Urinary Bladder - metabolism
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