Use of biological markers in risk assessment
Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, te...
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| Veröffentlicht in: | Risk analysis 1994-10, Vol.14 (5), p.807 |
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| container_title | Risk analysis |
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| creator | McMillan, A Whittemore, A S Silvers, A DiCiccio, Y |
| description | Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy. |
| doi_str_mv | 10.1111/j.1539-6924.1994.tb00292.x |
| format | Article |
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This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy.</description><identifier>ISSN: 0272-4332</identifier><identifier>DOI: 10.1111/j.1539-6924.1994.tb00292.x</identifier><identifier>PMID: 7800865</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Biological Assay - methods ; Biomarkers - analysis ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - chemically induced ; Carcinoma, Squamous Cell - pathology ; Formaldehyde - toxicity ; Humans ; Mice ; Mice, Inbred Strains ; Nose Neoplasms - chemically induced ; Nose Neoplasms - pathology ; Predictive Value of Tests ; Rats ; Rats, Inbred F344 ; Risk ; Risk Factors</subject><ispartof>Risk analysis, 1994-10, Vol.14 (5), p.807</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7800865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McMillan, A</creatorcontrib><creatorcontrib>Whittemore, A S</creatorcontrib><creatorcontrib>Silvers, A</creatorcontrib><creatorcontrib>DiCiccio, Y</creatorcontrib><title>Use of biological markers in risk assessment</title><title>Risk analysis</title><addtitle>Risk Anal</addtitle><description>Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy.</description><subject>Animals</subject><subject>Biological Assay - methods</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - chemically induced</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Formaldehyde - toxicity</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Nose Neoplasms - chemically induced</subject><subject>Nose Neoplasms - pathology</subject><subject>Predictive Value of Tests</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Risk</subject><subject>Risk Factors</subject><issn>0272-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotjstKAzEUQLNQaq1-ghBcm_Hm5jFzl1J8QcGNXZdkkkjamc4wGUH_3oI9m7M7HMbuJVTyxOO-kkaRsIS6kkS6mj0AElY_F2wJWKPQSuEVuy5lDyABTL1gi7oBaKxZsodtiXxI3OehG75y6zreu-kQp8LzkU-5HLgrJZbSx-N8wy6T60q8PXvFti_Pn-s3sfl4fV8_bcSIYGdBLTWNCXVj0VokXSefNAYdWpfA2jaRciY4isqglyQ9BJWSNeBaQxKNWrG7_-747fsYduOUT1O_u_O1-gPdtUPn</recordid><startdate>19941001</startdate><enddate>19941001</enddate><creator>McMillan, A</creator><creator>Whittemore, A S</creator><creator>Silvers, A</creator><creator>DiCiccio, Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19941001</creationdate><title>Use of biological markers in risk assessment</title><author>McMillan, A ; Whittemore, A S ; Silvers, A ; DiCiccio, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-9c9885d7862662947fbf42d4dcaf066cf93a5da9e352b191b0d3ff650ac591253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological Assay - methods</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - chemically induced</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Formaldehyde - toxicity</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Nose Neoplasms - chemically induced</topic><topic>Nose Neoplasms - pathology</topic><topic>Predictive Value of Tests</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Risk</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McMillan, A</creatorcontrib><creatorcontrib>Whittemore, A S</creatorcontrib><creatorcontrib>Silvers, A</creatorcontrib><creatorcontrib>DiCiccio, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Risk analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McMillan, A</au><au>Whittemore, A S</au><au>Silvers, A</au><au>DiCiccio, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of biological markers in risk assessment</atitle><jtitle>Risk analysis</jtitle><addtitle>Risk Anal</addtitle><date>1994-10-01</date><risdate>1994</risdate><volume>14</volume><issue>5</issue><spage>807</spage><pages>807-</pages><issn>0272-4332</issn><abstract>Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy.</abstract><cop>United States</cop><pmid>7800865</pmid><doi>10.1111/j.1539-6924.1994.tb00292.x</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-4332 |
| ispartof | Risk analysis, 1994-10, Vol.14 (5), p.807 |
| issn | 0272-4332 |
| language | eng |
| recordid | cdi_pubmed_primary_7800865 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological Assay - methods Biomarkers - analysis Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - pathology Formaldehyde - toxicity Humans Mice Mice, Inbred Strains Nose Neoplasms - chemically induced Nose Neoplasms - pathology Predictive Value of Tests Rats Rats, Inbred F344 Risk Risk Factors |
| title | Use of biological markers in risk assessment |
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