Cystic fibrosis-related diabetes is associated with HLA DQB1 alleles encoding Asp-57- molecules

The incidence of insulin-dependent diabetes in individuals with cystic fibrosis is nearly 100 times greater than in the general population. In the latter group, strong associations with specific HLA DQA1 and DQB1 alleles have been observed. To determine if a similar distribution of alleles occurs in...

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Veröffentlicht in:	Journal of clinical immunology 1994-11, Vol.14 (6), p.353-358
Hauptverfasser:	CARRINGTON, M, KRUEGER, L. J, HOLSCLAW, D. S, IANNUZZI, M. C, DEAN, M, MANN, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Antigens Base Sequence Biological and medical sciences Child Cystic Fibrosis - complications Cystic Fibrosis - genetics Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Histocompatibility antigens (hla, h-2 and other systems) HLA-DQ alpha-Chains HLA-DQ Antigens - genetics HLA-DQ beta-Chains Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Molecular immunology Molecular Sequence Data Mutation - genetics Other diseases. Semiology
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