Design and testing of novel cytotoxic polyamine analogues

We designed three polyamine analogues, 1,14-diamino-N5-methyl-5,10- diazatetradecane (5me-4-4-4), 1,14-diamino-N5,N5-dimethyl-5,10-diazatetradecane (Q-Amm-4-4-4), and 1,14-bis-(ethylamino)-N5,N5-dimethyl-5,10-diazatetradecane (BE-Q-Amm-4-4-4), on the basis of computer modeling and physical-chemical...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-12, Vol.54 (23), p.6210-6214
Hauptverfasser:	BASU, H. S, MARTON, L. J, PELLARIN, M, DEEN, D. F, MCMANIS, J. S, LIU, C. Z, BERGERON, R. J, FEUERSTEIN, B. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Biogenic Polyamines - analysis Biological and medical sciences Brain Neoplasms - pathology Cell Survival - drug effects Drug Design General aspects Humans Medical sciences Pharmacology. Drug treatments Polyamines - pharmacology Solubility Structure-Activity Relationship Tumor Cells, Cultured - drug effects
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