Suppression of Heat-Induced hsp70 Expression by the 70-kDa Subunit of the Human Ku Autoantigen

Expression of the 70-kDa polypeptide of human Ku autoantigen in rat cells is shown to suppress specifically the induction of hsp70 upon heat shock. Thermal induction of other heat shock proteins is not significantly affected, nor is the state of phosphorylation or the DNA-binding ability of the heat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-05, Vol.92 (10), p.4512-4516
Hauptverfasser:	Li, Gloria C., Yang, Shao-Hua, Kim, Dooha, Nussenzweig, Andre, Ouyang, Honghai, Wei, June, Burgman, Paul, Li, Ligeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear Autoantigens Autoantigens - metabolism Base Sequence Binding Sites Biochemistry Blotting, Western Cell Line Cell lines DNA DNA Helicases DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - metabolism Fibroblasts - cytology Fibroblasts - metabolism Gels Gene Expression Heat Heat shock proteins Heat Shock Transcription Factors HeLa cells HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - biosynthesis Humans Kinetics Ku Autoantigen Macromolecular Substances Messenger RNA Molecular Sequence Data Nuclear Proteins - biosynthesis Nuclear Proteins - metabolism Oligodeoxyribonucleotides Phosphorylation Proteins Rats Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Shock heating Transcription Factors - metabolism Transfection
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