Multisite Interactions Between Pb2+ and Protein Kinase C and Its Role in Norepinephrine Release from Bovine Adrenal Chromaffin Cells

: We investigated the interaction between Pb2+ and protein kinase C (PKC) in the Pb2+‐induced release of norepinephrine (NE) from permeabilized adrenal chromaffin cells. Our analysis of endogenous PKC activity in permeabilized cells suggests that Pb2+ interacts with the adrenal enzyme at multiple si...

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Veröffentlicht in:	Journal of neurochemistry 1995-06, Vol.64 (6), p.2667-2673
Hauptverfasser:	Tomsig, Jose L., Suszkiw, Janusz B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - cytology Adrenal Glands - metabolism Animals Biological and medical sciences Cattle Cell Membrane Permeability - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Chromaffin cells Chromaffin System - cytology Chromaffin System - metabolism Exocytosis Lead Lead - physiology Medical sciences Metals and various inorganic compounds Norepinephrine Norepinephrine - metabolism Protein kinase C Protein Kinase C - physiology Tetradecanoylphorbol Acetate - pharmacology Toxicology Type C Phospholipases - pharmacology
Online-Zugang:	Volltext
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